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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 3 | Toxic effects of L-DOPA on mesencephalic cell cultures: protection with antioxidants 显示文摘 | Mena MA Casarejos M J | 1995 | Brain Res1995，682，： | 1 |
| 4 | State of the Art on Automatic Road Extraction for GIS Update: A Novel Classification 显示文摘 | Mena J B | 2003 | Pattern Recognition Letters2003，24，16： | 1 |
| 5 | Role for the DOF transcription factor BPBF in the regulation of gibber- ellin responsive genes in barley aleurone 显示文摘 | Mena M Cejudo F J Isabel-Lamoneda I | 2002 | Plant Physi- o12002，130，： | 1 |
| 6 | Recent developments in numerical modelling of subsurface flow constructed Wetlands显示文摘 | Langergraber G Giraldi D Mena J | 2009 | Sci Total Environ2009，407，5： | 1 |
| 7 | Pineal region masses: differential diagnosis显示文摘 | Smimiotopoulos JG Rushing E J Mena H | 1992 | Radiographics1992，12，3： | 1 |
| 8 | The effects of varying gossypol intake from whole cottonseed and cottonseed meal on lactation and blood parameters in lactating dairy cows显示文摘 | Mena H Santos J E P Huber J T | 2004 | J Dairy Sci2004，87，： | 1 |
| 9 | Using image analy- sis in the study of multiphase gas absorption 显示文摘 | Mena P C Pons M N Teixeira J A | 2005 | Chemi- cal Engineering Science2005，60，18： | 1 |
| 10 | The Effects of Varying Gossypol Intake from Whole Cottonseed and Cottonseed Meal on Lactation and Blood Parameters in Lactating Dairy Cows 显示文摘 | Mena H J E P Santos J T Huber | 2004 | Dairy Sci2004，87，： | 1 |
| 11 | An automatic method for road extraction in rural and semi -urban areas starting from high resolution sat- ellite imagery 显示文摘 | J B Mena J A Malpiea | 2005 | Pattern Recognition Letters2005，26，3： | 1 |
| 12 | State of the art on automatic road extraction for GIS update:a novel classification显示文摘 | MENA J | 2003 | Pattern Recognition Letters2003，24，： | 1 |
| 13 | In vivo glutamine hydrolysis in the formation of extracellular glutamate in the injured rat brain显示文摘 | Mena F V Baab P J Zielke C L | 2000 | J Neurosci Res2000，60，5： | 1 |
| 14 | New or interesting hyphomycetes from the Biosphere Reserve of Sierra del Rosario, Cuba显示文摘 | Mena P J Delgado-Rodriguez G~ Mercado-Sierra A | 2001 | Mycologia2001，93，： | 1 |
| 15 | Biological permeable reactive barriers coupled with electrokinetic soil flushing for the treatment of diesel-polluted clay soil显示文摘 | Mena E Ruiz C Villasenor J | 2015 | Journal of Hazardous Materials2015，283，11： | 1 |
| 16 | The effects of varying gossypol intake from whole cottonseed and cottonseed meal on lactation and blood parameters in lactating dairy cows 显示文摘 | Mena H Santos J E P Huber J T | 2004 | Journal of Dairy Science2004，87，8： | 1 |
| 17 | State of the art on automatic road extraction for GIS update:a novel classification显示文摘 | MENA J B | 2003 | Pattern Recogni- tion Letters2003，24，16： | 1 |
| 18 | An automatic method forroad extraction in rural and semi-urban areas startingfrom high resolution satellite imagery显示文摘 | MENA J B MALPICA J A | 2005 | Pattern Recog-nition Letter2005，26，9： | 1 |
| 19 | The effects of feeding varying amounts of gossypol from whole cottonseed and cottonseed meal in lactating dairy cows显示文摘 | MENA H SANTOS J E HUBER J T | | 0，，10： | 1 |
| 20 | Intracranial hemangiopericytomas: MR and CT features 显示文摘 | Chiechi M Smirniotopoulos J G Mena H | 1996 | AJNR Am J Neuroradiol1996，17，7： | 1 |
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