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| 1 | Matrix metalloproteinase-9:A deleterious link between hepatic ischemia-reperfusion and colorectal cancer显示文摘Despite the advent of improved surgical techniques and the development of cytotoxic chemotherapeutic agents useful for the treatment of colorectal cancer,the primary clinical challenge remains that of preventing and combating metastatic spread.Surgical resection is the best treatment for colorectal metastases isolated to the liver.However,in rodent models,the hepatic ischemia-reperfusion(I/R) applied during the surgery accelerates the outgrowth of implanted tumors.Among the adverse effects of I/R on cellular function,several studies have demonstrated an over expression of the matrix metalloproteinase-9(MMP-9) in the ischemic liver.Since several studies showed high local levels of expression and activity of this proteolytic enzyme in the primary colorectal adenocarcinoma,the role of MMP-9 might be considered as a potential common mediator,favoring both growth of local tumor and the dissemination of colorectal carcinoma metastases. | Sébastien Lenglet Franois Mach Fabrizio Montecucco | 2012 | World Journal of Gastroenterology2012，18，48： | 6 |
| 2 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 3 | Statin Treatment Is Associated with Reduction in Serum Levels of Receptor Activator of NF- κ B Ligand and Neutrophil Activation in Patients with Severe Carotid Stenosis显示文摘 | Sébastien Lenglet Alessandra Quercioli Mathias Fabre Katia Galan Graziano Pelli Alessio Nencioni Inga Bauer Aldo Pende Magaly Python Maria Bertolotto Giovanni Spinella Bianca Pane Domenico Palombo Franco Dallegri Fran?ois Mach Nicolas Vuilleumier Fabrizio | 2014 | Mediators of Inflammation2014，，： | 2 |
| 4 | Role of four major cellulases in triggering of cellulase gene expression by cellulose in Trichoderma reesei 显示文摘 | Seiboth B Hakola S Mach R L | 1997 | J Bacteriol1997，179，17： | 1 |
| 5 | Insulin resist- ance: a proinflammatory state mediated by lipid-in- duced signaling dysfunction and involved in atheroscle- rotic plaque instability显示文摘 | Montecucco F Steffens S Mach F | 2008 | Mediators Inflamm2008，2008，： | 1 |
| 6 | Role of four major cellulases in triggering of cellulase gene expression by cellulose in Trichoderma reesei显示文摘 | Seiboth B Hakola S Mach R L | 1997 | Journal of Bacteriology1997，179，17： | 1 |
| 7 | Role of four major cellulases in triggering of ceUulase gene expression by cellulose in Trichoderma reesei 显示文摘 | SE1BOTH B HAKOLA S MACH R L | 1997 | J Baeteriol1997，179，17： | 1 |
| 8 | Inflammation and atherosclerosis显示文摘 | Steffens S Mach F | 2004 | Herz2004，29，8： | 1 |
| 9 | Monolithically integrated,flexible display of polymer-dispersed liquid crystal driven by rubber-stamped organic thin-film transistors显示文摘 | MACH P RODRIGUEZ S J NORTRUP R | | 0，，23： | 1 |
| 10 | The stromal cell- derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques显示文摘 | Abi-Younes S Sauty A Mach F | 2000 | Circulation2000，86，2： | 1 |
| 11 | The differential effect of team members' trust on team performance: The me- diation role of team cohesion显示文摘 | Mach M Dolan S Tzafrir S | 2010 | Journal of Occupa- tional and Organizational Psychology2010，83，3： | 1 |
| 12 | Ca2+-calmodulin antagonists interfere with xylanase formation andsecretion in Trichoderma reesei显示文摘 | MACH R L ZEILINGER S KRISTUFEK D | 1998 | Biochimica et BiophysicaActa1998，1403，： | 1 |
| 13 | The specific role of chemo- kines in atherosclerosis 显示文摘 | Braunersreuther V Mach F Steffens S | 2007 | Thromb Haemost2007，97，5： | 1 |
| 14 | Regulation of gene expressionin industrial fungi:Trichoderma显示文摘 | MACH R L ZEILINGER S | 2003 | Applied MicrobiologicalBiotechnology2003，60，： | 1 |
| 15 | Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand显示文摘 | Mach N Gillessen S Wilson B | 2000 | Cancer Res2000，60，： | 1 |
| 16 | Role of fourmajor cellulases in triggering of cellulose gene expression bycellulose in Trichoderma reesei显示文摘 | SEIBOTH B HAKOLA S MACH R L | 1997 | Journal of Bacteriology1997，179，17： | 1 |
| 17 | Regulation of gene expression in industrial fungi:Trichoderma显示文摘 | Mach R L Zeilinger S | | 0，，05： | 1 |
| 18 | Drug insight :Immunomodulatory effects of statinspotential benefits for renal patients? 显示文摘 | Steffens S Mach F | 2006 | Nat Clin Pract Nephrol2006，2，7： | 1 |
| 19 | Cannabinoid receptors in atherosclerosis 显示文摘 | Steffens S Mach F | 2006 | Curr Opin Lipidol2006，17，5： | 1 |
| 20 | Wire bonding at higher ultrasonic fiequencies: reliability and process implications 显示文摘 | H K Charles Jr K J Mach S J Lehtonen | 2003 | Microelectronics Reliability2003，43，2003： | 1 |
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