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| 1 | Helicobacter pylori arginase mutant colonizes arginase Ⅱ knockout mice显示文摘AIM: To investigate the role of host and bacterial arginases in the colonization of mice by Helicobacter pylori (H.pylori).METHODS: H.pylori produces a very powerful urease that hydrolyzes urea to carbon dioxide and ammonium,which neutralizes acid.Urease is absolutely essential to H.pylori pathogenesis;therefore,the urea substrate must be in ample supply for urease to work efficiently.The urea substrate is most likely provided by arginase activity,which hydrolyzes L-arginine to L-ornithine and urea.Previous work has demonstrated that H.pylori arginase is surprisingly not required for colonization of wild-type mice.Hence,another in vivo source of the critical urea substrate must exist.We hypothesized that the urea source was provided by host arginase Ⅱ,since this enzyme is expressed in the stomach,and H.pylori has previously been shown to induce the expression of murine gastric arginase Ⅱ.To test this hypothesis,wild-type and arginase (rocF) mutant H.pylori strain SS1 were inoculated into arginase Ⅱ knockout mice.RESULTS: Surprisingly,both the wild-type and rocF mutant bacteria still colonized arginase Ⅱ knockout mice.Moreover,feeding arginase Ⅱ knockout mice the host arginase inhibitor S-(2-boronoethyl)L-cysteine (BEC),while inhibiting > 50% of the host arginase Ⅰ?activity in several tissues,did not block the ability of the rocF mutant H.pylori to colonize.In contrast,BEC poorly inhibited H.pylori arginase activity.CONCLUSION: The in vivo source for the essential urea utilized by H.pylori urease is neither bacterial arginase nor host arginase Ⅱ;instead,either residual host arginase Ⅰ?or agmatinase is probably responsible. | Songhee H Kim Melanie L Langford Jean-Luc Boucher Traci L Testerman David J McGee | 2011 | World Journal of Gastroenterology2011，17，28： | 3 |
| 2 | Glycine max: a potential hostof the peanut web blotch fungus显示文摘 | Smith D H McGee R E | 1981 | Proceedings of theAmerican Peanut Research and Education Society1981，，13： | 1 |
| 3 | Supplemental L-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury显示文摘 | Sato H Zhao ZQ Mcgee DS | 1995 | J Thorac Cardiovasc Surg1995，110，2： | 1 |
| 4 | Identifying mieroRNAs involved in degeneration of the organ of corti during age-related hearing loss 显示文摘 | Zhang Q Liu H McGee J | 2013 | PLoS One2013，8，62： | 1 |
| 5 | Applying local knowledge:the contri- bution of oral history to wetland rehabilitation at kanyapella basin, Australia显示文摘 | Robertson H A McGee T K | 2003 | Journal of Environmental Management2003，69，3： | 1 |
| 6 | Can the concepts of depression and quality of life be integrated using a time perspective显示文摘 | Moor M Hofer S McGee H | | 0，，： | 1 |
| 7 | Identifying microRNAs involvedin degeneration of the organ of corti during age-related hearing loss显示文摘 | Zhang Q Liu H Mcgee J | 2013 | PLoS One2013，8，62： | 1 |
| 8 | Strategic groups: Theory, research and taxonomy 显示文摘 | McGee J Thomas H | 1986 | Strategic Management Journal1986，7，2： | 1 |
| 9 | Use of bioluminese- centbaetefiumphotobacteriumphosphoreum to biohazardous materials inwater 显示文摘 | Thomtdka K W McGee D J Lange J H | 1993 | Bulletin detect potentially of Environmental Contamination and Toxicology1993，51，4： | 1 |
| 10 | Evaluation of triamcinolone acetonide following intravitreal injection in New Zealand white rabbits 显示文摘 | MCGEE D H DEMBINSKA O GRUEBBEL M M | 2005 | Int J Toxicol2005，24，6： | 1 |
| 11 | Use of the bioluminescent bacterium phosphoreum to detect potentially biohazardous materials in water显示文摘 | Thomulk K W McGee D J Lange J H | 1993 | Bull Eviron Contain Toxicol1993，51，4： | 1 |
| 12 | Strategic groups: theory research and taxonom显示文摘 | Mcgee J Thomas H | 1986 | Strategic Management Journal1986，7，： | 1 |
| 13 | Calcareous nannofossil biostratigraphic dating of a ferromanganese crust from Schumann Seamount显示文摘 | Cowen J P DeCarlo E H and McGee D L | 1993 | Marine Geology1993，115，： | 1 |
| 14 | Assessing adheretme to dietary recommendations for hemodialysis patients: the Renal Adherence Attitudes Questionnaire (RAAQ) and the Re- nal Adherence Behaviour Questionnaire (RABQ) 显示文摘 | Rushe H McGee H M | 1998 | J Psychosom Res1998，45，2： | 1 |
| 15 | Neonatal exposure to UV-B radiation leads to a large reduction in Langerhans cell density,but by maturity, there is an enhanced ability of dendritic cells to stimulate T cells 显示文摘 | McGee H Scott D K Woods G M | 2006 | Immunol Cell Biol2006，84，3： | 1 |
| 16 | Use of the biolum inescent bacterium photobacterium phosphoreum to detect potentially bio-hazardous materials in water显示文摘 | Thomulk K W McGee D J Lange J H | 1993 | Bull Environ Contain Toxicol1993，51，4： | 1 |
| 17 | Meehanisisms of Helicobacter Pylori Infection:Bacterial Factors显示文摘 | Mcgee D J Mobley H L | 1999 | Curt Top Microbiol Immunol1999，241，： | 1 |
| 18 | Assessing adherence to dietaryrecommendations for hemodialysis patients:the Renal Atti-tudes Questionnaire (RAAQ) and the Reanal AdherenceBehaviour Questionaire (RABQ) 显示文摘 | Rushe H McGee HM | 1998 | Psychosom Res1998，45，2： | 1 |
| 19 | Guidelines for timing yellow and red intervals at signalized inter- sections显示文摘 | MCGEE H MORIARTY K ECCLES T J | 2012 | Transportation Research Record:Journal the Transportation Research Board2012，，2298： | 1 |
| 20 | Com- prehensive evaluation of driver behavior to establish parameters for timing of yellow change and red clear- ance intervals 显示文摘 | GATES T J MCGEE H MORIARTY K | 2012 | Transportation Research Record Journal of the Transportation Research Board2012，，2298： | 1 |
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