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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice显示文摘AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in mice.METHODS: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation. | Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas Marek W Radomski Enrique Quintero | 2006 | World Journal of Gastroenterology2006，12，40： | 9 |
| 3 | Quantitative assessment of mRNA TGF - beta 1 in liver tissue in connection with serum mean daily level of TGF - 1 in chronc hepatitis B patient 显示文摘 | MAREK B KAJDANIUK D MAZUREK U | 2005 | Pol Arch Med Wewn2005，114，2： | 1 |
| 4 | Adiponectin, leptin, resistin and insulin blood concentrations in patients with ischaemic cerebral stroke显示文摘 | Bienek R Marek B Kajdaniuk D | 2012 | Endokrynol Pol2012，63，5： | 1 |
| 5 | A model of material flow during friction stir welding显示文摘 | Carter H Stanislaw D Marek B | 2008 | Materials Charac- terization2008，59，： | 1 |
| 6 | Biomarkers for Parkinson's disease:tools to assess Parkinson's disease onset and progression显示文摘 | Marek K Jennings D Tamagnan G | 2008 | Ann Neurol2008，64，2： | 1 |
| 7 | An autosomal recessive form of monilethrix is caused by mutations in DSG4: clinical overlap with localized autosomal recessive hypotrichosis 显示文摘 | Zlotogorski A Marek D Horev L | 2006 | J Invest Dermatol2006，126，6： | 1 |
| 8 | Decomposition of 2, 4-dichlorophenoxyacetie acid by ozonation, ionizing radiation as well as ozonation combined with ionizing radiation显示文摘 | Przemyslaw D Marek T Robert Z Sonja S Peter G | 2004 | Radiation Physics and Chemistry2004，69，： | 1 |
| 9 | Chemical Interaction in Blends of Polyamide and Butyl Rubbers显示文摘 | Van Dyke J D(Jack) Gnatowski Marek Koutsandreas Andy | | 0，，04： | 1 |
| 10 | Characterization of forward -directivity ground motions in the near-fault region显示文摘 | Jonathan D B Adrian Rodriguez Marek | 2004 | Soil Dynamics and Earthquake Engineering2004，24，： | 1 |
| 11 | Vascular endothelial growth factor(VEGF)-part 1:in physiology and pathophysiology显示文摘 | Kajdaniuk D Marek B Foltyn W | 2011 | Endokrynol Pol2011，62，5： | 1 |
| 12 | Concentration of radioactive aqueous wastes: Electro migration through ion-exchange membrane显示文摘 | Waiters W R Weiser D W Marek L J | 1955 | Industrial and Engineering Chemistry1955，47，1： | 1 |
| 13 | Introduction of blastocyst culture and transfer for all patients in in - vitro fertilization program 显示文摘 | Marek D Langley M Gardner DK | 1999 | Fertil Stefil1999，72，： | 1 |
| 14 | Algebraic Schwarz methods for the numerical solution of Markov chains显示文摘 | Marek I Szyld D B | 2004 | Linear Algebra Appl2004，386，： | 1 |
| 15 | Evaluation of the ruggedness of power DMOS transistor from electro-thermal simulation of UIS behaviour显示文摘 | DONOVAL D VRBICKY A MAREK J | 2008 | SSE2008，52，6： | 1 |
| 16 | Expression profiles of Toll-like receptors 1, 2 and 5 in selected organs of commercial and indigenous chickens显示文摘 | Anna S?awińska Mariasilvia D’Andrea Fabio Pilla Marek Bednarczyk Maria Siwek | 2013 | Journal of Applied Genetics2013，，4： | 1 |
| 17 | An autosomal re-cessive form of monilethrix is caused by mutations inDSG4 : clinical overlap with localized autosomal recessivehypotrichosis显示文摘 | Zlotogorski A Marek D Horev L et at | 2006 | The Journal of Investigative Dermatolo-gy2006，126，20： | 1 |
| 18 | Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients 显示文摘 | MARIA C MATEUSZ K MAREK D | 2006 | Pharmacological Reports2006，58，6： | 1 |
| 19 | Expression and genome organization of resistance gene analogs in soy bean 显示文摘 | Graham M A Marek L F Lohnes D | 2000 | Genome2000，43，： | 1 |
| 20 | Influence of structural abnormalities on dispersion of cardiac repolarization in hypertrophy cardiomyopathy and hypertensive left ventricular hypertrophy显示文摘 | Alicja D K Andrzfj L B Marek S | 2000 | Cardiol Pol2000，53，： | 1 |
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