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| 1 | Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-γ production显示文摘AIM: To investigate the capacity of potentially probiotic strains from six bacterial genera to induce cytokine production alone or in combinations in order to identify potential enhancing or synergistic effects in order to select probiotic bacteria for in vivo purposes. METHODS: Cytokine production in human peripheral blood mononuclear cells (PBMC) in response to stimulation with eleven different potentially probiotic bacterial strains from Streptococcus , Lactobacillus , Bifidobacterium , Lactococcus , Leuconostoc and Propionibacterium genera was analysed. Production and mRNA expression of TNF-α, IL-12, IFN-γ and IL-10 were determined by ELISA and Northern blotting, respectively. RESULTS: All tested bacteria induced TNF-α production. The best inducers of Th1 type cytokines IL-12 and IFN-γ were Streptococcus and Leuconostoc strains. All Bifidobacterium and Propionibacterium strains induced higher IL-10 production than other studied bacteria. Stimulation of PBMC with any bacterial combinations did not result in enhanced cytokine production suggesting that different bacteria whether gram-positive or gram- negative compete with each other during host cell interactions.CONCLUSION: The probiotic S. thermophilus and Leuconostoc strains are more potent inducers of Th1 type cytokines IL-12 and IFN-γ than the probiotic Lactobacillus strains. Bacterial combinations did not result in enhanced cytokine production. | Riina A Kekkonen Elina Kajasto Minja Miettinen Ville Veckman Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，8： | 9 |
| 2 | Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells显示文摘AIM:To investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.METHODS:Human peripheral-blood-derived mast cells were stimulated with Lactobacillus rhamnosus (L.rhamnosus) GG (LGG),L.rhamnosus Lc705 (Lc705),Propionibacterium freudenreichii ssp.shermanii JS (PJS) and Bifidobacterium animalis ssp.lactis Bb12 (Bb12) and their combination for 3 or 24 h,and were subjected to global microarray analysis using an Affymetrix GeneChip Human Genome U133 Plus 2.0 Array.The gene expression differences between unstimulated and bacteria-stimulated samples were further analyzed with GOrilla Gene Enrichment Analysis and Visualization Tool and MeV Multiexperiment Viewer-tool.RESULTS:LGG and Lc705 were observed to suppress genes that encoded allergy-related high-affinity IgE receptor subunits α and γ (FCER1A and FCER1G,respectively) and histamine H4 receptor.LGG,Lc705 and the combination of four probiotics had the strongest effect on the expression of genes involved in mast cell immune system regulation,and on several genes that encoded proteins with a pro-inflammatory impact,such as interleukin (IL)-8 and tumour necrosis factor alpha.Also genes that encoded proteins with anti-inflammatory functions,such as IL-10,were upregulated.CONCLUSION:Certain probiotic bacteria might diminish mast cell allergy-related activation by downregulation of the expression of high-affinity IgE and histamine receptor genes,and by inducing a pro-inflammatory response. | Anna Oksaharju Matti Kankainen Riina A Kekkonen Ken A Lindstedtt Petri T Kovanen Riitta Korpela Minja Miettinen | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 3 | Ocular anatomy and cross-sectional imaging of the eye显示文摘 | Malhotra A Minja F J Crum A | 2011 | Semin Ultrasound CT MR2011，32，1： | 1 |
| 4 | Functional re- sults following vescica ileale Padovana (VIP) neobladder: midt- errn follow-up analysis with validated questionnaires显示文摘 | NOVARA G FICARRA V MINJA A | 2010 | Eur Urol2010，57，6： | 1 |
| 5 | The use of Toddalia asiatica (L) Lam ( Rutaceae ) in traditional medicine practice in East Africa 显示文摘 | Orwa J A Jondiko I J O Minja R J A | 2008 | Journal of Ethno- pharmacology2008，115，： | 1 |
| 6 | Pumice soil:A Potential Wetlands Substrate for Treatment of Domestic Wastewater显示文摘 | Njau K N Minja R J A KatimaJ H Y | 2003 | Water Science and Technology2003，48，5： | 1 |
| 7 | A Potential Wetlands Substrate for Treatment of Domestic Wastewater显示文摘 | Nj au K N Minja R J A Katima JH Y | 2003 | Water Science and Technology2003，48，5： | 1 |
| 8 | A low-noisewideband digital phase-locked loop based on a coarse-fine time-to-digital converter with subpicosecond reso-lution 显示文摘 | Minjae Lee? Heidari M E Abidi A A | 2009 | IEEE Journal of Solid-state Circuits2009，10，44： | 1 |
| 9 | Doppler-free Stark spectroscopy of the second excited level of atomic hydrogen for measurements of electric felds显示文摘 | Minja G A Andreas S Klaus G | 2007 | Phys Rev A2007，75，1： | 1 |
| 10 | Functional results following vescica ileale Padovana (VIP) neobladder: midterm follow-up analysis with validated questionnaires 显示文摘 | Novara G Ficarra V Minja A | 2010 | Eur Urol2010，57，6： | 1 |
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