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| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | G0E: the first core Earth explorer of ESA's Earth observation programme 显示文摘 | Muzi D Allasio A | 2004 | Acta Astronautica2004，54，2： | 1 |
| 3 | Multifractal Returns and Hierarchical Portfolio Theory显示文摘 | MUZY J F SORNETTE D DELOUR J | 2001 | Quantitative Finance2001，1，1： | 1 |
| 4 | Polaronic Effects in Mixed Excitons: Theory and Resonant Raman Spectroscopy 显示文摘 | ANDREA A D MUZI R | 1995 | Solid State Commun1995，95，7： | 1 |
| 5 | Molecular aspects of gefitinib antiproliferative and prok-apoptotic effects in PTEN-positire and PTEN-negative prostate cancer cell lines 显示文摘 | Festuccia C Muzi P MiUimaggi D | 2005 | Endocr Relat Cancer2005，12，4： | 1 |
| 6 | Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cel s in vitro显示文摘 | Festuccia C Muzi P Gravina GL Millimaggi D Speca S Dolo V | 2007 | Int J Oncol2007，30，1： | 1 |
| 7 | Does propofol really preservebaroreflex funxtion in humans显示文摘 | Ebert T Muzi M Goff D | 1992 | Anesthesiology1992，77，： | 1 |
| 8 | 'Direct' causal cascade in the stock market 显示文摘 | Arneodo A Muzy J F Sornette D | 1998 | The European Physical Journal B1998，2，2： | 1 |
| 9 | GOCE:the first core earth explorer of ESA's earth observation programme显示文摘 | Muzi D Allusio A | 2004 | Acta Astrouautica2004，54，2： | 1 |
| 10 | Induction of anesthesia and tracheal intu bation with sevoflurane inadults显示文摘 | MUZI M D ROBINSON M D | 1996 | Anesthesiology1996，85，： | 1 |
| 11 | Molecular aspects of gefitinib antipro liferative and pm-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell 显示文摘 | Festuccia C Muzi P Millimaggi D | 2005 | Endocr Relat Cancer2005，12，： | 1 |
| 12 | Nucleotide composition effects on the long-range correlations in human genes显示文摘 | A. Arnéodo Y. d’Aubenton-Carafa B. Audit E. Bacry J.F. Muzy C. Thermes | 1998 | The European Physical Journal B1998，，2： | 1 |
| 13 | 'Direct' Causal Cascade in the Stockmarket显示文摘 | ARNEODO A MUZY J F SORNETTE D | 1998 | European Physieal Journal B1998，2，2： | 1 |
| 14 | GOCE: the first core Earth explorer of ESA's Earth observation pro- gramme 显示文摘 | MUZI D ALLASIO A | 2004 | Acta Astronautica2004，54，3： | 1 |
| 15 | Carboxytherapy and Platelet Rich Plasma: A New Therapy for Trigonitis, Abacterial and Interstitial Cystitis显示文摘 | Muzi Fabrizio Delicato Giampaolo D'Andria Daniele Baffigo Giulio Tartaglia Edoardo Tati Eleonora Corvese Francesco Signore Stefano Perla Alessandro Montagna Giuseppe Tati Gaetano | 2015 | Journal of Pharmacy and Pharmacology2015，3，9： | 0 |
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