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| 1 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 2 | Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition显示文摘 | MEISTER S SCHUBERT U NEUBERT K | 2007 | Center Res2007，67，： | 1 |
| 3 | Genome expression analysis of Anopheles gambiae:responses to injury,bacterial challenge,and malaria infection 显示文摘 | Dimopoulos G Christophides G K Meister S | 2002 | Proceeding of National Academy of Science of United states of America2002，99，： | 1 |
| 4 | Current concepts in the rehabilitation of the overhead throwing athlete显示文摘 | Wilk KE Meister K Andrews JR | 2002 | Am J Sports Med2002，30，： | 1 |
| 5 | Quantum mechanical Carnot engine显示文摘 | Bender C M Brody D C Meister B K | 2000 | J Phys A2000，33，： | 1 |
| 6 | Determination of the principal directions of azimuthal anisotropy from P-wave seismic data 显示文摘 | Mallick S Craft K L Meister L J | 1998 | Geophysics1998，63，2： | 1 |
| 7 | Current concepts in the rehabilitation of overhead throwing athlete 显示文摘 | Wilk KE Meister K Andrews JR | 2002 | Am J Sports Med2002，30，2： | 1 |
| 8 | Rhabdomyolysis:an overview显示文摘 | Meister J Reddy K | 2002 | Am J Nurs2002，102，75： | 1 |
| 9 | Influence of the water content in dental enamel and dentin on ablation with the erbium YAG and YSGG lasers显示文摘 | Meister J Franzen R Forner K | 2006 | J Biomed Opt2006，11，3： | 1 |
| 10 | Determination of the principal directions of azimuthal anisotropy from P-wave seismicdata显示文摘 | Mallick S Craft K L Meister L J | 1998 | Geophysics1998，63，2： | 1 |
| 11 | Treatment of painful articular cartilage defects of the patella by carbon-fibre implants显示文摘 | Meister K Cobb A Bentley G | 1998 | J Bone Joint Surg Br1998，80，6： | 1 |
| 12 | Determination of the principal direction o{ azimuthal anisotropy from P-wave seismic data显示文摘 | Mallick S Craft K Meister L | 1998 | Geophysics1998，63，2： | 1 |
| 13 | Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition 显示文摘 | Meister S Schubert U Neubert K | 2007 | Cancer Res2007，67，4： | 1 |
| 14 | The risk for cross-re-actions after a cutaneous delayed-type hypersensitivity reaction toheparin preparations is independent of their molecular weight : asystematic review 显示文摘 | Weberschock T Meister AC Bohrt K | 2011 | Contact Dermatitis2011，65，4： | 1 |
| 15 | Determinalion of the principle direction of azimuthal nisotropy from P-wave seismie data 显示文摘 | MAKKUCK S CRAFT K L MEISTER l | 1998 | Geophysics1998，63，2： | 1 |
| 16 | Cytologically integrated physical restriction fragment length polymorphism maps for the barley genome based on translocation breakpoints显示文摘 | Künzel G Korzun L Meister A | 2000 | Genetics2000，154，1： | 1 |
| 17 | Nonirradiated versus irradiated achilles allograft: in vivo failure comparison 显示文摘 | Rappe M Horodyski M Meister K | 2007 | Am J Sports Med2007，10，： | 1 |
| 18 | Histology of the tornmeniscus: a comparisons of histologic differences in meniscal tis-sue between tears in anterior cruciate ligament-intact and anteriorcruciate ligament-deficient knees显示文摘 | Meister K Indelicato PA Spanier S | 2004 | Am J Sports Med2004，32，6： | 1 |
| 19 | Ex vivo expansion of hematopo ietic p rogenitor cells for clinical use显示文摘 | Scheding S Kratz Albers K Meister B | 1998 | Sem inHematol1998，35，4： | 1 |
| 20 | An archaebacterial to-poisomerase homolog not present in other eukaryotes is indispensable forcell proliferation of plants显示文摘 | HARTUNG F ANGELIS K J MEISTER A | 2002 | Curr Biol2002，12，20： | 1 |
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