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| 1 | Long noncoding RNAs:a missing link in osteoporosis显示文摘Osteoporosis is a systemic disease that results in loss of bone density and increased fracture risk,particularly in the vertebrae and the hip.This condition and associated morbidity and mortality increase with population ageing.Long noncoding(lnc)RNAs are transcripts longer than 200 nucleotides that are not translated into proteins,but play important regulatory roles in transcriptional and post-transcriptional regulation.Their contribution to disease onset and development is increasingly recognized.Herein,we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic tools.Firstly,current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication,fragility fractures,is reviewed.We analyze evidence of their roles in osteogenesis,osteoclastogenesis,and bone fracture healing events from human and animal model studies.Secondly,the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for diagnosis.Finally,we conclude debating the possibilities,persisting difficulties,and future prospects of using lncRNAs in the treatment of osteoporosis. | Andreia Machado Silva Sara Reis Moura JoseHenrique Teixeira Mario Adolfo Barbosa Susana Gomes Santos Maria Ines Almeida | 2019 | Bone Research2019，7，1： | 13 |
| 2 | Prenatal diagnosis of a partial trisomy 13q (ql4→qter) : phenotype, cytogenetics and molecular characterization by spectral karyotyping and array comparative genomic hybridization显示文摘 | Machado IN Heinrich JK Campanhol C | 2010 | Genet Mol Res2010，9，： | 1 |
| 3 | Prenatal diagno- sis of a partial trisomy 13q (q14→qter) : phenotype, cytogeneties and molecular characterization by spectral karyotyping and ar- ray comparative genomic hybridization 显示文摘 | Machado IN Heinrich JK Campanhol C | 2010 | Genet Mol Res2010，9，1： | 1 |
| 4 | Prenatal genomic profiling of abdominal wall defects through comparative genomic hybridization:perspectives for a new diagnostic tool显示文摘 | Machado IN Vivas L | 2007 | Fetal Diagn Ther2007，22，5： | 1 |
| 5 | Headache as the sole presentation of cerebral venous thrombosis:a prospective study显示文摘 | Timóteo Inácio N Machado S | | 0，，： | 1 |
| 6 | Bacterial community profiles of endodontic abscesses from Brazilian and USA subjects as compared by denaturing gradient gel electrophoresis analysis显示文摘 | Machado de Oliveira JC Siqueira JF Jr R6qas IN | 2007 | Oral Microbiol lmnmno12007，22，1： | 1 |
| 7 | 将5-羟色胺-去甲肾上腺素再摄取抑制剂引入巴西国家药品目录的经济学影响——成本-效果分析和预算影响分析显示文摘目的:从巴西卫生部的角度出发,评价三类治疗重性抑郁症(major depressive disorder, MDD)药物在6个月治疗期间的成本-效果,以及将5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRIs)引入巴西国家药品目录对预算的影响。方法:本研究采用《巴西医学会抑郁症临床治疗指南》推荐的决策树模型。临床数据来自一项已发表的Meta分析。患者包括年龄18岁以上患有中重度MDD[汉密尔顿抑郁量表(HAMD)分值≥15,或者蒙哥马利抑郁量表(MADRS)分值≥18]的成年MDD患者。MDD根据第三版和第四版精神障碍诊断及统计手册(DSM-Ⅲ/Ⅳ)进行诊断,患者无共病或合并药物治疗,只接受≥6周的SNRIs、选择性5-羟色胺再摄取抑制剂(SSRIs)和(或)三环类抗抑郁药(TCAs)治疗。临床产出采用缓解率(HAMD≤7或者MADRS≤12)。分析中包括直接成本(药品成本、医生访视成本和住院成本)。药品成本来自2006年巴西国家药品价格表,住院成本和医生成本来自2006年医疗保健系统数据库。成本数据用巴西货币单位雷亚尔($Brz)2006年价格(1雷亚尔=0.47美元)表示。利用单因素敏感性分析和Monte Carlo敏感性分析检验模型的稳健性。结果:SNRIs组治疗的平均期望成本为4848雷亚尔,SSRIs组为5466雷亚尔,TCAs组为5046雷亚尔。总成功率(包括决策树中所有分支一线和二线治疗的成功率)分别是SNRIs组78.1%,SSRIs组74.0%,TCAs组76.4%。每成功治疗一例的成本分别是SNRIs组6209雷亚尔,SSRIs组7385雷亚尔和TCAs组6602雷亚尔。在增量成本-效果分析中,SNRIs组具有绝对优势。Monte Carlo分析证实了三类抗抑郁药物成本-效果比值排序的相对位置,但是仍然有很大的不确定性。将SNRIs药物引入到药品目录能够使总预算平均减少1%,成本节约的概率是52%。结论:在巴西,给MDD病人处方SNRIs药物,似乎比处方SSRIs和TCAs药物更具有成本-效果优势。但是,将SNRIs药物引入国家药品目录只会比目录中现有的SSRIs和TCAs药物节省很少预算。因此,我们认为将SNRIs药物引入巴西国家药品目录的结果为'成本中立',因为我们没有观察到很大的节省或者增加支出的可能性。 | M árcio Machado Michael Iskedjian Inés A.Ruiz Thomas R.Einarson 李海涛 李洪超 | 2009 | 中国药物经济学2009，，3： | 1 |
| 8 | Simulating trends in soil organic carbon of an Acrisol under no-tillage and disc-plow systems using the Century model显示文摘 | Luiz Fernando Carvalho Leite Eduardo de Sá Mendon?a Pedro Luiz Oliveirade de Almeida Machado Elp??dio Inácio Fernandes Filho Júlio César Lima Neves | 2003 | Geoderma2003，，3： | 1 |
| 9 | Bacterial community profiles of endodontic ab- scesses from Brazilian and USA subjects as com- pared by denaturing gradient gel electrophoresis analysis显示文摘 | Machado de Oliveira JC Siqueira JF Jr R6?as IN | 2007 | Oral Microbiol Immunol2007，22，1： | 1 |
| 10 | Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery显示文摘 | Fernanda Boesing Emilia Addison Machado Moreira Danilo Wilhelm-Filho Silvana Virgínia Gagliotti Vigil Eduardo Bennedetti Parizottto Déborah Bunn Inácio Guilherme Vannucchi Portari Erasmo Benício Santos Moraes Trindade Alceu Afonso Jord?o-Júnior Tania Silv | 2010 | Obesity Surgery2010，，9： | 1 |
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