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| 1 | Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs显示文摘Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic tests.Often,high-throughput approaches are applied to discover biomarker signatures.These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches.Previously,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and Germany.Here,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR.We computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from controls.Further,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and B-cells.Our study represents the next important step in translational research for a miRNA-based AD test. | Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 2 | High altitude journeys and flights are associated with an increased risk of flares in inflammatory bowel dis- ease patients显示文摘 | VAVRICKA S R ROGLER G MAETZLER S | 2014 | J Crohns Colitis2014，8，： | 1 |
| 3 | Impaired trunk stability in individuals at high risk for Parkinson' s disease 显示文摘 | Maetzler W Mancini M Liepelt-Scarfone I | 2012 | PloS one2012，7，32： | 1 |
| 4 | Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebro- spinal fluid and serum of patients with early Alzheimer's dis- ease and normal eontrols显示文摘 | Straten G Eschweiler GW Maetzler W | 2009 | J Alzheimers Dis2009，18，2： | 1 |
| 5 | High altitude journeys and flights are associated with an increased risk of flares in inflammatory bowel disease patients 显示文摘 | Vavricka SR Rogler G Maetzler S | 2014 | J Crohns Colitis2014，8，3： | 1 |
| 6 | Risk for femoral fractures in Parkinson's disease patients with and without severe functional impairment显示文摘 | BENZINGER P RAPP K MAETZLER W | 2014 | Plos One2014，9，5： | 1 |
| 7 | Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-FDG-PET显示文摘 | Liepeh I Reimold M Maetzler W | 2009 | Mov Disord2009，24，10： | 1 |
| 8 | Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias显示文摘 | Maetzler W Berg D Synofzik M | | Journal of Alzheimer's Disease0，，： | 1 |
| 9 | Normal pressure values and repeatability of the Emed(R) ST2 system显示文摘 | Maetzler M Bochdansky T | 2010 | Gait Posture2010，32，3： | 1 |
| 10 | Progression of Parkinson's disease in the clinical phase:potential markers显示文摘 | Maetzler W Liepelt I Berg D | 2009 | Lancet Neurol2009，8，： | 1 |
| 11 | Progression of Parkinson's disease in the clinical phase:Potential markers显示文摘 | Maetzler W Liepelt I Berg D | | 0，，： | 1 |
| 12 | S100B is increased in Parkin- son'sdisease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-a pathway 显示文摘 | Sathe K Maetzler W Lang JD | 2012 | Brain2012，135，11： | 1 |
| 13 | Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration- FDG-PET 显示文摘 | Liepelt I Reimold M Maetzler W | 2009 | Mov Disord2009，24，10： | 1 |
| 14 | Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-〔18F〕FDG-PET显示文摘 | Liepelt I Reimold M Maetzler W | 2009 | Mov Disord2009，24，10： | 1 |
| 15 | 18FFDG-PET for diagnosis of dementia in Parkinson's disease显示文摘 | Reimold M Liepelt I Maetzler W | 2008 | J Nucl Med2008，491，： | 1 |
| 16 | GABAB receptor expression and celhdar localization in gerbil hippocampus after transient global ischemia显示文摘 | Vollenweider F Bendfeldt K Maetzler W | 2006 | Neurosci Lett2006，395，2： | 1 |
| 17 | Evaluation of progression markers in the premotor phase of parkirtson 's disease: the progression markers in the premotor phase study 显示文摘 | Liepelt-Scarfone I Gauss K Maetzler W | 2013 | Neuroepidemiology2013，41，34： | 1 |
| 18 | Impaired Trunk Stability in Individuals at High Risk for Parkinson's Disease显示文摘 | Maetzler W Mancini M Liepelt Scarfone I | 2012 | PLOS One2012，7，32： | 1 |
| 19 | Plasma ce-ramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment:a pilot study显示文摘 | Mielke MM Maetzler W Haughey NJ | | 0，，09： | 1 |
| 20 | Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics显示文摘 | Maetzler W Liepelt I Reimold M | | 0，，： | 1 |
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