|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Acute compression and lengthening by Ilizarov technique for infected nonunion of the tibia with large bone defects显示文摘 | Magadum MP Basavaraj CM Phaneesha MS | 2006 | J Orthop Surg (HK)2006，14，3： | 1 |
| 3 | Gene duplication as a ma jor force in evolution显示文摘 | Magadum S Banerjee U Murugan P | 2013 | Journal of Genetics2013，92，1： | 1 |
| 4 | Acute compres- sion and lengthening by the Ilizarov technique for infected nonunion of the tibia with large bone defects显示文摘 | Magadum MP Basavaraj YC Phaneesha MS | 2006 | J Orthop Surg (Hong Kong)2006，14，3： | 1 |
| 5 | Acute compression and lengthening by the Ilizarov technique for infected nonunion of the tibia with large bone defects显示文摘 | Magadum MP Yadav CM Phaneesha MS | | 0，，： | 1 |
| 6 | Identification of chemicals in- ducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells 显示文摘 | Uosaki H Magadum A Seo K | 2013 | Circ Cardiovasc Genet2013，6，6： | 1 |
| 7 | Acute compression and lengthening by the Ilizarov technique for infected nonunion of the tibia with large bone defects 显示文摘 | Magadum MP Yadav CM Phaneesha MS | 2006 | J Orthop Surg( Hong Kong)2006，3，： | 1 |
| 8 | Acute Compression and Lengthening by the I1- izarov technique for infected nonunion of the tibia with large bone defects 显示文摘 | Magadum MP Basavaraj - Yadaw CM Phaneesha MS | 2006 | J Orthop Surg ( Hong Kong)2006，14，3： | 1 |
| 9 | Gene duplication as a major force in evolution显示文摘 | Magadum S Banerjee U Murugan P | 2013 | Journal of Genetics2013，92，1： | 1 |
| 10 | Enhancement of sta- bility for mandibular complete denture prosthesis in atro- phied ridge with neutral zone technique-A case report显示文摘 | Patil V Hallikerimath RB Magadum S | 2011 | Journal of Advanced Dental Research2011，2，1： | 1 |
| 11 | Acutecompression and lengthening by the Ilizarov technique for infectednonunion of the tibia with large bone defects 显示文摘 | Magadum MP Basavaraj-Yadav CM Phaneesha MS | 2006 | J Orthop Sui^(Hong Kong)2006，3，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员