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| 1 | CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus显示文摘Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However,the mechanism by which CypA regulates M1 ubiquitination remains unknown. In this study, we reported that E3 ubiquitin ligase AIP4 promoted K48-linked ubiquitination of M1 at K102 and K104, and accelerated ubiquitin–proteasome-mediated degradation of M1. The recombinant IAV with mutant M1 (K102 R/K104 R) could not be rescued, suggesting that the ubiquitination of M1 at K102/K104 was essential for IAV replication. Furthermore, CypA inhibited AIP4-mediated M1 ubiquitination by impairing the interaction between AIP4 and M1. More importantly, both the mutations of M1 (K102 R/K104 R) and CypA inhibited the nuclear export of M1, indicating that CypA regulates the cellular localization of M1 via inhibition of AIP4-mediated M1 ubiquitination at K102 and K104, which results in the reduced replication of IAV.Collectively, our findings reveal a novel ubiquitination-based mechanism by which CypA regulates the replication of IAV. | Madina Mahesutihan Weinan Zheng Liang Cui Yun Li Pengtao Jiao Wenxian Yang Wei Liu Jing Li Wenhui Fan Limin Yang Wenjun Liu Lei Sun | 2018 | Virologica Sinica2018，33，5： | 3 |
| 2 | A 2.5 kb NcoI fragment of Ogura radish mitochondrial DNA is correlated with cytoplasmic male-sterility in Brassica cybrids显示文摘 | Sandrine Bonhomme Fran?oise Budar Madina Férault Georges Pelletier | 1991 | Current Genetics1991，，2： | 1 |
| 3 | Smectite in acute diarrhea in children : a double - blind placebo - controlled clinical trial显示文摘 | MADKOUR A A MADINA E M EL- AZZOUNI O E | 1993 | J Pediatr Gastroenterol Nutr1993，17，2： | 1 |
| 4 | Molecular cloning and characterization of one member of 3 betahydroxy sterol glucosyltransferase gene family in Withania somnifera 显示文摘 | SHARMA L K MADINA B M CHATURVEDI P | 2007 | Arch Biochem Biophy2007，460，1： | 1 |
| 5 | Evaluation of captopril versus reserpine and frusemide in treating hypertensive children with acute post-streptococcal glomerulonephritis显示文摘 | Morsi MR Madina EH Anglo AA | | 0，，02： | 1 |
| 6 | Smectite in acute diarrhea in childern: a double blind placebo-controlled clinical trial 显示文摘 | Ahmed A M Ekram M Madina H | 1993 | J Pediatric Gastrenterology and Nutrition1993，17，2： | 1 |
| 7 | The enhancement of the oxidation resistance of carbonyl iron by polyaniline coating and consequent changes in electromagnetic properties显示文摘 | Madina A. Abshinova Natalia E. Kazantseva Petr Sáha Irina Sapurina Jana Ková?ová Jaroslav Stejskal | 2008 | Polymer Degradation and Stability2008，，10： | 1 |
| 8 | Smectite in acute diarrhea in children:a double-blind placebo-controlled clinical trial显示文摘 | Ahmed AM Ekram M Madina H | 1993 | J Pediatr Gastrenterol Nutr1993，17，： | 1 |
| 9 | Relationship between growth hormone concentrations in bovine oocytes and follicular fluid and oocyte developmental competence显示文摘 | Borromeo V Lueiano AM | 2007 | Eur J Histochem2007，51，3： | 1 |
| 10 | Toluene inhalation produces a conditioned place preference in rats显示文摘 | Madina RG Lauren C Abbie F | 2003 | European Journal of Pharmacology2003，477，1： | 1 |
| 11 | Purification and physico-kinetic characterization of 3beta-hydroxy specific sterol glucosyltransferase fromWithania somnlfera (L) and its stress response 显示文摘 | Madina B R Sharma L K Chaturvedi P | 2007 | Biochim Biophys Acta2007，1774，3： | 1 |
| 12 | Purification and physico-kinetic characterization of 3beta-hydroxy specific steml glucosyltransferase from Withania somnifera (L) and its stress response 显示文摘 | Madina B R Sharma L K Chaturvedi P | 2007 | Biochim Biophys Acta2007，1774，3： | 1 |
| 13 | The relation between temperature, ozone, and mortality in nine French cities dur- ing the heat wave of 2003 显示文摘 | Filleul L Cassadou S Madina S | 2006 | Environmental Health Perspectives2006，114，9： | 1 |
| 14 | Smectite in acute diarrhea in childern:a double-blind placebo-controlled clinical trial 显示文摘 | Ahmed AM Ekram M Madina H | 1993 | J Pediatr Gastrenterol Nutr1993，17，： | 1 |
| 15 | “光明之路”与“丝绸之路经济带”的对接路径显示文摘'光明之路——通往未来之路'计划是新时期哈萨克斯坦一项重要的经济政策。作为'丝绸之路经济带'的关键枢纽,哈萨克斯坦实施的'光明之路'新经济政策在时间与空间上与'丝绸之路经济带'高度契合。实现'丝绸之路经济带'与'光明之路'的对接为哈中互利合作的进一步发展奠定了良好基础,有利于两国在合作中产生互惠、互利、互赢的良好发展局面。 | Bekmukhambetova Madina | 2018 | 企业科技与发展2018，，4： | 1 |
| 16 | Stabilization of lateritic soils with phosphoric acid 显示文摘 | Madina J Guida H N | 1996 | International Journal of Rock Mechanics and Mining Science & GeomechanicsAbstracts1996，，6： | 1 |
| 17 | Advantages and disadvantages of one-stage and two-stage surgery for arrhythmias and Ebstein' s anomaly显示文摘 | Leo B Elena G Madina D | 2005 | Eur J Cardiovasc Surg2005，28，： | 1 |
| 18 | Smectite in Acute Diarrhea in Children: A Double-Blind Placebo-Controlled Clinical Trial显示文摘 | Ahmed A. Madkour Ekram M. H. Madina Omar E. Z. El-Azzouni Maysa A. Amer Tarek M. K. El-Walili Tarek Abbass | 1993 | Journal of Pediatric Gastroenterology and Nutrition1993，，： | 1 |
| 19 | Journal of Pediatric Gastroenterology & Nutrition 显示文摘 | Madkour Ahmed A Madina Ekram M H El-Azzouni Omar E Z | 1993 | 17(2): 176-1811993，17，2： | 1 |
| 20 | Smectite in acute diarrhea in children: adouble -blindplacebo -controlledclinical trial 显示文摘 | Ahmed AM Ekram M Madina H etal | 1993 | JPediatric Gaserenterology and Nutrition1993，17，： | 1 |
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