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| 1 | Sphincter of Oddi dysfunction and pancreatitis显示文摘Sphincter of Oddi dysfunction (SOD) is a term used to describe a group of heterogenous pain syndromes caused by abnormalities in sphincter contractility. Biliary and pancreatic SOD are each sub-classified as typeⅠ,Ⅱ or Ⅲ,according to the Milwaukee classification. SOD appears to carry an increased risk of acute pancreatitis as well as rates of post ERCP pancreatitis of over 30%. Various mechanisms have been postulated but the exact role of SOD in the pathophysiology of acute pancreatitis is unknown. There is also an association between SOD and chronic pancreatitis but it is still unclear if this is a cause or effect relationship. Management of SOD is aimed at sphincter ablation,usually by endoscopic sphincterotomy (ES). Patients with typeⅠSOD will benefit from ES in 55%-95% of cases. Sphincter of Oddi manometry is not necessary before ES in typeⅠ SOD. For patients with types Ⅱ and Ⅲ the benefit of ES is lower. These patients should be more thoroughly evaluated before performing ES. Some researchers have found that manometry and ablation of both the biliary and pancreatic sphincters is required to adequately assess and treat SOD. In pancreatic SOD up to 88% of patients will benefit from sphincterotomy. Therefore,there have been calls from some quarters for the current classification system to be scrapped in favour of an overall system encompassing both biliary and pancreatic types. Future work should be aimed at understanding the mechanisms underlying the relationship between SOD and pancreatitis and identifying patient factors that will help predict benefit from endoscopic therapy. | MT McLoughlin RMS Mitchell | 2007 | World Journal of Gastroenterology2007，13，47： | 37 |
| 2 | Endoscopic stenting-Where are we now and where can we go?显示文摘Self expanding metal stents (SEMS) play an important role in the management of malignant obstructing lesions in the gastrointestinal tract. Traditionally,they have been used for palliation in malignant gastric outlet and colonic obstruction and esophageal malignancy. The development of the polyflex stent,which is a removable self expanding plastic stent,allows temporary stent insertion for benign esophageal disease and possibly for patients undergoing neoadjuvant chemotherapy prior to esophagectomy. Potential complications of SEMS insertion include perforation,tumour overgrowth or ingrowth,and stent migration. Newer stents are being developed with the aim of increasing technical and clinical success rates,while reducing complication rates. Other areas of development include biodegradable stents for benign disease and radioactive or drug-eluting stents for malignant disease. It is hoped that,in the future,newer stents will improve our management of these diffi cult conditions and,possibly,provide prognostic as well as symptomatic benefi t in the setting of malignant obstruction. | Mark Terence McLoughlin Michael Francis Byrne | 2008 | World Journal of Gastroenterology2008，14，24： | 11 |
| 3 | Colorectal cancer screening显示文摘Colorectal cancer is a major public health burden worldwide. There is clear-cut evidence that screening will reduce colorectal cancer mortality and the only contentious issue is which screening tool to use. Mos evidence points towards screening with fecal occul blood testing. The immunochemical fecal occult blood tests have a higher sensitivity than the guaiac-based tests. In addition, their automation and haemoglobin quantification allows a threshold for colonoscopy to be selected that can be accommodated within individua health care systems. | Ramona M McLoughlin Colm A O'Morain | 2006 | World Journal of Gastroenterology2006，12，42： | 8 |
| 4 | Cirrhosis complicating Shwachman-Diamond syndrome: A case report显示文摘BACKGROUND The features of Shwachman-Diamond syndrome (SDS) include exocrine pancreatic insufficiency, skeletal abnormalities and bone marrow dysfunction;an often overlooked feature is hepatic involvement. CASE SUMMARY We report a child who initially presented with failure to thrive and mildly elevated transaminase levels and was determined to have pancreatic insufficiency due to SDS. During follow-up he had persistently elevated transaminase levels and developed hepatosplenomegaly. An investigation was performed to determine the etiology of ongoing liver injury, including a liver biopsy which revealed hepatic cirrhosis. CONCLUSION Cirrhosis has rarely been reported with SDS. While many of the hepatic disorders associated with SDS improve with age, there are rare exceptions with serious implications for long-term outcome. | Sandra M Camacho Lucille McLoughlin Michael J Nowicki | 2019 | World Journal of Clinical Cases2019，7，12： | 2 |
| 5 | Defining biominerals and organominerals:Direct and indirect indicators of life 显示文摘 | Perry R S Mcloughlin N Lyrme B Y | 2007 | Sedimentary Geology2007，201，： | 1 |
| 6 | The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure显示文摘 | Olah TV McLoughlin DA Gilbert JD | 1997 | Rapid Commua Mass Spectrom1997，11，1： | 1 |
| 7 | An unusual case of spinal column metastasis after orthotopic transplantation for cardiac sarcoma显示文摘 | McLoughlin GS Sciubba DM Ali SK | | 0，，04： | 1 |
| 8 | Genome scale iden- tification of Treponema pallidum antigens 显示文摘 | McKevitt M Brinkman MB McLoughlin M | 2005 | Infect Immun2005，73，7： | 1 |
| 9 | Endoscopic argon plasma coagulation for the treatment of gastric antral vascular ectasia (watermelon stomach): long-term results显示文摘 | S Sebastian R McLoughlin A Qasim C.A O’Morain M.J Buckley | 2003 | Digestive and Liver Disease2003，，3： | 1 |
| 10 | Theoretical analysis of the MAX/Median filter显示文摘 | Arce G R McLoughlin M P | 1987 | IEEE Trans Acoust Speech Signal Processing1987，35，1： | 1 |
| 11 | DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis显示文摘 | Scholl FA McLoughlin P Ehler E | 2000 | J Cell Biol2000，151，3： | 1 |
| 12 | Hyperplasia of the mandibular coronoid process:An analysis of 31 cases and a review of the literature 显示文摘 | McLoughlin PM Hopper C Bowley NB | 1995 | J Oral Maxillofac Surg1995，53，： | 1 |
| 13 | Using web and problem-based learning envi-ronments to support the development of key skills显示文摘 | 01iverR McLoughlin C | 1999 | Ascilite1999，，1： | 1 |
| 14 | Bio-effects and safety of low-intensity,low-frequency ultrasonic exposure显示文摘 | Ahmadi F McLoughlin IV Chauhan S | | 0，，： | 1 |
| 15 | Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder显示文摘 | Lan M J McLoughlin G A Griffin J L | | 0，，03： | 1 |
| 16 | Resection of colorectal liver metastases current perspectives 显示文摘 | McLoughlin JM Jensen EH Malafa M | 2006 | Cancer Control2006，13，1： | 1 |
| 17 | The management of zygomatic complex fractures-results of a survey显示文摘 | Mcloughlin P Gilhooly M Wood G | 1994 | Br J Oral Maxillofac Surg1994，32，5： | 1 |
| 18 | GPS muhipath mitiga-tion:a nonlinear regression approach 显示文摘 | Phan Q H Tan S L Ian McLoughlin | 2013 | GPS Solut2013，17，： | 1 |
| 19 | En bloc total sacrectomy performed in a single stage through a posterior approach显示文摘 | McLoughlin GS Sciubba DM Suk I | 2008 | Neurosurgery2008，63，11： | 1 |
| 20 | Fossilized nu- clei and chromosomes reveal 180 million years of genomic stasis in royal ferns 显示文摘 | BOMFLEUR B MCLOUGHLIN S VAJDA V 2014 | 2014 | Science2014，343，6177： | 1 |
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