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| 1 | Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates显示文摘AIM: To investigate the prevalence of vacuolating cytotoxin (vacA), cytotoxin associated gene A (cagA) and blood adhesion binding antigen (babA2) genotypes of Helicobacter pylori (H pylori) isolates from Cuban dyspeptic patients. METHODS: DNA was extracted from H pylori-positive cultures taken from 130 dyspeptic patients. Genotyping was performed by PCR, using specifi c primers for vacA (s1, s2, m1, m2), cagA and babA2 genes. Endoscopic observations and histological examinations were used to determine patient pathologies. RESULTS: vacA alleles s1 , s2 , m1 and m2 were detected in 96 (73.8%), 34 (26.2%), 75 (57.7%) and 52 isolates (40%), respectively, while the cagA gene was detected in 95 isolates (73.2%). One hundred and seven isolates (82.3%) were babA2-positive. A signif icant correlation was observed between vacAs1m1 and cagA and between vacAs1m1 and babA2 genotypes (P < 0.001 and P < 0.05, respectively) and between babA2 genotype and cagA status (P < 0.05); but, no correlation was observed between vacAs1 and babA2 genotypes. Eighty fi ve (65.4%) and 73 (56.2%) strains were type 1 (vacAs1-cagA-positive) and 'triple- positive' (vacAs1-cagA-babA2-positive), respectively, and their presence was significantly associated with duodenal ulcer (P < 0.01 and P < 0.001, respectively). CONCLUSION: The distribution of the main virulence factors in the Cuban strains in this study resembled that of the Western-type strains, and the more virulent H pylori isolates were signifi cantly associated with duodenal ulcer, ulcer disease being the worst pathology observed in the group studied. | Lino E Torres Karelia Melián Arlenis Moreno Jordis Alonso Carlos A Sabatier Mayrín Hernández Ludisleydis Bermúdez Boris L Rodríguez | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 2 | Cervical cancer diagnosed shortly after pregnancy: prognostic variables and delivery routes 显示文摘 | Sood AK Sorosky JI Mayr N | 2000 | Obstet Gynecol2000，95，61： | 1 |
| 3 | Long-term results of unstable pelvic ring fracture in children显示文摘 | Schwarz N Posch E Mayr J | 1998 | Injury1998，29，6： | 1 |
| 4 | Sleep and Epilepsy显示文摘 | Zeitlhofer J Baumgarther C Mayr N | 1991 | Wien Klin Wochenschr1991，107，7： | 1 |
| 5 | Cervical cancer diag- nosed shortly after pregnancy: prognostic variables and delivery routes 显示文摘 | Sood AK Sorosky JI Mayr N | 2000 | Obstet Gvnecol2000，95，： | 1 |
| 6 | Cervical cancer diagnosed shortly after pregnancy:prognostic variables and delivery routes显示文摘 | SOOD AK SEOROSKY JL MAYR N | 2000 | Obstet Gyneeol2000，95，61： | 1 |
| 7 | A single nucleotide change inthe mouse genome accelerates breast cancer progression显示文摘 | Seitzer N Mayr T Streit S | 2010 | Cancer Res2010，70，2： | 1 |
| 8 | Radio-therapeutic management of cervical carcinoma that complicates pregnancy 显示文摘 | Sood AK Sorosky JI Mayr N | 1997 | Cancer1997，80，6： | 1 |
| 9 | The association between vitamin D receptor expression and prolonged overall survival in breast cancer 显示文摘 | Ditsch N Toth B Mayr D | 2012 | J Histochem Cytochem2012，60，2： | 1 |
| 10 | Cervical cancer diagnosed shortly after pregnancy:prognostic variables and delivery routes显示文摘 | Sood AK Sorosky JI Mayr N | 2000 | Obstet Gynecol2000，95，6： | 1 |
| 11 | Cervical Cancer Diagnosed Shortly After Pegnancy: prognostic variables and delivery routes显示文摘 | Sood AK Sorosky JI Mayr N | 2000 | Obstet Gynecol2000，95，61： | 1 |
| 12 | Cervical cancer diag- nosed shortly after pregnancy:Prognostic variables and de- livery routes 显示文摘 | Sood AK Sorosky JI Mayr N | 2000 | Obstet Gynecol2000，95，61： | 1 |
| 13 | Copeptinand arginine vasopressin concentrations in critically ill patients显示文摘 | Jochberger S Morgenthaler N G Mayr V D | 2006 | Journal of Clinical Endocrinology & Metabolism2006，91，11： | 1 |
| 14 | Cervical cancer diabgosed short- ly after pregnancy : prognostic variables and delivery routes 显示文摘 | Sood AK Sorosky Jl Mayr N | 2000 | Ob- stet Gynecol2000，95，61： | 1 |
| 15 | The 7Beelectron-capture Rate显示文摘 | MAYR M | 1969 | Astrophys J1969，155，： | 1 |
| 16 | Cervical cancer diag-nosed shortly after pregnancy : prognostic variables and de-livery routes显示文摘 | Sood AK Sorosky JI Mayr N | 2000 | Obstet Gynecol2000，95，61： | 1 |
| 17 | Cranial nerve involvement in nasopharyngeal carcinoma: response to radiotherapy and its elinieal impaet显示文摘 | LI J C MAYR N A YUH W T | 2006 | Ann Otol Rhinol Laryngol2006，115，： | 1 |
| 18 | Radiotherapeutic management of cervical carcinoma that complicates pregnancy 显示文摘 | Sood AK Sorosky JI Mayr N | 1997 | Cancer1997，80，： | 1 |
| 19 | Cervical cancer diagnosed shortly after pregnancy: Prognostic variables and delivery routs 显示文摘 | Stood AK Sorosky JI Mayr N | 2000 | Obstet Gynecol2000，95，： | 1 |
| 20 | The role of radiation therapy in the treatment of solitary plasmacytomas 显示文摘 | Mayr N A Wen B-C Hussey DH | 1990 | Radiotherapy and Oncology1990，17，： | 1 |
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