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| 1 | Paramyxovirus evasion of innate immunity: Diverse strategies for common targets显示文摘The paramyxoviruses are a family of > 30 viruses that variously infect humans, other mammals and fish to cause diverse outcomes, ranging from asymptomatic to lethal disease, with the zoonotic paramyxoviruses Nipah and Hendra showing up to 70% case-fatality rate in humans. The capacity to evade host immunity is central to viral infection, and paramyxoviruses have evolved multiple strategies to overcome the host interferon(IFN)-mediated innate immune response through the activity of their IFN-antagonist proteins. Although paramyxovirus IFN antagonists generally target common factors of the IFN system, including melanoma differentiation associated factor 5, retinoic acid-inducible gene-I, signal transducers and activators of transcription(STAT)1 and STAT2, and IFN regulatory factor 3, the mechanisms of antagonism show remarkable diversity between different genera and even individual members of the same genus; the reasons for this diversity, however, are not currently understood. Here, we review the IFN antagonism strategies of paramyxoviruses, highlighting mechanistic differences observed between individual species and genera. We also discuss potential sources of this diversity, including biological differences in the host and/or tissue specificity of different paramyxoviruses, and potential effects of experimental approaches that have largely relied on in vitrosystems. Importantly, recent studies using recombinant virus systems and animal infection models are beginning to clarify the importance of certain mechanisms of IFN antagonism to in vivo infections, providing important indications not only of their critical importance to virulence, but also of their potential targeting for new therapeutic/vaccine approaches. | Michelle D Audsley Gregory W Moseley | 2013 | World Journal of Virology2013，2，2： | 2 |
| 2 | Accuratetechnique for complete geometric cone-beam compu-ted tomography systems 显示文摘 | Cho Y Moseley D J Siewerdsen J H | 2005 | Medical Physics2005，32，4： | 1 |
| 3 | Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer显示文摘 | Haudenschild D Moseley T Rose L | 2002 | J Biol Chem2002，277，6： | 1 |
| 4 | Interleukin-17 family and IL-17 receptors显示文摘 | MOSELEY T A HAUDENSCHILD D R ROSE L | 2003 | Cytokine Growth Factor Rev2003，14，2： | 1 |
| 5 | The SUDEP Risk Inventory:Association with postictal generalized EEG suppression显示文摘 | Moseley B D DeGiorgio C M | 2015 | Epilepsy Res2015，117，： | 1 |
| 6 | Compensators for dose and scatter management in cone-beam computed tomography 显示文摘 | GRAHAM S A MOSELEY D J SIEWERDSEN J H | 2007 | Med Phys2007，34，7： | 1 |
| 7 | Accurate technique for complete geometric calibration of cone-beam computed tomography systems显示文摘 | Cho Y B Moseley D J Siewerdsen J H | 2005 | Medical Physics2005，32，4： | 1 |
| 8 | Interleukin-17 family and IL-17 receptors显示文摘 | Moseley T A Haudenschild D R Rose L | 2003 | Cytokine Growth Factor Rev2003，14，2： | 1 |
| 9 | Interleukin17 family and IL-17 receptors显示文摘 | MOSELEY T A HAUDENSCHILD D R ROSE L | | 0，，2： | 1 |
| 10 | The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes显示文摘 | NOZELL S LAVER T MOSELEY D | 2008 | Mol Cell Biol2008，28，21： | 1 |
| 11 | Cancer - related fatigue : the scale of the problem 显示文摘 | Hofman Maarten Ryan Julie L Figueroa - Moseley Colmar D | 2007 | The Oncolo- gist2007，12，1： | 1 |
| 12 | Characteristics of postictal generalized EEG suppression in children显示文摘 | Moseley B D So E Wirrell E C | 2013 | Epilepsy Res2013，106，12： | 1 |
| 13 | Interleukin-17 family and IL-17 receptors显示文摘 | Moseley T A Haudensehild D R Rose L | 2003 | Cytokine & Growth Factor Reviews2003，14，2： | 1 |
| 14 | Spatial consequences of dectromagnetically induced transparency observation of dectromagnetically induced focusing显示文摘 | MOSELEY R R SHEPHEERD S FULTON D J | 1995 | Phys Rev Lett1995，74，： | 1 |
| 15 | Respiration correlated cone-beam computed tomography and 4DCT for evaluating target motion in stereotactic lung radiation therapy 显示文摘 | Purdie TG Moseley D J Bissonnette JP | 2006 | Acta Oncol2006，45，7： | 1 |
| 16 | Dual modes of rabies P-protein association with mierotubules: a novel strategy to suppress the antiviral response 显示文摘 | Moseley G W Lahaye X Roth D M | 2009 | J Cell Sci2009，122，20： | 1 |
| 17 | The stability of mechanical calibration for a kV cone beam computed tomography system integrated with linear accelerator 显示文摘 | SHARPE M B MOSELEY D J PURDIE T G | 2006 | Med Phys2006，33，1： | 1 |
| 18 | Prediction of hemorrhagic transformation following acute stroke role of diffusion- and perfusion?weighted magnetic resonance imaging 显示文摘 | TONG D C ADAMI A MOSELEY M E et a1 | 2001 | Arch Neurol2001，58，4： | 1 |
| 19 | Intraoperative cone-beam CT for guidance of head and neck surgery:Assessment of dose and image quality using a C-arm prototype显示文摘 | Daly M J Siewerdsen J H Moseley D J | 2006 | Med Phys2006，33，37： | 1 |
| 20 | Prognostic significance of admission troponin T concentration in patients with myocardial infarction显示文摘 | Stubbs P Collinson P Moseley D | 1994 | Circulation1994，94，： | 1 |
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