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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | Icariin, a flavonoid fr- om the herb Epimedium enhances the osteogenic differen- tiation of rat primary bone marrow stromal cells显示文摘 | Chen KM Ge BF Ma HP | 2005 | Pharmazie2005，60，12： | 1 |
| 3 | Pharmacology of curcuma longa显示文摘 | Ammon HP Wahl MA | 1991 | Planta Med1991，57，： | 1 |
| 4 | Neonatal meningitis: What is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebro- spinal fluid parameters? 显示文摘 | Garges HP Moody MA Cotten CM Smith PB Tiffany KF Len- festey R | 2006 | J Pediatr2006，117，4： | 1 |
| 5 | Mechanical initiation of intervertebral disc degeneration显示文摘 | Adams MA Briaan JC Morrison HP | | 0，，： | 1 |
| 6 | Effect of aqueous extract of azadirachta indica leaves on hepatotoxicity induced by anti -tubercular drugs in rats显示文摘 | Kale BP Kothekar MA Tayade HP | 2003 | Indian J Pharmaco12003，35，： | 1 |
| 7 | Ultraviolet A/riboflavin corneal cross-linking for infections keratitis associated with corneal melts显示文摘 | Iseli HP Thiel MA Hafezi F | 2008 | Cornea2008，27，5： | 1 |
| 8 | Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro显示文摘 | Ming LG Zhou J Cheng GZ Ma HP Chen KM | 2011 | Pharmacology2011，88，12： | 1 |
| 9 | In vivo amyloid imaging inautopsy-confirmed Parkinson disease with dementia显示文摘 | Burack MA Hartlein J Flores HP | 2010 | Neurology2010，74，1： | 1 |
| 10 | Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and eerebrospinal fluid parameter? 显示文摘 | Garges HP Moody MA Cotten CM | 2006 | Pediatrics2006，117，4： | 1 |
| 11 | Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats 显示文摘 | Mohan-Kumari HP Dhale MA Akhilender Naidu K | 2011 | Cell Biochem Funct2011，29，7： | 1 |
| 12 | Long-term follow-up of functional outcome in patients with a cloacal malformation: a systematic review显示文摘 | Versteegh HP van Rooij IA Levitt MA | 2013 | J Pediatr Surg2013，48，11： | 1 |
| 13 | Mechanical initiation of intervertebral discdegeneration 显示文摘 | Adams MA Freeman B J Morrison HP | 2000 | Spine ( Phila Pa 1976 )2000，25，： | 1 |
| 14 | Bounds on the local bases of primitive non-powerful minimally strong signed digraphs 显示文摘 | Ma HP | 2009 | Linear Algebra Appl2009，430，： | 1 |
| 15 | Digital breast tomosynthesis: observer performance of clustered micro-calcification detection on breast phantom images ac- quired with an experimental system using variable scan angles, angular increments, and number of projection views显示文摘 | Ehan HP Goodsitt MM Helvie MA | 2014 | Radiology2014，273，3： | 1 |
| 16 | Clinical guideline : management of gastroparesis显示文摘 | Camilleri M Parkman HP Shaft MA | 2013 | Am J Gastroenterol2013，108，1： | 1 |
| 17 | Bounds on the local bases of primitive non-powerful, minimally strong signed digraphs 显示文摘 | Ma HP | 2009 | Linear Algebra Appl2009，430，： | 1 |
| 18 | Mechanical initiation of intervertebral disc degeneration显示文摘 | Adams MA Freeman BJ Morrison HP | 2000 | Spine2000，25，13： | 1 |
| 19 | Responses of normal cells to ionizing radiation显示文摘 | Rodemann HP Blaese MA | 2007 | Semin Radiat Oncol2007，17，2： | 1 |
| 20 | Bounds on the local bases of primitive, non-powerful, minimally strong signed digraphs 显示文摘 | Ma HP | 2009 | Linear Algebra Appl2009，430，： | 1 |
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