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| 1 | 1700 nm optical coherence microscopy enables minimally invasive,label-free,in vivo optical biopsy deep in the mouse brain显示文摘In vivo,minimally invasive microscopy in deep cortical and sub-cortical regions of the mouse brain has been challenging.To address this challenge,we present an in vivo high numerical aperture optical coherence microscopy(OCM)approach that fully utilizes the water absorption window around 1700nm;where ballistic attenuation in the brain is minimized.Key issues,including detector noise,excess light source noise,chromatic dispersion,and the resolution-speckle tradeoff,are analyzed and optimized.Imaging through a thinned-skull preparation that preserves intracranial space,we present volumetric imaging of cytoarchitecture and myeloarchitecture across the entire depth of the mouse neocortex,and some sub-cortical regions.In an Alzheimer's disease model,we report that findings in superficial and deep cortical layers diverge,highlighting the importance of deep optical biopsy.Compared to other microscopic techniques,our 1700nm OCM approach achieves a unique combination of intrinsic contrast,minimal invasiveness,and high resolution for deep brain imaging. | Jun Zhu Hercules Rezende Freitas Izumi Maezawa Lee-way Jin Vivek J.Srinivasan | 2021 | Light(Science & Applications)2021，10，8： | 3 |
| 2 | Increased expression of neurotrophins and their receptors in the mechanically compressed spinal cord of the spinal hyperostotic mouse (twy/twy)显示文摘 | Uchida K Baba H Maezawa Y | 2003 | Acta Neuropathol ( Bed )2003，106，： | 1 |
| 3 | Monolithic integration of resonant tunneling diodes and FET's for monostable-bistable transition logic elements(MOBILE's)显示文摘 | Chen K J Akeyoshi T Maezawa K | 1995 | IEEE Electron Device Lett1995，16，2： | 1 |
| 4 | Mice lacking smad3 are protected against streptozotocin -induced diabetic glomerulopathy显示文摘 | Fujimoto M Maezawa Y Yokote K | 2003 | Biochem Biophys Res Commun2003，305，4： | 1 |
| 5 | Lordotic alignment and posterior migration of the spinal cord following en bloc open-door laminoplasty for cervical myelopathy:A magnetic resonance imaging study显示文摘 | Baba H Uchida K Maezawa Y | 1996 | J Neurol1996，243，9： | 1 |
| 6 | Cervical myelomdiculopathy with entrapment neuropathy: a study based on the double-crush concept显示文摘 | Baba H Maezawa Y Uchida K | 1998 | Spinal Cord1998，36，39： | 1 |
| 7 | Polymorphisms in alcoholic metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients:a multivariate analysis显示文摘 | Yamauchi M Maezawa Y Mizuhara Y | 1995 | Hepatology1995，22，： | 1 |
| 8 | Quantitative analysis of the spinal cord motoneuron under chronic compression:an experimental observation in the mouse显示文摘 | Baba H Maezawa Y Imura S | 1996 | J Neurol1996，243，2： | 1 |
| 9 | 查看详情显示文摘 | Nishino M N Fujimoto M Maezawa K | | 0，，： | 1 |
| 10 | IL-23 and Th17 cells enhance Th2-cell-mediated eosisophilic airway inflammation in mice显示文摘 | Wakashin H Hirose K Maezawa Y | 2008 | Am Respir Crit Care Med2008，178，10： | 1 |
| 11 | Reset-set flipflop based on a novel approach of modulating resonant-tunneling current with FET gates 显示文摘 | Chen K Akeyoshi T Maezawa K | 1994 | Electronics Letters1994，30，21： | 1 |
| 12 | Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion 显示文摘 | Feng-Shiun Shie Neely MD Maezawa I | 2004 | Am J Pathol2004，164，： | 1 |
| 13 | Functions and applications of monostable-bistable transition logic el- ements (MOBILE′s) having multiple-input terminals 显示文摘 | Maezawa K Akeyoushi T Mizutani T | 1994 | IEEE Transaction on Electron Devices1994，41，2： | 1 |
| 14 | IL-23 and Th17 cells enhance Thl2-cell-mediated eosinophilic airway inflammation in mice显示文摘 | Wakashin H Hirose K Maezawa Y | 2008 | Am J Respir Crit Care Med2008，178，10： | 1 |
| 15 | Marked increase in serum KL-6 and surfaetant protein D levels during the first 4 weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/ dermatomyositis显示文摘 | Arai S Kurasawa K Maezawa R | 2013 | Mod Rheumatol2013，23，5： | 1 |
| 16 | Therapeutic effects of ulinastatin on experimental crescentic glomerulonephritis in rats显示文摘 | Oizumi R Kanai H Maezawa A | | 0，，： | 1 |
| 17 | Expression of various growth factors for cell proliferation and cytod- ifferentiation during fracture repair of bone 显示文摘 | Tat suyama K Maezawa Y Baba H | 2000 | Eur J Histochem2000，44，3： | 1 |
| 18 | Advanced glycation endproduct precursor alters intracellular amytoid-beta/A beta PP carboxy-termi- nal fragment aggregation and cytotoxicity显示文摘 | Woltjer RL Maezawa I Ou JJ | 2003 | J Alzheimers Dis2003，5，6： | 1 |
| 19 | Cell biology of dia- betic nephropathy:roles of endothelial cells, tubulointer- stitial cells and podocytes显示文摘 | Maezawa Y Takemoto M Yokote K | 2015 | J Diabetes Investig2015，，： | 1 |
| 20 | Functions and applications of monostable-bistable transition logic elements (MOBILE's) having multiple-input terminals 显示文摘 | MAEZAWA K AKEYOSHI T MIZUTANI T | 1994 | IEEE Trans on ED1994，41，2： | 1 |
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