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| 1 | 2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。 | Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，1： | 6 |
| 2 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 3 | 美白牙膏去除牙齿外源性色斑的临床效果观察显示文摘目的 与仅含有 0 .32 1%氟化钠的牙膏相比 ,评价含有 0 .32 1%氟化钠及 2 0 %高清洁二氧化硅 (HCS)的牙膏减少外源性牙色斑的效果。方法 采用双盲、分层、二单位平行观察的临床研究方法。根据Lobene色斑指数均数 (色斑指数包括染色部位及染色程度 )、性别、将 15 8名年龄为 18~ 6 5岁的研究对象平衡地分为两组 ,随机地分配使用试验或对照牙膏。于基线、第 4周及第 8周固定由一名检查者完成研究对象的色斑指数测定。结果 4周时 ,使用美白牙膏的研究对象较对照组的牙齿色斑面积减少 17.4% ,染色程度减少 19.2 % (P <0 .0 1)。 8周时 ,使用美白牙膏的研究对象较对照组的牙齿色斑面积减少 38.6 % ,染色程度减少 39.6 % (P <0 .0 1)。结论 与对照组牙膏相比 ,使用含有 0 .32 1%氟化钠及 2 0 | 李雪 胡德渝 YP Zhang S Miller J Miller ME Petrone W Devizio AR Volpe | 2001 | 广东牙病防治2001，9，3： | 3 |
| 4 | Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease显示文摘 | De Leo ME Borrello S Passantino M | 1998 | Neurosci Lett1998，250，： | 2 |
| 5 | Introducing the clusterin gene into human renal cell carcinoma cells enhances their metastatic potential 显示文摘 | Miyake H Gleave ME Arakawa S | 2002 | J Urol2002，167，5： | 1 |
| 6 | Impingement and childhood hip disease显示文摘 | Wenger DR Kishan S Pring ME | 2006 | J Pediatr Orthop2006，15，4： | 1 |
| 7 | Diffusion tensor MR imaging Of high-grade cerebral gliomas显示文摘 | Sinha S Bastin ME Whittle IR | 2002 | AJNR2002，23，4： | 1 |
| 8 | The T-786->C mutation in endothelial nitric oxide synthase is associated with hypertension显示文摘 | Parsons HG Verma S | 2002 | Hypertension2002，39，4： | 1 |
| 9 | Diffusion tensor MR imaging of high - grade cerebral gliomas 显示文摘 | Sinha S Bastin ME Whittle IR | 2002 | AJNR2002，23，4： | 1 |
| 10 | A prospective, ran- domized study comparing laparoseopic ovarian cystectomy versus fenes- tration and coagulation in patients with endometriomas 显示文摘 | Alborzi S Momtahan M Parsanezhad ME | 2004 | Fertil Steril2004，82，6： | 1 |
| 11 | The effects of admission alcohol level on cerebral blood flow and outcomes after severe traumatic brain injury显示文摘 | Alexander S Kerr ME Yonas H | 2004 | J Neurotrauma2004，21，5： | 1 |
| 12 | Lupus anticoagulants: strong association with the major histocompatibility complex class II and platelet antibodies显示文摘 | Panzer S Pabinger I Gschwandtner ME | 1997 | Br J Haematol1997，98，： | 1 |
| 13 | Acetaldehyde increases the activity and gene expression of urokinase type plasminogen activator in a hepatic stellate cell line显示文摘 | Rodrīguez-Fragoso L Alvarez R Reyes-Esparza JA Garcés ME | 1999 | Toxicology1999，137，： | 1 |
| 14 | Akt activity in endometrial cancer ceils : regulation of cell survival through cIAP-1 显示文摘 | Gagnon V St-Germain ME Parent S | 2003 | Int J Oncol2003，23，3： | 1 |
| 15 | Imaging arterial wall disease显示文摘 | Hennerici M Me airs S | 2000 | Cerebrovase Dis2000，，： | 1 |
| 16 | Diffusion tensor MR imaging of high - grade Cerebral gliomas显示文摘 | Sinka S Bastin ME Whittle IR | 2002 | Am J Neuroradiol2002，23，4： | 1 |
| 17 | Chronic throidiris: a clinical and pathologic study of 354 patients显示文摘 | Lindsay S Dailey ME Eriedlander J | 1952 | Clin Endocrinal1952，12，4： | 1 |
| 18 | A proposed EGFR inhibitor dermatologic adverse event-specific grading scale from the MASCC skin toxicity study group 显示文摘 | LACOUTURE ME MAITLAND ML SEGAERTS S | 2011 | Support Care Cancer2011，19，： | 1 |
| 19 | Chemotherapy in women with advanced ovarian cancer 显示文摘 | Gordinier ME Dizon DS Weitzen S | 2007 | Palliat Med2007，10，1： | 1 |
| 20 | Preliminary outcomes and efficacy of the first 360 consecutive kyphoplasties for the treatment of painful osteoporotic vertebral compression frac- tures 显示文摘 | Majd ME Farley S Holt RT | 2005 | Spine J2005，5，： | 1 |
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