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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | A comparison of discharge immunosuppressive drug regimens in primary eadaverie kidney transplan-tation显示文摘 | Myron KH Maghirang J | 2003 | Transplantation2003，76，3： | 1 |
| 3 | Self-tuning PID Controller Uses Pattern Recognition Approach显示文摘 | Kraus T W Myron T J | 1984 | Control Engineering1984，31，6： | 1 |
| 4 | Clinical indications for plasma protein assays:transthyretin (prealbumin)in inflammation and malnutrition 显示文摘 | MYRON JOHNSON A MERLINI G SHELDON J | 2007 | Clin Chem Lab Med2007，45，3： | 1 |
| 5 | Serum γ- Glutamyhransferase was differently associated with microalbuminuria by status of hyperten- sion or diabetes : the coronary artery risk development in young adults (CARDIA) study显示文摘 | Lee DH J R David G Myron | 2005 | Clin Chem2005，51，： | 1 |
| 6 | The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study显示文摘 | Drolet Mélanie Brisson Marc Schmader Kenneth E Levin Myron J Johnson Robert Oxman Michael N Patrick David Blanchette Caty Mansi James A | 2010 | Canadian Medical Association. Journal2010，，： | 1 |
| 7 | Self-tuning PID control-an expert system approach, automatic control in petroleum,petrochemical and desalination industries显示文摘 | MYRON T J | 1986 | Proceedings of the IFAC Workshop1986，15，8： | 1 |
| 8 | An investigation of factors affecting how engineers and scientists seek information显示文摘 | CLAIRE J ANDERSON MYRON GLASSMAN R BRUCE MCAFEE | 2001 | Journal of En- gineering and Technology Management2001，18，2： | 1 |
| 9 | Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults 显示文摘 | Anthony R H Kim B Myron J L | 1994 | Vir Immun1994，7，： | 1 |
| 10 | Influences of calcium a- vailability and tree species on Ca isotope fractionation in soil and vegetation显示文摘 | Blair D P Thomas D B Myron J M | 2008 | Biogeochemistry2008，88，： | 1 |
| 11 | The problem of immunity inoculation of Hepatitis B in neonatal infant and children显示文摘 | Myron J T | 1989 | Am J Med1989，87，3： | 1 |
| 12 | Financial Gain from Conglomerate Merger显示文摘 | Gordon Myron J Joseph Yagil | | 0，，06： | 1 |
| 13 | Effect of temperature on the biology of Acyrthosiphon gossypii Mordvilko ( Homoptera: Aphidi- dae) on cotton显示文摘 | Gao G J Lynda E P Myron P | 2013 | Journal Pest Science2013，86，： | 1 |
| 14 | Self-tuing PID controller uses pattern recognition approach显示文摘 | Myron T J | 1984 | Control Engineering1984，31，6： | 1 |
| 15 | Isotopic evidence for determining the sources of dissolved or- ganic sulfur in a forested catchment显示文摘 | Kang Phil-Goo Mitchell Myron J Mayer Bernhard | 2014 | Environ Sci Teeh- nol2014，48，11： | 1 |
| 16 | 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host显示文摘 | LORRY G RUBIN MYRON J | 2014 | Clin Infect Dis2014，58，3： | 1 |
| 17 | Guidance and relative navigation for autonomous rendezvous in a circular orbit显示文摘 | HABLANI B HARI TAPPER L MYRON DANA-BASHIAN J DAVID | 2002 | Journal of Guidance Control and Dynamics2002，25，3： | 1 |
| 18 | Guidance and navigation for autonomous rendezvous in a circular orbit显示文摘 | Haft B Hablani Myron L Tapper David J dana-bashian | 2002 | Journal of Guidance Control and Dynamics2002，25，3： | 1 |
| 19 | Down-regulation of cinnamoyl-CoA reductase induces significant changes of lignin profiles in transgenic tobacco plants显示文摘 | Piquemal J Lapierre C Myron K | 1998 | Plant J1998，13，： | 1 |
| 20 | Clinical indications for plasma protein assays:transthy retin (prealbumin) in inflammation and malnutrition显示文摘 | Myron Johnson A Merlini G Sheldon J | | 0，，03： | 1 |
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