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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 过度表达的内皮素1通过改变氧化应激加重糖尿病诱导的内皮功能障碍显示文摘内皮素1表达增加引起内皮功能障碍和氧化应激。通常糖尿病患者体内的血浆内皮素1水平增加。鉴于糖尿病患者的内皮功能障碍常先于血管并发症,研究者假设在血管内皮细胞中,内皮素1的过度表达会加莺糖尿病引起的血管内皮功能障碍。 | Idris-Khodja N Ouerd S Mian MO Gornitsky J Barhoumi T Paradis P Schiffrin EL 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 3 | Complete nucleotide sequence and genome organization of a chinese isolate of tobacco vein distorting virus 显示文摘 | MO X H CHEN Z B CHEN J P | 2010 | Virus Genes2010，41，3： | 1 |
| 4 | Attenuated apoptosis of B cell activating factor-expressing cells in primary sjgren's syndrome显示文摘 | Szodoray P Jellestad S Teague MO | 2003 | Lab Invest2003，83，3： | 1 |
| 5 | Petri net modeling and design of task oriented messaging system for robot control显示文摘 | Mo John P T Tang Bryan C K | 1998 | Computers & Industrial Engineering1998，34，4： | 1 |
| 6 | Complete genome se- quences of two Chinese virulent avian coronavirus infec- tious bronchitis virus variants 显示文摘 | Mo M Huang B Wei P | 2012 | J Virol2012，86，10： | 1 |
| 7 | Biochemical complementation of chalcone synthase mutants defines a role for flavonols in functional pollen显示文摘 | Mo Y Nagel C Taylor L P | 1992 | Proceedings of the National Academy of Sciences1992，89，15： | 1 |
| 8 | Environmental and economic costs of soil erosion and conservation benefits显示文摘 | Pim entel D Harvey C Resos udar mo P | 1995 | Science1995，267，： | 1 |
| 9 | Markers of cardiovascular remodeling in hypertension显示文摘 | Legedz L Rial MO Lantelme P | 2003 | Arch Mal Coeur vaiss2003，96，78： | 1 |
| 10 | Investigation of the conductivity of asphalt concrete containing conductive fillers 显示文摘 | WU S P MO L T SHUI Z H | 2005 | Carbon2005，43，： | 1 |
| 11 | 显示文摘 | Mo Y G Dillon R O Snyder P G | 1999 | Thin Solid Films1999，355，： | 1 |
| 12 | NMR structural analysis of alpha2bungaro toxin and its complex w ith the p rincipal alpha-neuro toxin binding sequence on the alpha-subunit of a neuronal nicotinic acetylcho line receptor显示文摘 | Mo ise L P iserch io A Basus V J | 2002 | J Biol Chem2002，277，12： | 1 |
| 13 | 查看详情显示文摘 | MO Y R BAO P GAO J L | | 0，，： | 1 |
| 14 | Serum zinc,insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with type 1 diabetes mellitus显示文摘 | Bideci A Camurdan MO Cinaz P | | 0，，10： | 1 |
| 15 | A supramodal number repre- sentation in human intraparietal cortex 显示文摘 | Eger E Sterzer P Russ MO | 2003 | Neuron2003，37，4： | 1 |
| 16 | Apoptotic effects of antimalarial ar- temisinin on the second generation merozoites of Eimeria tenella and parasitized host ceils 显示文摘 | MO P MA Q ZHAO X | 2014 | Vet Parasitol2014，206，34： | 1 |
| 17 | 2D and 3D meso-scale finite element models for ravelling analysis of porous asphalt concrete显示文摘 | MO L T HUURMAN M WU S P | 2008 | Finite Elements in Analysis and Design2008，，44： | 1 |
| 18 | Distinct proteolytic processes generate the C and N termini of MHC class Ⅰ-binding peptides 显示文摘 | Mo XY Cascio P Lemerise K | 1999 | J Immunol1999，163，11： | 1 |
| 19 | Relationship between expression of KAI1 m3etastasis suppressor gene,mRNA levers and p53 in human bladder and pristate cancer cell lines显示文摘 | Jackson P Grimm MO Kingsley EA | 2002 | Urol Oncol2002，7，3： | 1 |
| 20 | Detection and Control of Aspartimide Formation Cyclic Peptides 显示文摘 | Flora D MO Huaping Mayer J P | 2005 | Bioorganic and Medicinal Chemistry Letters2005，15，4： | 1 |
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