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| 1 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 2 | Toward a contingency theory of compensation strategy 显示文摘 | BALKIN D B GOMEZ - MEJIA L R | 1987 | Strategic Management Journal1987，8，2： | 1 |
| 3 | Error Analysis and Attitude Observability of a Monocular GPS/Visual Odometry Integrated Navigation Filter 显示文摘 | DUSHA D MEJIAS L | 2012 | The International Journal o[ Robotics Research2012，31，6： | 1 |
| 4 | Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats 显示文摘 | Coch L Mejias M Berzigotti A | 2014 | Hepatology2014，60，2： | 1 |
| 5 | Compensation strategy: An overview and future steps 显示文摘 | Gomez Mejia L R Welbourne T M | 1988 | Human Resource Planning1988，11，3： | 1 |
| 6 | The role of family ties in agency contracts 显示文摘 | Gomez -Mejia L R Nunez -Nickel M Gutierrez I | 2001 | Academy of management Journal2001，44，1： | 1 |
| 7 | CEO Incentives, Inno- vation, and Performance in Technology- intensive Firms: A Recon- ciliation of Outcome and Behavior- based Incentive Schemes 显示文摘 | Makri M Lane P J Gomez - Mejia L R | 2006 | Strategic Management Journal2006，，11： | 1 |
| 8 | Biotransformation of natural and synthetic isoflavonoids by two recombinant microbial enzymes显示文摘 | Seeger M Gonzalez M Camara B Munoz L Ponce E Mejias L Mascayano C Vasquez Y epulveda-Boza S | 2003 | Appl Environ Microbiol2003，69，9： | 1 |
| 9 | Matching compensation and organization strategy 显示文摘 | BALKIN D B GOMEZ -MEJIA L R | 1990 | Strategic Management Journal1990，11，2： | 1 |
| 10 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 11 | Managerial compensation and firm performance: a general research framework 显示文摘 | Barkema H G Gomez- Mejia L R | 1998 | Academy of Management Journal1998，412，5： | 1 |
| 12 | Gain Sharing and Mutual Monitoring: A Combined Agency - organization- al Justice Interpretation 显示文摘 | WELBOURNE T M BALKIN D A GOMEZ - MEJIA L R | 1995 | Academy of Management Journal1995，38，3： | 1 |
| 13 | Neonatal diagnosis of a patient with hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR) syndrome associated with cerebral infarction 显示文摘 | Mejia JD Cervantes L Puerta H | 2014 | J Pediatr Endocrinol Metab2014，27，910： | 1 |
| 14 | Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells显示文摘 | Gao L Mejias R Echevarria M | 2004 | FEBS Lett2004，569，13： | 1 |
| 15 | Behavior of a Fine-grained Soil During Loma Prieta Earthquake显示文摘 | Boulanger R W Meyers M W Mejia L H | 1998 | Canadian Geoteehnical Journal1998，35，1： | 1 |
| 16 | Carotenoid content and vitamin-a activity of some common cultivars of Mexican peppers(Aapsicum annuum) as determined by HPLC显示文摘 | Mejia L A Hudson E Demejia E G | 1988 | Journal of Food Science1988，53，5： | 1 |
| 17 | Cross functional pay strategies in high - technology firms 显示文摘 | Coombs G Gomez - Mejia L R | 1991 | Compensation and Benefits Review1991，23，910： | 1 |
| 18 | EcologicalimplicatiorivS of anti-pathogen effects of tropical fugalendophytes and mycorrhizae 显示文摘 | Herre E A Mejia L Kyllo DA | 2007 | Ecology2007，88，3： | 1 |
| 19 | The decision of the supply chain executive to support or impede supply chain integration: A muhidisciplinary behavioral agency perspective显示文摘 | Villena V H Gomez Mejia L R Revilla E | 2009 | Decision Sciences2009，40，4： | 1 |
| 20 | Seismic upgrade of hydraulic fill dam by buttressing显示文摘 | Mejia L H Sun J I Leung K K | 2005 | Soil Dynamics and Earthquake Engineering2005，25，710： | 1 |
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