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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Shoot and root traits in drought tolerant maize(Zea mays L.) hybrids显示文摘This study aimed to investigate the differences in shoot and root traits, and water use and water use efficiency(WUE) in drought tolerant(DT) maize(Zea mays L.) hybrids under full and deficit irrigated conditions. A two-year greenhouse study was conducted with four hybrids(one conventional hybrid, 33D53AM, two commercial DT hybrids, P1151 AM, N75H, and an experimental hybrid, Exp HB) grown under two water regimes(I_(100) and I_(50), referring to 100 and 50% of evapotranspiration requirements). Under water stress, the hybids P1151 AM, N75, and Exp HB showed more drought tolerance and had either greater shoot dry weight or less dry weight reduction than the conventional hybrid(33 D53 AM). However, these three hybrids responded to water stress using different mechanisms. Compared with the conventional hybrid, the two commercial DT hybrids(P1151 AM and N75H) had a smaller leaf area, shoot dry weight, and root system per plant. As a result, these hybrids used less water but had a higher WUE compared with the conventional hybrid. In contrast, the experimental hybrid(ExpHB) produced more shoot biomass by silking stage at both irrigation levels than all other hybrids, but it had relatively lower WUE. The hybrids demonstrated different drought response mechanisms that may require different irrigation management strategies. More investigation and validation are needed under field conditions and in different soil types. | ZHAO Jin XUE Qing-wu Kirk E Jessup HOU Xiao-bo HAO Bao-zhen Thomas H Marek XU Wen-wei Steven R Evett Susan A O'Shaughnessy David K Brauer | 2018 | Journal of Integrative Agriculture2018，17，5： | 3 |
| 4 | Green fluorescent protein as a vital marker for non-destructive detection of transformation events in transgenic plants显示文摘 | Marek H Slavom R Vladislav C | 2006 | Plant Cell Tissue and Organ Culture2006，86，3： | 1 |
| 5 | A new integrated genetic linkage map of the soybean显示文摘 | Song Q J Marek L F Shoemaker R C | 2004 | Theoretial and Applied Genetics2004，109，： | 1 |
| 6 | A new integrated ge-netic linkage map of the soybean显示文摘 | Song Q J Marek L F Shoemaker R C | 2004 | Theoretical and Applied Ge-netics2004，109，： | 1 |
| 7 | Ultrasound sonoelastography in the evaluation of thyroiditis and au- toimmune thyroid DISEASE 显示文摘 | MAREK R KRZYSZTOF S SYLWIA S | 2014 | Endokrynologia Polska2014，65，6： | 1 |
| 8 | β-CIT SPECT imaging assessment of the rate of Parkinson's disease progression显示文摘 | Marek K Innis R van Dyck C | 2001 | Neurology2001，57，： | 1 |
| 9 | Silica recovery from waste obtained in hydrofluoric acid and aluminum fluoride produc- tion from fluosilicic acid显示文摘 | Andrzej K Bozena R Marek M | 1996 | Journal of Hazardous Materials1996，48，： | 1 |
| 10 | Adiponectin, leptin, resistin and insulin blood concentrations in patients with ischaemic cerebral stroke显示文摘 | Bienek R Marek B Kajdaniuk D | 2012 | Endokrynol Pol2012，63，5： | 1 |
| 11 | gene analogs are conserved and clusteredin soybean 显示文摘 | KANAZIN V MAREK L F SHOEMAKER R | 1996 | Proc Natl Acad Sci USA1996，93，11： | 1 |
| 12 | Silieareeovery from waste obtained in hydrofluoric acid and aluminum fluoride production from fluosilicie acid显示文摘 | Andrzej K Bozena R Marek M | 1996 | Journal of Hazardous Materials1996，48，： | 1 |
| 13 | Ultrasound sonoelastography in the evaluation of thyroiditis and au- toimmune thyroid disease 显示文摘 | MAREK R KRZYSZTOF S SYLWIA S | 2014 | Endokrynologia Polska2014，65，6： | 1 |
| 14 | Subclinical hypothyroidism 显示文摘 | Krysiak R Marek B Okopien B | 2008 | Wiad Lek2008，61，46： | 1 |
| 15 | A new integrated genetic linkage map of the soybean 显示文摘 | Song Q J Marek L F Shoemaker R C | 2004 | Theoretical and App lied Genetics2004，109，1： | 1 |
| 16 | Resistance gene analogs are conserved and clustered in soybean 显示文摘 | Kanazin V Marek L F Shoemaker R C | 1996 | Proceedings of the National Academy of Sciences of the USA1996，93，11： | 1 |
| 17 | Control of nitric oxide nitrous,oxide,and ammonia emissions using microwave plasmas显示文摘 | MAREK A W FRANCIS P M GRIMES R W | 2000 | Journal of Hazardous Materials2000，74，29： | 1 |
| 18 | A new integrated ge- netic linkage map of the soybean显示文摘 | Song Q J Marek L F Shoemaker R C | 2004 | Theoretical and Applied Ge-netics2004，109，： | 1 |
| 19 | The fate of nitrogen functionalities in coal during pyrolysis and combustion显示文摘 | Marek A Wo Jan R P Jacob A M | 1995 | Fuel1995，74，4： | 1 |
| 20 | A new inte- grated genetic linkage map of the soybean 显示文摘 | Song Q J Marek L F Shoemaker R C | 2004 | Theoreti- cal and Applied Genetics2004，109，1： | 1 |
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