|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma in the post-hepatitis C virus era: Should we change the paradigm?显示文摘Hepatocellular carcinoma (HCC) is a common and deadly malignancy. The disease usually develops on a background of chronic liver disease. Until recently, the most common etiology was infection with the hepatitis C virus (HCV). The advent of direct-acting antiviral (DAA) therapies has been a major breakthrough in HCV treatment. Sustained virologic response can now be achieved in almost all treated patients, even in patients with a high risk for the development of HCC, such as the elderly or those with significant fibrosis. Early reports raised concerns of a high risk for HCC occurrence after DAA therapy both in patients with previous resection of tumors and those without previous tumors. As the World Health Organization’s goals for eradication of HCV are being endorsed worldwide, the elimination of HCV seems feasible. Simultaneous to the decrease in the burden of cirrhosis from HCV, non-alcoholic fatty liver disease (NAFLD) incidence has been increasing dramatically including significant increased incidence of cirrhosis and HCC in these patients. Surprisingly, a substantial proportion of patients with NAFLD were shown to develop HCC even in the absence of cirrhosis. Furthermore, HCC treatment and potential complications are known to be influenced by liver steatosis. These changes in etiology and epidemiology of HCC suggest the beginning of a new era: The post–HCV era. Changes may eventually undermine current practices of early detection, surveillance and management of HCC. We focused on the risk of HCC occurrence and recurrence in the post–HCV era, the surveillance needed after DAA therapy and current studies in HCC patients with NAFLD. | Hadar Meringer Oren Shibolet Liat Deutsch | 2019 | World Journal of Gastroenterology2019，25，29： | 6 |
| 2 | Fast generation of regular graphs and construction of cages显示文摘 | MERINGER M | | 0，，30： | 1 |
| 3 | Toward automatic reconstruction of a highly resolved tree of life显示文摘 | Ciccarelli FD Doerks T Von Mering | | 0，，5765： | 1 |
| 4 | Balloon angioplasty versus bypass grafting in the era of coronary stenting显示文摘 | Ekstein S Elami A MerinG | 2002 | Isr Med Assoc2002，4，8： | 1 |
| 5 | y-Randomization and its variants in QSPR/QSAR 显示文摘 | Rucker C Rucker G Meringer M | 2007 | J Chem Inf Model2007，47，6： | 1 |
| 6 | STRING:known and predicted protein-protein associations,integrated and transferred across organisms显示文摘 | von Mering C Jensen L J Snel B | | 0，，： | 1 |
| 7 | Systolic compression of the left anterior descending coronary artery:a case series,review of the literature,and therapeutlc options including stenting显示文摘 | Berry JF yon Mering GO Schomalfuss C | | 0，，01： | 1 |
| 8 | MOLGEN-QSPR, a Software Package for the Study of Quantitative Structure-property Relationships显示文摘 | Kerber A Laue R Meringer M | 2004 | Match Commun Math Comput Chem2004，51，： | 1 |
| 9 | Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women:results from the National Heart,Lung,and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)显示文摘 | von Mering G O Arant C B Wessel T R | | 0，，06： | 1 |
| 10 | Abnormal coronary vasomotion as a prognostic indicator of cardiovascular event in women显示文摘 | von Mering GO Arant CB Wessel TR | | 0，，06： | 1 |
| 11 | Similarity of molecular descriptors: the equivalence of Zagreb indices and walk counts 显示文摘 | BRAUN J KERBER A MERINGER M | 2005 | Match Commun Math Comput Chem2005，54，： | 1 |
| 12 | The Use of MS Classifiers and Structure Generation to Assist in the Identification of Unknowns in Effect- directed Analysis 显示文摘 | Schymanski E L Meinert C Meringer M | 2008 | Anal Chim Acta2008，615，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员