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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Cadmium toxicity affects photosynthesis and plant growth at different levels 显示文摘 | Dias blC Monteiro C Moutinho - Pereira J | 2013 | Aeta Physiologiae Plantarum2013，35，4： | 1 |
| 3 | A backstepping controller for path-tracking of an underactuated autonomous airship显示文摘 | Azinheira J R Moutinho A Paiva E C | 2009 | Int J Robust and Nonlinear Control2009，19，4： | 1 |
| 4 | Brand relationships through brand reputation and brand tribalism显示文摘 | Veloutsou C Moutinho L | 2009 | Journal of Business Research2009，62，3： | 1 |
| 5 | Dynamic epigenetic reg- ulation of the micmRNA-200 family mediates epithelial and mes- enchymal transitions in human tumorigenesis 显示文摘 | Davalos V Moutinho C Villanueva A | 2012 | Oncogene2012，31，16： | 1 |
| 6 | Direct evi- dence of a buried homojunetion in Cu (In,Ga)Se2 solar cells 显示文摘 | JIANG C S HASOON F S MOUTINHO H R | 2003 | Appl Phys Lett2003，82，： | 1 |
| 7 | Continuous dynamic monitoring of a lively footbridge for serviceability assessment and damage detection 显示文摘 | Hu W H Moutinho C Caetano E | 2012 | Mechanical Systems and Signal Processing2012，33，： | 1 |
| 8 | An Alternative Methodology for Designing Tuned Mass Dampers to Reduce Seismic Vibrations in Building Structures显示文摘 | Moutinho C | 2012 | Earthquake Engineering & Structural Dynamics2012，4，14： | 1 |
| 9 | BRAF,KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in eolorectal carcinogenesis 显示文摘 | Velho S Moutinho C Cirnes L | 2008 | BMC Cancer2008，8，： | 1 |
| 10 | Epidermal growth factor receptor structural alterations in gastric cancer显示文摘 | MOUTINHO C MATEUS AR MILANEZI F | 2008 | BMC Cancer2008，8，： | 1 |
| 11 | Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase I1 study for metastatic colorectal cancer 显示文摘 | Amatu A Sartore-Bianchi A Moutinho C | 2013 | Clin Cancer Res2013，19，8： | 1 |
| 12 | Brand relationships through brand reputation and brand tribalism 显示文摘 | Veloutsou C and Moutinho L | 2009 | Journal of Business Research2009，62，3： | 1 |
| 13 | Promoter CpG island hypermethylation of the DNA repair enzyme mgmt predicts clinical response to dacarbazine in a phase ii study for metastatic colorectal cancer 显示文摘 | Amatu A Sartore-Bianchi A Moutinho C | 2013 | Clin Cancer Res2013，19，8： | 1 |
| 14 | BRAF,KRAS and PIK3CA mutations in colorectal serrated polyps and cancer:primary or secondary genetic events in colorectal carcinogenesis?显示文摘 | Velho S Moutinho C Cirnes L | 2008 | BMC Cancer2008，9，8： | 1 |
| 15 | Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis显示文摘 | Davalos V Moutinho C Villanueva A | 2012 | Oncogene2012，31，16： | 1 |
| 16 | Brand relationships through brand reputation and brand tribalism 显示文摘 | Veloutsou C and Moutinho L | 2009 | Journal of Business Research2009，62，3： | 1 |
| 17 | A genetic defect in export- in-5 traps precursor microRNAs in the nucleus of cancer cells 显示文摘 | Melo SA Moutinho C Ropero S | 2010 | Cancer Cell2010，18，4： | 1 |
| 18 | Liposomes as a model for the bi- ological membrane studieson daunorubicin hilayer interaction 显示文摘 | Matos C Moutinho C Lobao P | 2012 | J Membr Biol2012，245，2： | 1 |
| 19 | KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression显示文摘 | Oliveira C Velho S Moutinho C | 2007 | Oncogene2007，26，1： | 1 |
| 20 | Flavour development via lipolysis of milkfats: changes in free fatty acid pool 显示文摘 | REGADO M A CRISTOYAO B M MOUTINHO C G | 2007 | Int J Food Sei Teehnol2007，42，： | 1 |
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