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| 1 | A deep learning-enabled portable imaging flow cytometer for cost-effective, highthroughput, and label-free analysis of natural water samples显示文摘We report a deep learning-enabled field-portable and cost-effective imaging flow cytometer that automatically captures phase-contrast color images of the contents of a continuously flowing water sample at a throughput of 100 mL/h.The device is based on partially coherent lens-free holographic microscopy and acquires the diffraction patterns of flowing micro-objects inside a microfluidic channel.These holographic diffraction patterns are reconstructed in real time using a deep learning-based phase-recovery and image-reconstruction method to produce a color image of each micro-object without the use of external labeling.Motion blur is eliminated by simultaneously illuminating the sample with red,green,and blue light-emitting diodes that are pulsed.Operated by a laptop computer,this portable device measures 15.5 cm×15 cm×12.5 cm,weighs 1 kg,and compared to standard imaging flow cytometers,it provides extreme reductions of cost,size and weight while also providing a high volumetric throughput over a large object size range.We demonstrated the capabilities of this device by measuring ocean samples at the Los Angeles coastline and obtaining images of its micro-and nanoplankton composition.Furthermore,we measured the concentration of a potentially toxic alga(Pseudo-nitzschia)in six public beaches in Los Angeles and achieved good agreement with measurements conducted by the California Department of Public Health.The cost-effectiveness,compactness,and simplicity of this computational platform might lead to the creation of a network of imaging flow cytometers for largescale and continuous monitoring of the ocean microbiome,including its plankton composition. | Zoltán Gӧrӧcs Miu Tamamitsu Vittorio Bianco Patrick Wolf Shounak Roy Koyoshi Shindo Kyrollos Yanny Yichen Wu Hatice Ceylan Koydemir Yair Rivenson Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 14 |
| 2 | Study of interleukin - 6 production in Alzheimers disease 显示文摘 | Cojocaru IM Cojoearu M Miu G | 2011 | Rom J Intern Med2011，49，1： | 1 |
| 3 | Experimental and numerical analysis of read/write head suspension dynamics for high-performance floppy drive Systems显示文摘 | Miu D K | 1990 | Journal of Vibration Acoustics Stress and Reliability in Design1990，112，1： | 1 |
| 4 | Capacitor placeme-nt,replacement and control in large-scale distribution systems by a GA-based two-stage algorithm显示文摘 | Miu K N Chiang H D Darling G | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 5 | Capacitor placement,replacement and control in large-scale distribution system by a GA-based two-stage algorithm显示文摘 | Miu K N Chiang Hsiao-Dong Daring G | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 6 | Experimental and numerical analysis of read/write head suspension dynamics for high-performance floppy drive systems显示文摘 | | 1990 | Journal of Vibration Acoustics Stress and Reliability in Design1990，112，1： | 1 |
| 7 | Study of interleukin-6 production in Alzheimer's disease显示文摘 | Cojocaru IM Cojocaru M Miu G | 2011 | Rom J Intern Med2011，49，1： | 1 |
| 8 | Sinistral to normal faulting along the Tan-Lu Fault Zone:evidence for geodynamic switching of the East China Continental Margin显示文摘 | Zhu G Miu M L Xie C L Wang Y S | | 0，，03： | 1 |
| 9 | 显示文摘 | Sinenchenko G I Kabanov MIu Tikhonchuk S V | 2004 | Vestn Khir Im I I Grek2004，163，： | 1 |
| 10 | Decomposition of Parathion in Aqueous Solution by Ultrasonic Irradiation显示文摘 | KOTRONARON MIUS G MICHAEL R Hoffmann | 1992 | Environ Sci Technol1992，26，7： | 1 |
| 11 | Sonochemical degradation of p-Nitrophenol in the presence of chemical components of natural water显示文摘 | MIUS G | 1992 | Chemosphere1992，27，9： | 1 |
| 12 | Capacitor placement, replacement and control in large-scale distribution systems by a GA-based two-stage algorithm显示文摘 | Miu K N Chiang H-D Darling G | 1997 | IEEE Trans on Pow- er Systems1997，12，3： | 1 |
| 13 | Experimental and Numerical Analysis of Read/ Write head Suspension Dynamics for High - performance Floppy Drive Systems 显示文摘 | FRESS G M MIU D K | 1990 | Journal of Vibration Acoustics Stress and Reliability in Design1990，112，1： | 1 |
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