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| 1 | Coinfection with hepatitis C virus and schistosomiasis:Fibrosis and treatment response显示文摘AIM:To assess whether schistosomiasis coinfection with chronic hepatitis C virus (HCV) influences hepatic fibrosis and pegylated-interferon/ribavirin (PEG-IFN/ RIB) therapy response. METHODS:This study was designed as a retrospective analysis of 3596 chronic HCV patients enrolled in the Egyptian National Program for HCV treatment with PEG-IFN/RIB. All patients underwent liver biopsy and anti-schistosomal antibodies testing prior to HCV treatment. The serology results were used to categorize the patients into group A (positive schistosomal serology) or group B (negative schistosomal serology). Patients in group A were given oral antischistosomal treatment(praziquantel, single dose) at four weeks prior to PEG-IFN/RIB. All patients received a 48-wk course of PEG-IFN (PEG-IFNα2a or PEG-IFNα2b)/RIB therapy. Clinical and laboratory follow-up examinations were carried out for 24 wk after cessation of therapy (to week 72). Correlations of positive schistosomal serology with fibrosis and treatment response were assessed by multiple regression analysis. RESULTS:Schistosomal antibody was positive in 27.3% of patients (15.9% females and 84.1% males). The patients in group A were older (P = 0.008) and had a higher proportion of males (P = 0.002) than the patients in group B. There was no significant association between fibrosis stage and positive schistosomal serology (P = 0.703). Early virological response was achieved in significantly more patients in group B than in group A (89.4% vs 86.5%, P = 0.015). However, significantly more patients in group A experienced breakthrough at week 24 than patients in group B (36.3% vs 32.3%, P = 0.024). End of treatment response was achieved in more patients in group B than in group A (62.0% vs 59.1%) but the difference did not reach statistical significance (P = 0.108). Sustained virological response occurred in significantly more patients in group B than in group A (37.6% vs 27.7%, P = 0.000). Multivariate logistic regression analysis of patient data at treatment weeks 48 and 72 showed that positive schistosomal serology was associated with failure of response to treatment at week 48 (OR = 1.3, P = 0.02) and at week 72 (OR = 1.7, P < 0.01). CONCLUSION:Positive schistosomal serology has no effect on fibrosis staging but is significantly associated with failure of response to HCV treatment despite antischistosomal therapy. | Mahasen Abdel-Rahman Mohammad El-Sayed Maissa El Raziky Aisha Elsharkawy Wafaa El-Akel Hossam Ghoneim Hany Khattab Gamal Esmat | 2013 | World Journal of Gastroenterology2013，19，17： | 1 |
| 2 | Arachnoid granulations in the cerebral dural sinuses as demonstrated by contrast-enhanced 3D magnetic resonance venography显示文摘 | Azmi A. Haroun Waleed S. Mahafza Mahasen S. Al Najar | 2007 | Surgical and Radiologic Anatomy2007，，4： | 1 |
| 3 | Cystoscopic extraction of an inadvertently placed ureteral stent in inferior vena cava显示文摘Dear Editor,A stent is a tube kept within a tubular structure to maintain luminal patency or protect an anastomosis or graft.In urological practice ureteral stents are inserted to relieve ureteral obstruction,to support ureteral anastomoses and repairs,to treat minor ureteric injuries,and to identify the ureters at open surgery.During insertion,ureteral stents may pierce the ureteric wall and enter adjacent structures. | Ambegoda Liyana Arachchige Madura Chathuranga Ambegoda Kusala Sandamalee Anuruddha Mahasen Abeygunasekera | 2020 | Asian Journal of Urology2020，7，4： | 0 |
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