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| 1 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 2 | Differential effects of Pentoxfylline on the hepatic inflammatory response in porcine liver cell cultures increase in inducible nitric oxide synthase expression显示文摘 | Hoebe K H Gonza1ez R αmon N Nijmeijer S M | 2001 | Biochem pharmacol2001，61，9： | 1 |
| 3 | Simultaneous component sequencing and feeder assignment for high speed chip shooter machines显示文摘 | MON YER L K GUPTA S M | 1996 | Journal of Electronics Manufacturing [J]1996，6，4： | 1 |
| 4 | Numerical study of fin-spacing effects in annular-finned tube heat exchangers显示文摘 | Mon M S Gross U | | 0，，8： | 1 |
| 5 | Numerical study of fin spacing effects in annular-finned tube heat exchangers 显示文摘 | MON M S GROSS U | 2004 | International Journal of Heat and Mass Transfer2004，47，89： | 1 |
| 6 | Basic laws of Turbulent Mixing in the ground layer of the atmosphere 显示文摘 | Mon in A S Obukhov A M | 1954 | Trans Geophys Inst Akad Nauk1954，151，4： | 1 |
| 7 | Heat Exchanger Design显示文摘 | Than S T M Lin K A Mon M S | 2008 | World A- cademy of Science Engineering and Technology2008，46，： | 1 |
| 8 | Spatial memory in the Morris water maze and activation of cyclic AMP response element-binding(CREB) protein within the mouse hippocampus显示文摘 | Porte Y Buhot M C Mons N S | 2008 | Learn Mem2008，15，12： | 1 |
| 9 | Retinal vein occlusions显示文摘 | Jonas J Paques M Mon é s J | 2010 | Dev Ophthalmol2010，47，： | 1 |
| 10 | Over expression of Sel-enocysteine methyltransferase in Arabidopsis and Indian mustard in- creases selenium tolerance and accumulation 显示文摘 | LEDUC D L TARUN A S MON'IS-BAYON M | 2004 | Plant Physiology2004，135，1： | 1 |
| 11 | Por- ous tantalum and poly-epsilon-caprolactone biocompos- ites for osteochondral defect repair: preliminary studies in rabbits显示文摘 | Mrosek E H Schagemann J C Chung H W Fitzsim- mons J S Yaszemski M J Mardones R M | 2010 | J Orthop Res2010，28，： | 1 |
| 12 | Growing Prof itable or Growing from Prof its:Putting the Horse in front of the Cart-显示文摘 | Dav id s s on P S t e f fe n s P F it z s i m mon sJ | 2009 | Journal ofBusiness Venturing2009，24，4： | 1 |
| 13 | Mutations in oxyR resulting in peroxide resistance in Xan- thomonas campestris显示文摘 | MON~GKOKSuK S WHANGSUK W FUANGTHONG M | 2000 | Journal of Bacteriology2000，182，13： | 1 |
| 14 | Ex- pression of interleukin- 8 and not parathyroid hormone- related protein by human breasl cancer cells correlates with bone metastasis in vivo 显示文摘 | BENDRE M S GADDY -KURTEN D MON - FOOTE T | 2002 | Cancer Res2002，62，19： | 1 |
| 15 | An applied printing immunoassay with recombinant Nc-SAG1 for detection of antibodies to Neospora caninum in cattle 显示文摘 | Wilkowsky S E Bareiro G G Mon M L | 2011 | J Vet Diagn Invest2011，23，5： | 1 |
| 16 | Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes显示文摘BACKGROUND The regulatory factor X6 (RFX6), a member of regulatory factor X family, is known to play a key role in the development and differentiation of pancreatic beta cells as well as insulin production and secretion. However, the potential role of RFX6 in type 2 diabetes (T2D) is still unclear. AIM Recent studies have indicated that RFX6 binding to DNA could be disrupted in diabetes. Therefore, in this study we investigated whether genetic mutations are present in the DNA binding domain of RFX6 gene that could abrogate its function in T2D. METHODS A cohort of T2D patients was enrolled in this study, and the gene encoding the DNA binding domain of RFX6 was amplified by polymerase chain reaction and then analysed by direct DNA sequencing. RESULTS The DNA sequence analysis revealed the absence of any exonic mutation. However, we have identified a new heterozygous single nucleotide polymorphism (IVS6+31 C>T) in the intronic region of DNA binding domain gene that is present in 9.2% and 8.5% of diabetic and control people, respectively (P = 0.97).CONCLUSION We report the absence of any significant genetic variant that could affect the function of RFX6-DNA binding domain in T2D. | Ismail S Mahmoud Ayat Homsi Hamzeh J Al-Ameer Jihad Alzyoud Mais Darras Mohammad Al Shhab Malek Zihlif Ma’mon M Hatmal Walhan Alshaer | 2019 | World Journal of Diabetes2019，10，3： | 0 |
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