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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Numerical analysis and thermographic investigation of induction heating显示文摘	Matej Kranjc Anze Zupanic Damijan Miklavcic Tomaz Jarm	2010	International Journal of Heat and Mass Transfer2010，，17：	2
3	Time course of transmembrane voltage induced by time-varying electric field: a method for theoretical analysis and its application显示文摘	Tadej Kontik Damijan Miklavcic Tomaz Slivnik	1998	Bioelectrochemistry and Bioenergetics1998，45，：	1
4	Theoretical evaluation of voltage inducement on internal membranes of biological cells exposed to electric fields显示文摘	Kotnik T Miklavcic D	2006	Biophysical Journal2006，90，2：	1
5	Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with ciplatin 显示文摘	Cemazar M Miklavcic D An D	1999	Br J Cancer1999，79，910：	1
6	Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin显示文摘	Cemazar M Miklavcic D Scancar J	1999	Br J Cancer1999，79，910：	1
7	Numerical analysis and thermographic investigation of induction heating 显示文摘	Kranjc M Zupanic A Miklavcic D	2010	International Journal of Heat and Mass Transfer2010，53，：	1
8	Nume- rical Analysis and Thermographic Investigation of Induction Heating显示文摘	Matej Kranjc Anze Zupanic Damijan Miklavcic	2010	International Journal of Heat and Mass Trans- fer2010，53，1718：	1
9	Numerical analysis and thermographic investigation of in- duction heating 显示文摘	Matej Kranjc Anze Zupanic Damijan Miklavcic	2010	International Journal of Heat and Mass Transfer2010，，53：	1
10	Revised Kubelka-Munk theory: Ⅱ A study of ink penetration in ink--jet printing 显示文摘	Yang L Kruse B Miklavcic S J	2004	Journal of the Optical Society of America2004，21，10：	1
11	Revised Kubel- ka-Munk theory: II A study of ink penetration in ink-jet printing 显示文摘	Yang L Kruse B Miklavcic S J	2004	J Opt Society of America2004，21，10：	1
12	The importance of electric field distribution for effective in vivo eleetroporation of tissues显示文摘	Miklavcic D Beravs K Semrov D	1996	BiophysJ1996，74，5：	1
13	Numerical modeling and optimization of electric field distribution in subcutaneous tumor treated with electrochemotherapy using needle electrodes显示文摘	Corovic S Zupanic A Miklavcic D	2008	IEEE Transactions on Plasma Science2008，36，4：	1
14	Time course of transmembrane voltage induced by time-varying electric fields-a method for theoretical analysis and its application 显示文摘	Kotnik T Miklavcic D Slivnik T	1998	Bioelectrochem Bioenerg1998，45，：	1
15	Cellcell electrofusion:optimization of electric field amplitude and hypotonic treatment for mouse melanoma (B16-F1)and Chinese Hamster ovary (CHO) cells显示文摘	USAJ M TRONTELJ K MIKLAVCIC D		0，，01：	1
16	Revised Kubelka-munk theory: Ⅱ a study of ink penetration in ink-jet printing显示文摘	YANG L Kruse B Miklavcic S J	2004	Journal of the Optical Society of America2004，21，10：	1
17	Importance of turnout coverage by sufficiently high local electric field for effective electrochemotherapy显示文摘	Damijan Miklavcic Selma Corovic Gorazd Pucihar	2006	EJC Supplements2006，4，：	1
18	A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy显示文摘	Miklavcic D Semrov D Mekid H	2004	Biochim Biophys Acta2004，1523，：	1
19	Optimization of electrode position and electric pulse amplitude in electrochemotherapy 显示文摘	Zupanic A Corovic S Miklavcic D	2008	RadiolOncol2008，42，2：	1
20	Induced transmembrane voltage and its correlation with electroporation-mediated molecular transport显示文摘	Kotnik T Pucihar G Miklavcic D	2010	J Membr Biol2010，236，：	1

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