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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | In vitro toxicity of trichothecene on human erythroblastic progenitors 显示文摘 | Rio B Lautraite S and parent - Massin D | 1997 | Hum Exp Toxicol1997，16，： | 2 |
| 3 | Rendering and animation of gaseous phenomena by combining fast volume and seanline a-buffer techniques 显示文摘 | EBERT D S PARENT R E | 1990 | Computer Graphics1990，94，4： | 1 |
| 4 | Akt activity in endometrial cancer ceils : regulation of cell survival through cIAP-1 显示文摘 | Gagnon V St-Germain ME Parent S | 2003 | Int J Oncol2003，23，3： | 1 |
| 5 | Cryopreservation alters the levels of the bull sperm surface protein P25b显示文摘 | Parent S Leclerc P | 2000 | J Androl2000，21，5： | 1 |
| 6 | MRI signal distribution within the intcrvertcbral disc as a biomarker of adolescent idiopathic scoliosis and spondylolisthesis显示文摘 | Gervais J Pcrie D Parent S | 2012 | BMC Musculoskelet Disord2012，13，： | 1 |
| 7 | Comparison of the bi- omechanical 3D efficiency of different brace designs for the treatment of scoliosis using a finite element model显示文摘 | Clin J Aubin CE Parent S ei al | 2010 | Eur Spine J2010，19，7： | 1 |
| 8 | Thoracic pedicle morphometry in vertebrae from scoliotic spines显示文摘 | PARENT S LABELLE H SKALLI W | 2004 | Spine2004，29，： | 1 |
| 9 | Relationship between isocratic and gradient times in the high-performance ionexchange graphy of proteins theory and experiment 显示文摘 | PARENTE E S WETLAUFER D B | 1986 | J Chromatogr1986，355，： | 1 |
| 10 | Advanced lung adenocarcinoma in an EGFR-positive patient treated with Erlotinib for 52 months显示文摘 | Ivone Gon?alves Inês Ladeira Ana Castro Ana Antunes Ana Barroso Bárbara Parente | 2013 | Respiratory Medicine Case Reports2013，，： | 1 |
| 11 | Synthesis of graft copolymer derivatives of brominated poly (isobutylene-co-isoprene) 显示文摘 | Mclean J K Sergio A Parent J S | 2007 | European Polymer Journal2007，43，： | 1 |
| 12 | Issues and Approaches of Database Integration显示文摘 | Parent C Spaccapietra S | 1998 | Communications of the ACM1998，41，5： | 1 |
| 13 | Modelling Geographic Data with Multiple Representations显示文摘 | BALLEY S PARENT C SPACCAPIETRA S | 2004 | International Journal of Geographical Information Science2004，，： | 1 |
| 14 | X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization 显示文摘 | Van Themsche C Leblanc V Parent S | 2009 | J Biol Chem2009，284，20： | 1 |
| 15 | Sulfuration and re- version reactions of brominated poly (isobutylene-co-isoprene) 显示文摘 | Parent J S White G D F Thorn D J | 2003 | Journal of Polymer Science ( part A ) : Polymer Chemistry2003，41，13： | 1 |
| 16 | 肺动脉高压启动治疗后血流动力学指标的预后价值显示文摘血流动力学指标,如心脏指数和右心房压力(right atrial pressure,RAP)与患者确诊肺动脉高压时的生存率持续相关。近期研究表明,肺动脉顺应性(pulmon aryarterial compliance,Pea)也可能预测肺动脉高压的预后。而在治疗开始之后测定的血流动力学指标对预后的价值还未确定。 | 黄洁 叶鹏 Weatherald J Boucly A Chemla D Savale L Peng M Jevnikar M Ja?s X Taniguchi Y O'Connell C Parent F Sattler C Hervé P Simonneau G Montani D Humbert M Adir Y Sitbon O | 2017 | 中华高血压杂志2017，25，11： | 1 |
| 17 | Radical-mediated modification of polypropylene:Selective grafting via polyallyl coagents显示文摘 | Sengupta S S Parent J S Mclean J K | 2005 | Journal of Polymer Science (Part A):Polymer Chemistry2005，43，20： | 1 |
| 18 | Consumers knowledge under- standing and attitudes toword health Claims on food labels 显示文摘 | Fullmer S Geiger CJ Parent CR | 1991 | Am Diet Assoe1991，，2： | 1 |
| 19 | Resveratrol inhibits cisplatin-induced epithelial-to-mesenchymal transition in ovarian cancer cell lines显示文摘 | Baribeau S Chaudhry P Parent S | 2014 | PLoS One2014，9，86： | 1 |
| 20 | 1% tazarotene gel显示文摘 | Bershad S Kranjac Singer G Parente JE Successful treatment of acne vulgaris using a new method: results of a randomized vehicle-controlled trial of short-contact therapy with 0 | 2002 | Arch dermatol2002，138，： | 1 |
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