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| 1 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 2 | 温度测量系统对ADC的要求显示文摘引言
适用于温度测量的温度传感器有好几种。为具体应用选择适当的温度传感器取决于待测温度范围以及所需要的精度。系统精度取决于温度传感器的精度以及用于将传感器输出数字化的模数转换器(ADC)的性能。多数情况下,传感器的信号幅度相当小,需要一种高分辨率的ADC。∑-△ADC分辨率高,通常包含温度测量系统所需的内置电路,如激励电流源。本文讨论不同类型的温度传感器(热电偶、电阻式温度检测器(RTD)、热敏电阻以及热敏二极管)以及连接传感器和ADC所需要的电路,还介绍对ADC的性能要求。 | Mary Mc Carthy Eamonn Dillon | 2006 | 世界电子元器件2006，，8： | 2 |
| 3 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 4 | Twenty-year trends in the prev- alence of down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening显示文摘 | Loane M Marie JK Addor MC | 2013 | European Journal of Human Genetics2013，21，1： | 1 |
| 5 | Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth显示文摘 | Adrie JC Edsmond MC Mary KH | 2002 | PNAS2002，99，5： | 1 |
| 6 | Does regular massage from late pregnancy to birth decrease maternal pain perception during labour and birth?—A feasibility study to investigate a programme of massage, controlled breathing and visualization, from 36 weeks of pregnancy until birth显示文摘 | Mary T. Mc Nabb Linda Kimber Anne Haines Christine McCourt | 2006 | Complementary Therapies in Clinical Practice2006，，3： | 1 |
| 7 | The role of the clinical nurse specialist in an adult congenital heart disease program显示文摘 | Mary MC Maya JD | 1994 | Nurse Clin of North Am1994，29，2： | 1 |
| 8 | Combining genetic markers and stable isotopes to reveal population connectivity and migration patterns in a Neotropical migrant, Wilson's warbler (Wilsonia pusilla)显示文摘 | Sonya MC Jeffrey FK Mari Kimura | 2003 | Mol Ecol2003，12，： | 1 |
| 9 | Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth显示文摘 | Adrie JC Edsmond MC Mary KH | 2002 | PNAS2002，99，5： | 1 |
| 10 | Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm显示文摘 | Mary M Anne MC Ripal G | 2005 | J Vasc Interv Radiol2005，16，7： | 1 |
| 11 | Do phytoestrogens reduce the risk of breast cancer and breast cancer recurrence? What clinicians need to know显示文摘 | LOUIXA SV JAYNE VW MARIE MC | 2008 | Eur J Cancer2008，44，13： | 1 |
| 12 | Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency显示文摘 | Marie S Race V Nassogne MC | 2002 | Am J Hum Genet2002，71，1： | 1 |
| 13 | Candidate mechanisms for capecitabine-related hand-foot syndrome 显示文摘 | Milano G Etienne-Grimaldi MC Mari M | 2008 | Br J Clin Pharmacol2008，66，1： | 1 |
| 14 | The role of clinical nurse specialist in an adult congenital heart diease program 显示文摘 | Mary MC Maya JD | 1994 | Nurse Clin of North Am1994，29，2： | 1 |
| 15 | Development of brief stress management support groups for couples undergoing in vitro fertilization treatment显示文摘 | Mary Ellen MC Michael B Sara EV | 2000 | Fertil Steril2000，7，1： | 1 |
| 16 | Are infants with orofacial clefts at risk for insecure mother-child attachments显示文摘 | Maris CL Endriga MC Speltz ML | 2000 | Cleft Palate Craniofac J2000，37，3： | 1 |
| 17 | The role of the clinical nurse specialist in all adult congenital heart diseaseprogram显示文摘 | Mary MC Maya JD | 1994 | Nurse Clin of North Am1994，29，2： | 1 |
| 18 | Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers显示文摘 | Maris NA de Vos AF Dessing MC | 2005 | Am J Respir Crit Care Med2005，172，7： | 1 |
| 19 | Demonstration of rapid onset vascular endotheliald ysfunction afte rhyperhomo cysteinemia : an effect reversible with vitaminC therapy 显示文摘 | Chambers JC Mc GregorA Jean Marie J | 1999 | Circulation1999，99，9： | 1 |
| 20 | Evidence is good for your health system: policy reform to remedy catastrophic and impoverishing health spending in Mexico显示文摘 | Marie KF Hector AO Oscar MC | 2006 | The Lancet2006，368，9549： | 1 |
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