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| 1 | Review of anticancer mechanisms of isoquercitin显示文摘This review was based on a literature search of PubM ed and Scielo databases using the keywords 'quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer' and combinations of all the words.We collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of isoquercitin.Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom.The subclass of flavonols receives special attention owing to their health benefits.The main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone form.IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and anti-diabetic.The protective effects of IQ in cancer may be due to actions on lipid peroxidation.In addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein signaling.This review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer. | Guilherme di Camillo Orfali Ana Carolina Duarte Vivien Bonadio Natalia Peres Martinez Maria Elisa Melo Branco de Araújo Fernanda Bruschi Marinho Priviero Patricia Oliveira Carvalho Denise Gon?alves Priolli | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 2 | Thermal bridging of graphene nanosheets via covalent molecular junctions: A non-equilibrium Green's functions-density functional tightbinding study显示文摘Despite the uniquely high thermal conductivity of graphene is well known,the exploitation of graphene into thermally conductive nanomaterials and devices is limited by the inefficiency of thermal contacts between the individual nanosheets.A fascinating yet experimentally challenging route to enhance thermal conductance at contacts between graphene nanosheets is through molecular junctions,allowing covalently connecting nanosheets,otherwise interacting only via weak Van der Waals forces.Beside the bare existence of covalent connections,the choice of molecular structures to be used as thermal junctions should be guided by their vibrational properties,in terms of phonon transfer through the molecular junction.In this paper,density functional tight-binding combined with Green's functions formalism was applied for the calculation of thermal conductance and phonon spectra of several different aliphatic and aromatic molecular junctions between graphene nanosheets.Effects of molecular junction length,conformation,and aromaticity were studied in detail and correlated with phonon tunnelling spectra.The theoretical insight provided by this work can guide future experimental studies to select suitable molecular junctions,in order to enhance the thermal transport by suppressing the interfacial thermal resistances.This is attractive for various systems,including graphene nanopapers and graphene polymer nanocomposites,as well as related devices.In a broader view,the possibility to design molecular junctions to control phonon transport currently appears as an efficient way to produce phononic devices and controlling heat management in nanostructures. | Diego Martinez Gutierrez Alessa ndro Di Pierro Alessa ndro Pecchia Leon ardo Medra no San donas Rafael Gutierrez Mar Bernal Bohayra Mortazavi Gianaurelio Cuniberti Guido Saracco Alberto Fina | 2019 | Nano Research2019，12，4： | 2 |
| 3 | Seven novel point mulations in the uroporphyrinogen decarboxylase (UROD) gene in patients with familial porphyria cutanea larda (f-PCT) 显示文摘 | Cappellini MD Martinez di Montemuros F Tavazzi D | 2001 | Hum Murat2001，17，4： | 1 |
| 4 | MAP2, synaptophysin immunostaining in rat brain and behavioral modifications after cerebral postischemie reperfusion显示文摘 | Martinez G Di Giacomo C Carnazza ML | 1997 | Dev Neurosci1997，19，： | 1 |
| 5 | Expression of bone morphogenetic protein-6 and transforming growth factor-β1 in the rat brain after a mild and reversible ischemic damage 显示文摘 | Martinez G Carnazza ML Di Giacomo C | 2001 | Brain Research2001，894，1： | 1 |
| 6 | MAP2, synaptophysin immunostaining in rat brain and behavioral modifications after cerebral postischemie reperfusion 显示文摘 | Martinez G Di GC Carnazza ML | 1997 | Dev Neurosci1997，19，6： | 1 |
| 7 | Expression of Bone Morphogenetic Protein-6 and Transforming Growth Faetor-betal in the Rat Brain After a Mild and Reversible Isehemie Damage显示文摘 | MARTINEZ G CARNAZZA ML DI GIACOMO C | 2001 | Brain Research(S0006--8993)2001，，： | 1 |
| 8 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 9 | MAP2, synaptophysin immunostaining in rat brain and behavioral modifications after cerebral postischemic reperfusion显示文摘 | Martinez G Di Giacomo C Camazza ML | 1997 | Deve Neurosci1997，19，6： | 1 |
| 10 | Evalua- tion of acetabular fractures with two and three dimension- alCT显示文摘 | Martinez CR Di Pasquale TG Helfet DL | 1992 | Radio Graphics1992，12，2： | 1 |
| 11 | Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion显示文摘 | MARTINEZ G DI GIACOMO C SORRENTI V | 2004 | Neurotoxicology2004，25，5： | 1 |
| 12 | Fibroblast growth factor-2 and transforming growth factor-betal immunostaining in rat brain after cerebral postischemic reperfusion显示文摘 | Di Giacomo C Sorrenti V | 2001 | J Neurosci Res2001，63，2： | 1 |
| 13 | Fibroblast growth factor-2 and transforming growth factor-beta1 immunostaining in rat brain after cerebral postischemic reperfusion显示文摘 | Martinez G Di Giacomo C Sorrenti V | 2001 | J Neurosci Res2001，63，2： | 1 |
| 14 | Intact fetal cell isolation from maternal blood:improved isolation using a simple whole blood progenitor cell enrichment approach (RosetteSep)显示文摘 | BISCHOFF FZ MARQUEZ-DO DA MARTINEZ DI | 2003 | Clin Genet2003，63，6： | 1 |
| 15 | Comparison of two analog-based downscaling methods for regional reference evapotranspiration forecasts显示文摘 | Di Tian Christopher J. Martinez | 2012 | Journal of Hydrology2012，，： | 1 |
| 16 | Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer′s disease 显示文摘 | Martinez A Perez DI Gil C | 2013 | Curr Top Med Chem2013，13，15： | 1 |
| 17 | MAP-2,synaptophysin immunostaining in rat brain and behavioral modifications after cerebral postischemic reperfusion显示文摘 | Martinez G Di Giacomo C Carnazza ML | | 0，，： | 1 |
| 18 | Effects of norepinephrine depletion in rats during cerebral post ischemic reperfusion显示文摘 | Martinez G Di Giacomo C Sorrenti V | 2004 | Neurotoxicology2004，25，5： | 1 |
| 19 | Optimization of the Mix-Design System for the Sub-ballast Railroad显示文摘 | Martinez Soto Fernando Di Mino Gaetano | 2017 | Journal of Traffic and Transportation Engineering2017，5，5： | 1 |
| 20 | Fibroblast growth factor-2 and transforming growth factor-betal immtmostaining in rat brain after cerebral postischcmic reperfusion显示文摘 | Martinez G Di Giacomo C Sorrenti V | 2001 | J Neumsci Res2001，63，2： | 1 |
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