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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Cyclin E和p16免疫组化染色有助于上皮样滋养叶细胞肿瘤的诊断和鉴别诊断显示文摘 | Mao T L Seidman J D Kurman R J 黄文斌(摘译) | 2006 | 临床与实验病理学杂志2006，22，6： | 12 |
| 3 | Microscopic colitis:A large retrospective analysis from a health maintenance organization experience显示文摘AIM:To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis (MC) in Southern California and to determine the association of MC with inflammatory bowel disease (IBD) and colorectal cancer.METHODS: All patients diagnosed with MC by colonic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients' medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnicity, and medications were analyzed. An age-and sexmatched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis (LC), collagenous colitis (CC) and the control group.RESULTS: A total of 547 cases of MC were identif ied,376 patients with LC and 171 patients with CC. The female/male ratio was 3:1 in CC and 2.7:1 in LC patients. Celiac disease (P<0.001), irritable bowel syndrome (IBS) (P<0.001), and thyroid diseases (P<0.001) were found to have a higher occurrence in MC compared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group.CONCLUSION: This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Furthermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study. | Kevin T Kao Benito A Pedraza Amy C McClune David A Rios Yi-Qiong Mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas | 2009 | World Journal of Gastroenterology2009，15，25： | 5 |
| 4 | Establishment and characterization of two new human embryonic stem cell lines,SYSU-1 and SYSU-2显示文摘背景人的胚胎的干细胞能在 vitro 无止境地宣传并且能区分进所有三胚胎的细菌层的衍生物。主要在他们的潜力包围人的胚胎的干细胞谎言生产的兴奋专业化能被用于的房间移植治疗。然而,进一步的调查与改变基因背景要求另外的房间线。因此,导出并且建立更多的人的胚胎的干细胞线的努力是高度,从施主的 warranted.Methods 剩余胚胎(胚囊) 被用来由 immunosurgery 孤立内部房间团。所有房间在照耀的鼠科的胚胎的成纤维细胞上连续地是有教养的喂层和多半人的胚胎的干细胞殖民地被房间表面标记染色, karyotyping 和 teratoma formation.Results 随后描绘二根人的胚胎的干细胞线(SYSU-1 和 SYSU-2 ) 从剩余胚胎被建立。二根线表示包括碱的磷酸酶, SSEA- 4, Tra-1-60, Oct-4, Nanog 和 Rex-1.They 的标记在延长段落以后与正常 karyotype 处于无差别的状态仍然是的几 pluripotency 并且能在 vivo.Conclusion 在 vitro 和 teratoma 形成胚胎植物或动物身体二根新人的胚胎的干细胞线从剩余胚胎被建立了。他们能被用来理解 selfrenewal 和区分的机制并且为再生药提供更多的选择。 | HUANG Guo LI Wei-qiang CHEN Rui CHEN Zhen-guang ZHANG Xiu-ming MAO Fu-xiang HUANG Shao-liang LI Shu-nong Bruce T Lahn Andy Peng Xiang | 2007 | Chinese Medical Journal2007，，7： | 3 |
| 5 | ZSM-5 zeolite with enhanced acidic properties显示文摘 | Le Van Mao R Le T S Fairbain M Muntasar A Xiao S Denes G | | 0，，： | 2 |
| 6 | Imbalance production between interleukin-1b (IL-1b) and IL-1 receptor antagonist (IL-1ra) in bronchial asthma显示文摘 | Mao XQ Kawai M Yamashita T | 2000 | Biochem Biophys Res Commun2000，276，2： | 1 |
| 7 | Influence of the addition of CeO2 on the microstructure and the magnetic properties of yttrium iron garnet ceramic 显示文摘 | Mao T C Chen J C | 2006 | J Magn Magn Mater2006，302，： | 1 |
| 8 | Models of capital budgeting,E-V versus E-S显示文摘 | Mao J C T | 1970 | Journal of Financial and Quantitative Analysis1970，5，： | 1 |
| 9 | Antioxidative activity of natural isorhapontigenin显示文摘 | Qing L W Mao L Geng T L | 2001 | Jpn J Pharmacol2001，87，： | 1 |
| 10 | Synthesis and Characterization of Novel Fluorescent BOPIM Dyes with Large Stokes Shift 显示文摘 | MAO M F XIAO S Z YI T | 2011 | J Fluorine Chem2011，132，9： | 1 |
| 11 | Charac- terization of fracture behavior in small punch test by combined recrystallization etch method and rigid plastic analysis显示文摘 | MAO X SHOJI T TAKAHASHI H | 1987 | Journal of Testing and Evaluation1987，15，1： | 1 |
| 12 | Fluorescent carbon nanoparticles derived from candle soot 显示文摘 | Liu H Ye T Mao C | 2007 | Angew Chem Int Ed Engl2007，46，34： | 1 |
| 13 | Fluxes of Wa- ter through Aquaporin 9 Weaken Membrane-Cytoskeleton An- chorage and Promote Formation of Membrane Protrusions显示文摘 | Karlsson T Bolshakova A Magalhaes MAO | 2013 | PloS one2013，8，59： | 1 |
| 14 | Non-virus-mediated transfer of siRNAsagainst Runx2 and Smad4 inhibit heterolopic ossification in rats显示文摘 | Xue T Mao Z Lin L | 2010 | Gene Ther2010，17，3： | 1 |
| 15 | Experimental validation of a magnetorheological energy absorber design analysis 显示文摘 | MAO M HU Wei YONG T C WERELEY N M BROWNE A L ULICNY J | 2013 | J Intell Mater Syst Struct2013，25，3： | 1 |
| 16 | Mechanical properties of polyurethane foams prepared from liquefied corn stover with PAPI 显示文摘 | WANG T P ZHANG L H MAO Z H etal | 2008 | Bioresouree Technology2008，99，： | 1 |
| 17 | On path selection and rate allocation for video in wireless mesh networks显示文摘 | Kompella S Mao S Hou Y T | 2009 | IEEE/ACM Transactions on Networking2009，17，1： | 1 |
| 18 | ZSM-5 zeolite with enhanced acidic properties 显示文摘 | Le Van Mao R Le T S Fairbairn M | 1999 | Applied Catalysis A: General1999，185，： | 1 |
| 19 | Equation of state and shear strength at multimegabar pressure:magnesium oxide to 227 GPa 显示文摘 | Duffy T S Hemley R J Mao H K | 1995 | Phys Rev Lett1995，74，： | 1 |
| 20 | Key to mangrove pollen and spores of southern China:an aid to palyno- logical interpretation of Quaternary deposits in the South China Sea显示文摘 | Mao Limi Batten D J Fujiki T | 2012 | Review of Palaeobotany and Pal- ynology2012，17，： | 1 |
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