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| 1 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 2 | Steroids of the marine sponge Cinachyra tarentina: isolation of cholest- 4-ene-3, 6-dione and (24R)-24-ethylcholest-4-ene-3, 6- dione 显示文摘 | Aiello A Fattorusso E Magno S | 1991 | JNatProd1991，54，1： | 1 |
| 3 | How good is cap- sule endoscopy for detection of periampullary lesions? Results of a tertiary - referral center显示文摘 | CLARKE J O GIDAY S A MAGNO P | 2008 | Gastrointest Endosc2008，68，2： | 1 |
| 4 | Ultrasound in enzymatic resolution of ethyl 3-hydroxy-3-phenylpropanoate 显示文摘 | Carlos Magno R Ribeiro Elisa N Passaroto Eugenia C S Brenelli | 2001 | Tetrahedron Letters2001，42，： | 1 |
| 5 | Facile synthesis of meso-tetrakis(perfluoroalkyl)porphyrins:spectroscopic properties and X-ray crystal structure of highly electron-deficient 5,10,15,20-tetrakis(heptafluoropropyl)porphyrin显示文摘 | Di Magno S G Williams R A Therien M J | 1994 | J Org Chem1994，59，23： | 1 |
| 6 | Early onset lactating adenoma and the role of breast MRI: a case report显示文摘 | Magno S Terribile D Franeeschini G etal | 2009 | J Med Case Rep2009，3，： | 1 |
| 7 | Conservative and radical oneoplastic approches in the surgical treatment of breast cancer 显示文摘 | Franceschini G Magno S Fabbri C | 2008 | Eur Rev Med Pharmacol Sci2008，12，6： | 1 |
| 8 | Stereo-Based All-Terrain Obstacle Detection Using Visual Saliency显示文摘 | Pedro S Magno G Luis C el al | 2011 | Journal of Field Robotics2011，28，2： | 1 |
| 9 | Breast MRI in a case of 'early onset' lactating adenoma显示文摘 | Magno S Terribile D Franceschini G etal | 2009 | Breast J2009，15，1： | 1 |
| 10 | Early onset lactating adenoma and the role of breast MRI : a case report 显示文摘 | Magno S Terribile D Franceschini G | 2009 | J Med Case Reports2009，3，： | 1 |
| 11 | Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES显示文摘 | Kim M S Magno C L Day C J | 2006 | J Cell Biochem2006，97，3： | 1 |
| 12 | Determination of moxifloxacin in tables and human urine by square- wave adsorptive voltammetry 显示文摘 | Magno A G T Glaucia M S Valdir S F | 2005 | Microchemical Journal2005，81，： | 1 |
| 13 | Update in the treatment of locally advanced breast cancer: a multidisciplinary approach 显示文摘 | Franceschini G Terribile D Magno S | 2007 | Eur Rev Med Pharmacol Sci2007，11，5： | 1 |
| 14 | 显示文摘 | D a 1 la R A Loffier D G Magno S | 1997 | Prepr Am Chem Soc Div Petrol Chem1997，，42： | 1 |
| 15 | Oncoplastic techniques in the conservative surgieal treatment of breast cancer 显示文摘 | Masetti R Pirulli PG Magno S | 2000 | Breast Cancer2000，7，4： | 1 |
| 16 | Cat scratch disease in primary care显示文摘 | Magno S L Spatar L | 2009 | J Nurse Practitioners2009，5，5： | 1 |
| 17 | Design, synthesis and photobiological properties of 3 , 4-cyclopentenepsoralens显示文摘 | Gia 0 Magno S M Gonzalez-Dfaz H | 2005 | Bioorg Med Chern2005，13，： | 1 |
| 18 | Sterols of mediterranean cholrophyceae显示文摘 | Fattorusso E Magno S Mayol L | 1980 | Experientia1980，36，10： | 1 |
| 19 | Does bromodomain flexibility influence histone recognition? 显示文摘 | Steiner S Magno A Huang D | 2013 | FEBS Lett2013，587，14： | 1 |
| 20 | New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity 显示文摘 | Dalla Via L Gia O Marciani Magno S | 1999 | J Med Chem1999，42，： | 1 |
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