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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | NOx trapping and soot combustion on BaCoO3-y pemvskite:LRS and FFIR characterization显示文摘 | Mih V G Ulla M A Mira E E | 2005 | Applied Catalysis B : Environmental2005，57，1： | 1 |
| 3 | Forced expression of MMP9 rescues the loss of angiogenesis andabrogates metastasis of pancreatic tumors triggered by the absence ofhost SPARC显示文摘 | Arnold S Mira E Muneer S Korpanty G Beck AW Holloway SE etal | 2008 | Exp Biol Med(Maywood)2008，233，： | 1 |
| 4 | Microscopic characterization of follicular structures in letrozole-induced polycystic ovarian syndrome in the rat显示文摘 | Baravalle C Salvetti N R Mira G A | 2006 | Arch Med Res2006，37，7： | 1 |
| 5 | Statins inhibit HIV - 1 infection by down - regulating rho activity 显示文摘 | del Real G Jimenez - Baranda S Mira E | 2004 | J Exp Med2004，200，： | 1 |
| 6 | Betahistine dihydrochlo- ride in the treatment of peripheral vestibular vertigo显示文摘 | Mira E Guidetti G Ghilardi L | 2003 | Eur Arch Otorhinolaryngol2003，260，2： | 1 |
| 7 | Finite-time global chaos synchronization for piecewise linear maps显示文摘 | Millerioux G Mira C | 2001 | IEEE Trans Circuits Syst Ⅰ2001，48，： | 1 |
| 8 | Finite-time global chaos synchronization for piecewise linear maps显示文摘 | Millerioux G Mira C | 2001 | IEEE Trans on Circuits System I2001，48，1： | 1 |
| 9 | Face-directed self-assembly of an electronically active Archimedean polyoxometalate architecture 显示文摘 | Mitchell S G Streb C Miras H N | 2010 | Nat Chem2010，2，： | 1 |
| 10 | Redox coupled ion exchange in Cobalt oxide films显示文摘 | Barbero C Planes G A Miras M C | 2001 | Electrochemistry Communications2001，3，3： | 1 |
| 11 | Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal显示文摘 | Deqiang Sun Min Luo Mira Jeong Benjamin Rodriguez Zheng Xia Rebecca Hannah Hui Wang Thuc Le Kym F. Faull Rui Chen Hongcang Gu Christoph Bock Alex Meissner Berthold G?ttgens Gretchen J. Darlington Wei Li Margaret A. Goodell | 2014 | Cell Stem Cell2014，，： | 1 |
| 12 | Iron and zinc grain density in common wheat grown in Central Asia显示文摘 | Alexei Morgounov Hugo Ferney Gómez-Becerra Aigul Abugalieva Mira Dzhunusova M. Yessimbekova Hafiz Muminjanov Yu Zelenskiy Levent Ozturk Ismail Cakmak | 2007 | Euphytica (-)2007，，1： | 1 |
| 13 | Removal of pharma- ceuticals during wastewater treatment and environmental risk assessment using hazard indexes显示文摘 | Meritxell G Mira P Antoni G | 2010 | Environ Inter2010，36，： | 1 |
| 14 | The importance of Toll-like receptor 2 polymor- phisms in severe infeetions显示文摘 | Texereau J Chiche JD Taylor W Choukroun G Comba B Mira JP | 2005 | Clin Infect Dis2005，41，7： | 1 |
| 15 | 2014, Effects of land-use change on wetland ecosystem services: A case study in the Donana marshes (SW Spain) 显示文摘 | MIRAS P Z PALOMO I BAGGETHUN E G | 2014 | Landscape and Urban Planning2014，122，： | 1 |
| 16 | Statins inhibit HIV-1infection by down-regulating Rho activity显示文摘 | delReal G Jimenez-Baranda S Mira E | 2004 | J Exp Med2004，200，4： | 1 |
| 17 | Statins inhibit HIV-1 infection by down-regulation Rho activity显示文摘 | Del Real G Jimenez-Baranda S Mira E | 2004 | J Exp Med2004，200，4： | 1 |
| 18 | Statins inhibit HIV-I infection by down-regulating Rho activity显示文摘 | del Real G Jimcnez-Baranda S Mira E | 2004 | J Exp Med2004，200，4： | 1 |
| 19 | Heat shock protein 70 and sex steroid receptors in the follicular structures of induced ovarian cysts 显示文摘 | SALVETTI N R BARAVALLE C MIRA G A | 2009 | Reprod Domest Anim2009，44，5： | 1 |
| 20 | Statins inhibit HIV-1 infection by down-regulating Rho activity显示文摘 | del Real G Jimenez-Baranda S Mira E | 2004 | J Exp Med2004，200，4： | 1 |
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