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| 1 | Preliminary phytochemical analysis,antibacterial,antifungal and anticandidal activities of successive extracts of Crossandra infundibuliformis显示文摘Objective:To investigate the phytochemical,antibacterial,antifungal and anticandidal activity of successive extracts of Crossandra infundibuliformis(Acanthaceae) leaves.Methods:Preliminary screening on the presence of alkaloids,saponins,phytosterols,phenolic compounds,flavanoids, tannins,carbohydrates,terpenoids,oils and fats were carried out by phytochemical analysis.The antibacterial,antifungal and anticandidal activities were done by agar well diffusion technique. Results:The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0μg/mL.In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250μg/mL.Conclusions:These findings demonstrate that the leaf extracts of C.infimdibuliformis presents excellent antimicrobial activities and thus have great potential as a source for natural health care products. | Madhumitha G A.Mary Saral | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 12 |
| 2 | Hepatoprotective potential of petroleum ether leaf extract of Crossandra infundibuliformis on CCl_4 induced liver toxicity in albino mice显示文摘Objective:To analyze the hepatoprotective effect of the Crossandra infundibuliformis.Methods: Hepatotoxicity was induced by carbon tetrachloride.Petroleum ether extract of dried leaves was administrated to mice for 7 days.The hepatoprotective effect of petroleum ether extract was evaluated by the assay of liver function biochemical parameters.Results:The result clearly indicates that petroleum ether extract showed significant hepatoprotection when compared with standard Silumarin.Conclusions:The petroleum ether extract of the leaves of Crossandra infundibuliformis possess significant acute hepatoprotective activity.Thus further investigation on this species would bring a promising drug for liver disorders. | G Madhumitha A Mary Saral B Senthilkumar A Sivaraj | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 2 |
| 3 | A cAMP and CREB-mediated feed-forward mechanism regulates GSK3β in polycystic kidney disease显示文摘Glycogen synthase kinase 3β(GSK3β),a serine/threonine protein kinase,is commonly known to be regulated at the level of its activity.However,in some diseases including polycystic kidney disease(PKD),GSK3βexpression is increased and plays a pathophysiological role.The current studies aimed to determine the mechanism for the increased GSK3βexpression in PKD and its significance to disease progression.In mouse models of PKD,increases in renal GSK3βcorresponded with increases in renal cAMP levels and disease progression.In vivo and in vitro studies revealed that GSK3βis a cAMP-responsive gene,and elevated cAMP levels,as seen in PKD,can increase GSK3βexpression.In normal mice,vasopressin signaling induced by water deprivation increased GSK3βexpression,which decreased following rehydration.Examination of the GSK3βpromoter revealed five potential binding sites for the transcription factor,cAMP response element binding protein(CREB).CREB was found to bind to GSK3βpromoter and essential for cAMP-mediated regulation of GSK3β.Importantly,this regulation was demonstrated to be part of a feedforward loop in which cAMP through CREB regulates GSK3βexpression,and GSK3βin turn positively regulates cAMP generation.GSK3βor CREB inhibition reduced transepithelial fluid secretion and cyst expansion in vitro.Thus,disruption at any point of this destructive cycle may be therapeutically useful to reduce cyst expansion and preserve renal function in PKD. | Vijayakumar R.Kakade Shixin Tao Madhumitha Rajagopal Xia Zhou Xiaogang Li Alan S.L.Yu James P.Calvet Pankaj Pandey Reena Rao | 2016 | Journal of Molecular Cell Biology2016，8，6： | 1 |
| 4 | Increased Th1and suppressed Th2serum cytokine levels in subjects with diabetic coronary artery disease显示文摘 | Madhumitha H Mohan V Deepa M | 2014 | Cardiovasc Diabetol2014，，13： | 1 |
| 5 | Efficient phyto-synthesis and structural characterization of rutile TiO 2 nanoparticles using Annona squamosa peel extract显示文摘 | Selvaraj Mohana Roopan A. Bharathi A. Prabhakarn A. Abdul Rahuman K. Velayutham G. Rajakumar R.D. Padmaja Mohan Lekshmi G. Madhumitha | 2012 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2012，，： | 1 |
| 6 | Effectiveness of a community-based intervention for people with schizophrenia and their caregivers in India (COPSI): a randomised controlled trial显示文摘 | Sudipto Chatterjee Smita Naik Sujit John Hamid Dabholkar Madhumitha Balaji Mirja Koschorke Mathew Varghese Rangaswamy Thara Helen A Weiss Paul Williams Paul McCrone Vikram Patel Graham Thornicroft | 2014 | The Lancet2014，，： | 1 |
| 7 | Acaricidal, insecticidal, and larvicidal efficacy of fruit peel aqueous extract of Annona squamosa and its compounds against blood-feeding parasites显示文摘 | Gunabalan Madhumitha Govindasamy Rajakumar Selvaraj Mohana Roopan Abdul Abdul Rahuman Kanagaraj Mohana Priya Antoneyraj Mary Saral Fazlur Rahman Nawaz Khan Venkatesh Gopiesh Khanna Kannaiyaram Velayutham Chidambaram Jayaseelan Chinnaperumal Kamaraj Gandhi | 2012 | Parasitology Research2012，，5： | 1 |
| 8 | Free radical scavenging and reducing power of Lawsonia inermis L.seeds显示文摘Objective:To determine the antioxidant activity,total phenolic and flavonoid content of Petroleum ether extract(PE),Dichloromethane extract(DCM),Ethanol extract(ET) and aqueous extract(AQ) of henna seeds.Methods:Total antioxidant assay(phosphomolybenum method), DPPH radical scavenging assay,reducing power assay and lipid peroxidation inhibition assay were used to ascertain the potential of seeds as an antioxidant.Results:In all the assays carried out ET showed a greater potential to scavenge DPPH radical,reduce MO(Ⅳ) to MO(Ⅴ) complex and Fe(Ⅲ) to Fe(Ⅱ) and to inhibit lipid peroxidation.The IC50 of ET was far greater than that of the standard,ascorbic acid(AS) in the lipid peroxidation assay.The activity of AQ was lesser when compared with that of ET but greater than PE and DCM.The amount of phenolics and flavonoids were present in higher amounts in ET followed by AQ.Trace amounts of phenolics were detected in PE and DCM,but the amount of flavonoids were below the detection level.The study showed that the antioxidant activity and the concentrations of phenolics and flavonoids are proportionate to each other.Conclusions:Ethanolic extract of henna seeds are efficient antioxidants,which can be utilized for further isolation of active compounds and pharmaceutical applications. | Philip Jacob P Madhumitha G Mary Saral A | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 1 |
| 9 | 都市绿意 Badari住宅显示文摘Badri住宅位于印度班加罗尔,是一处典型的位于紧凑型城市地块上的房屋,建筑面积为511 m2。业主希望设计师可以将住宅分为两种空间,一部分为私人空间,另一部分用于与家人朋友日常交流,以此鼓励互动和情感融合。最终的设计方案将建筑内外的设计抽象并概念化为一系列寻求'愉悦感'的情节与元素。有着双倍层高的二层起居室空间是整个建筑的灵魂,它将客厅、餐厅、厨房、祈祷室以及室外平台串联成一个整体。同时其内部自带的阳台,更进一步赋予这个空间以盎然生机。流动的空间在满足了个人需求的同时,也营造了舒适而温馨的公共功能区域,为家庭提供了互动空间。在该空间中,设计师不拘一格地使用装饰材料,并加入丰富的色彩和肌理,令空间充满温暖和喜悦。 | 小麦(编译) 无 Smaran Mallesh Narendra Pirgal Vikram Rajashekar Madhumitha Ramesh Nirali Ashra Shamanth Patil(摄影) | 2020 | 室内设计与装修2020，，7： | 0 |
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