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| 1 | Humanized mice are susceptible to Salmonella typhi infection显示文摘Salmonella enterica serovar Typhi is a pathogen that only infects humans.Currently,there is no animal model for studying this pathogen.Recently,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C virus.Little is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as S.typhi.The aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized mice.Here we report that intravenous inoculation of S.typhi into humanized mice,but not controls,established S.typhi infections.High bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control mice.Importantly,S.typhi-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological symptoms.Our data suggest,for the first time,that humanized mice are susceptible to S.typhi challenge and that this model can be utilized to study the pathogenesis of S.typhito develop novel therapeutic strategies. | M Firoz Mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar | 2011 | Cellular & Molecular Immunology2011，8，1： | 2 |
| 2 | Tall fescue genomic SSR markers:development and transferability across multiple grass species 显示文摘 | SAHA M C COOPER J D ROUF MIAN M A | 2006 | Theor Appl Genet2006，113，： | 1 |
| 3 | QTLs conditioning early growth in a soybean population segregation for growth habit 显示文摘 | Mian M A R Ashley D A Vencill WK et at | 1998 | Theoretical and Applied Genetics1998，97，8： | 1 |
| 4 | Cutting edge:FimH adhesin of type 1 fimbriae is a novel TLR4 ligand显示文摘 | Mossman K L Mian M F Lauzon N M | 2008 | J Immunol2008，81，10： | 1 |
| 5 | RFLP analysis of chlorimuron ethyl sensitivity in soybean显示文摘 | Mian M R Shipe E R Alvernaz J | 1997 | Journal of Heredity1997，88，： | 1 |
| 6 | An EfficientMultimodal 2D-3D Hybrid Approach to Automatic FaceRecognition显示文摘 | MIAN A S BENNAMOUN M OWENS R | 2007 | IEEE Transactions on Pattern Analysisand Machine Intelligence2007，29，11： | 1 |
| 7 | Role of radiotherapy in patients with early-stage diffuse large B-cell lymphoma of Waldeyer's ring in remission after anthracycline-containing chemotherapy显示文摘 | Mian M Ferreri A J Rossi A | 2013 | Leuk Lymphoma2013，54，1： | 1 |
| 8 | Melecularmarkers associated with water use efficiency and leafash in soybean显示文摘 | MIAN M A R BAILEY M A ASHLEY D D | 1996 | Crop Sci1996，36，： | 1 |
| 9 | A microwell array system for stem cell culture显示文摘 | Moeller HC Mian M Shrivastava S | 2008 | Biomaterials2008，29，6： | 1 |
| 10 | The IrrE Protein of Deinococeus radiodurans R1 is a novel regulator of reeA expression 显示文摘 | Ashlee M Earl Michael M Mohundro Saira Mian I John R Battista | 2002 | J Bacteriol2002，184，： | 1 |
| 11 | Tissue architec- ture : the ultimate regulator of breast epithelial function 显示文摘 | BISSELL M J RIZKI A MIAN I S | 2003 | Current Opinion in Cell Biology2003，15，6： | 1 |
| 12 | Differ- ential gene expression in Festuca under heat stress con- ditions 显示文摘 | ZHANG Y MIAN M A R CHEKHOVSKIY K | 2005 | Journal of Experimental Botany2005，56，413： | 1 |
| 13 | Molecu- lar markers associated with seed weight in two soybean populations显示文摘 | Mian M A R Bailey M A Tamulonis J P | 1996 | Theor Appl Genet1996，93，： | 1 |
| 14 | Tall fescue EST-SSR markers with transferability across several grass species显示文摘 | Saha M C Mian M A Eujayl I | 2004 | Theoretical and Applied Genetics2004，109，4： | 1 |
| 15 | Tailings erosion and resuspension in two mine tailings ponds due to wind waves显示文摘 | MIAN M H YANFUL E K | 2003 | Advances in Environmental Research2003，7，4： | 1 |
| 16 | uCyt+ test:altemative to cystoscopy for less-invasive follow-up of patients with low risk of urothelial carcinoma显示文摘 | Lodde M Mian C Comploj E Palermo S Longhi E Marberger M | | 0，，： | 1 |
| 17 | uCyt+/ImmunoCyt in the detection of recurrent urothelial carcinoma:an update on,1991 analyses显示文摘 | Mian C Maier K Comploj E Lodde M Bemer L Lusuardi L | | 0，，： | 1 |
| 18 | Molecular markers associat-ed with soybean plant height,lodging and maturity across locations显示文摘 | Lee S H Bailey M A Mian M A | 1996 | Crop Science1996，36，： | 1 |
| 19 | Increased serum stromelysin-1 levels in systemic lupus erythematosus:lack of correlation with disease activity显示文摘 | Zucker S Mian N Drews M | 1999 | J Rheumatol1999，26，1： | 1 |
| 20 | Increased angiotensin Ⅱ type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits显示文摘 | Baichun CY MIan Phillip Dagmara M | 1998 | Arerioscler Thromb Vasc Biol1998，18，： | 1 |
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