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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Established human papillomavirus type 16 expressing tumors are effective ly eradicated following vaccination with long peptides 显示文摘 | Zwaveling S Ferreira Mota S C Nouta J | 2002 | J Immunol2002，169，1： | 1 |
| 3 | What is the role of inspiratory muscle training in the treatment of chronic obstructive pulmonary disease? 显示文摘 | Mota Casals S | 2005 | Arch Bronconeunol2005，41，： | 1 |
| 4 | Biodegradation of colorants in refinery effluents : potential use of the fungus Phanerochaete chrysosporium显示文摘 | Guimaraes C Bento L S M Mota M | 1999 | International Sugar Journal1999，101，： | 1 |
| 5 | C02 laser surgery in the treatment of glottic cancer显示文摘 | Mota G Esposito E Motta S | 2005 | Head Neck2005，27，7： | 1 |
| 6 | Enzymatic probe sonication as a tool for solid-liquid extraction for total se-lenium determination by electrothermal-atomic absorption spectrometry 显示文摘 | Vale G Pereira S Mota A | 2007 | Talanta2007，74，2： | 1 |
| 7 | Ab initiocalculations for a hypothetical material:silicon nanotubes显示文摘 | FAGAN S B BAIERLE R J MOTA R | 2000 | Phys Rev:B2000，61，15： | 1 |
| 8 | A membrane - permea- ble radical scavenger reduces the organ injury in hemorrhagic shock 显示文摘 | Mota - Filipe H Mcbonald MC Cuzzocrea S | 1999 | Shock1999，12，3： | 1 |
| 9 | Overt immune dysfunction after Cushing's syndrome remission:a consecutive case series and review of the literature显示文摘 | da Mota F Murray C Ezzat S | | 0，，10： | 1 |
| 10 | Antitumor efficacy of wild-type p53-specific CD4 ( + ) T-helper ceils 显示文摘 | Zwaveling S Vierboom MP Ferreira Mota SC | 2002 | Cancer Res2002，62，21： | 1 |
| 11 | The antigen-presenting envi- ronment in normal and human papillomavirus (HPV)-related prema- lignant cervical epithelium显示文摘 | Mota F Rayment N Chong S | 1999 | Clin Exp Immunol1999，116，1： | 1 |
| 12 | Resistance and cross-resistance to neonicotinoid insecticides and spinosad in the Colorado potato beetle,Leptinotarsa decemlineata (Say) (Coleoptera:Chrysomelidae)显示文摘 | Mota S D Hollingworth R M Grafius E J | 2006 | Pest Manag Sci2006，62，： | 1 |
| 13 | Mitochondrial bioenergetics of testicular cells from the domestic cat (fells catus) - a model for endangered species 显示文摘 | Mota PC Amaral S Martins L | 2009 | Reprod Toxicol2009，11，： | 1 |
| 14 | Reductive decolorization of the azo dye RR2 in the absence and presence of redox mediator and the electrons acceptor nitrate显示文摘 | BRAIJNA C H C MOTA S DOS SANTOS A B | 2009 | En genharia Sanitaria E Ambiental2009，14，2： | 1 |
| 15 | Clinic outcomes of expiratory muscle training in severe COPD patients显示文摘 | Mota S Guell R Barreiro E | 2007 | Respir Med2007，101，3： | 1 |
| 16 | Optimisation of extraction procedures for analysis of benzoic and sorbic acids in foodstuffs显示文摘 | Mota F J M Cunha S C Beatriz M | 2003 | Food Chemistry2003，82，： | 1 |
| 17 | Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb显示文摘 | Scotto-Lomassese S Nissant A Mota T | 2011 | J Neurosci2011，31，6： | 1 |
| 18 | Finite-element simulation of firearm injury to the human cranium 显示文摘 | A Mota W S Klug M Ortiz A Pandolfi | 2003 | Computational Mechanics2003，31，： | 1 |
| 19 | The antigen-presenting environment in normal and human papillomavirus (HPV)-related premalignant cervical epithelium显示文摘 | Mota F Rayment N Chong S | 1999 | Clin Exp Immunol1999，116，： | 1 |
| 20 | Physical Activity,Obesity Status,and Blood Pressure in Preschool Children显示文摘 | Vale S Trost S G Rego C Abreu S Mota J | 2015 | Journal of pediatrics2015，167，1： | 1 |
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