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| 1 | In silico identification and characterization of common epitope-based peptide vaccine for Nipah and Hendra viruses显示文摘Objective: To explore a common B-and T-cell epitope-based vaccine that can elicit an immune response against encephalitis causing genus Henipaviruses, Hendra virus(He V) and Nipah virus(Ni V). Methods: Membrane proteins F, G and M of He V and Ni V were retrieved from the protein database and subjected to different bioinformatics tools to predict antigenic B-cell epitopes. Best B-cell epitopes were then analyzed to predict their T-cell antigenic potentiality. Antigenic B-and T-cell epitopes that shared maximum identity with He V and Ni V were selected. Stability of the selected epitopes was predicted. Finally, the selected epitopes were subjected to molecular docking simulation with HLA-DR to confirm their antigenic potentiality in silico. Results: One epitope from G proteins, one from M proteins and none from F proteins were selected based on their antigenic potentiality. The epitope from the G proteins was stable whereas that from M was unstable. The M-epitope was made stable by adding flanking dipeptides. The 15-mer G-epitope(VDPLRVQWRNNSVIS) showed at least 66% identity with all Ni V and He V G protein sequences, while the 15-mer M-epitope(GKLEFRRNNAIAFKG) with the dipeptide flanking residues showed 73% identity with all Ni V and He V M protein sequences available in the database. Molecular docking simulation with most frequent MHC class-II(MHC II) and class-I(MHC I) molecules showed that these epitopes could bind within HLA binding grooves to elicit an immune response. Conclusions: Data in our present study revealed the notion that the epitopes from G and M proteins might be the target for peptide-based subunit vaccine design against He V and Ni V. However, the biochemical analysis is necessary to experimentally validate the interaction of epitopes individually with the MHC molecules through elucidation of immunity induction. | Chayan Kumar Saha Mahbub Hasan Saddam Hossain Asraful Jahan Abul Kalam Azad | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，6： | 0 |
| 2 | Doping radius effects on an erbium-doped fiber amplifier显示文摘In an erbium-doped fiber amplifier(EDFA), erbium ions act as a three-level system. Therefore, much higher pump energy is required to achieve the population inversion in an erbium-doped fiber(EDF). This higher pump energy requirement complicates the efficient design of an EDFA. However, efficient use of the pump power can improve the EDFA performance. The improved performance of an EDFA can be obtained by reducing the doping radius of the EDF. A smaller doping radius increases pump–dopant interactions and subsequently increases the pump–photon conversion efficiency. Decreasing the doping radius allows a larger proportion of dopant ions,which are concentrated near the core, to interact with the highest pump intensity. However, decreasing the doping radius beyond a certain limit will bring the dopant ions much closer and introduce detrimental ion–ion interaction effects. In this Letter, we show that an optimal doping radius in an EDF can provide the best gain performance. Moreover, we have simulated the well-known numerical aperture effects on EDFA gain performance to support our claim. | Ziaul Amin Khurram Karim Qureshi Mahbub Hossain | 2019 | Chinese Optics Letters2019，17，1： | 0 |
| 3 | Self-compassion and resilience mediate the relationship between childhood exposure to domestic violence and posttraumatic growth/stress disorder during COVID-19 pandemic显示文摘BACKGROUND Studies have indicated that childhood exposure to domestic violence is a common factor in posttraumatic growth(PTG)and posttraumatic stress disorder(PTSD),but it is unclear whether PTG and PTSD share a common/different underlying mechanism.AIM To explore the common/different underlying mechanism of PTG and PTSD.METHODS Between February 12 and 17,2020,a nationwide cross-sectional online survey was conducted in China among 2038 university students,and a self-administered questionnaire was used for the data collection.The data included demographic characteristics,such as age,gender,and subjective social economic status,and childhood exposure to domestic violence scale that was selected from the Chinese version of revised Adverse Childhood Experiences Question,Self-compassion Scale,Connor–Davidson Resilience Scale,Posttraumatic Growth Inventory,and the Abbreviated PTSD Checklist-Civilian version.A structural equation model was used to test the hypotheses.RESULTS Exposure to domestic violence was significantly associated with PTG and PTSD via a 1-step indirect path of self-compassion(PTG:β=-0.023,95%CI:-0.44 to-0.007;PTSD:β=0.008,95%CI:0.002,0.014)and via a 2-step indirect path from self-compassion to resilience(PTG:β=-0.008,95%CI:-0.018 to-0.002;PTSD:β=0.013,95%CI:0.004-0.024).However,resilience did not mediate the relationship between exposure to domestic violence and PTG and PTSD.CONCLUSION PTG and PTSD are common results of childhood exposure to domestic violence,which may be influenced by self-compassion and resilience. | Xin-Li Chi Qiao-Min Huang Xiao-Feng Liu Liu-Yue Huang Meng-Jian Hu Zhi-Jing Chen Can Jiao Brendon Stubbs M Mahbub Hossain Li-Ye Zou | 2021 | World Journal of Psychiatry2021，11，11： | 0 |
| 4 | Association between Active School Travel and Depressive Symptoms among 51,702 Adolescents in 26 Low- and Middle-Income Countries显示文摘Little is known about the role of active school travel(AST)on mental health among adolescents.Thus,this study aimed to explore the AST-depression association among adolescents aged 12–15 years from 26 low-and middle-income countries(LMICs).Data from the Global School-based Student Health Survey were analyzed in 51,702 adolescents[mean(SD)age 13.8(1.0)years;49.3%boys).Both depressive symptoms and AST were assessed by a single question self-reported measure,respectively.Participants who reported having 5 days or above were considered as AST.Multivariable logistic regression analysis(accounting for sampling weights)was performed while controlling for gender,age,physical activity,sedentary behavior,and food insecurity,and a countrywide meta-analysis was undertaken.The prevalence of depressive symptoms and AST were 30.1%and 37.0%,respectively.Compared with those not having AST,adolescents with AST were less likely to have self-reported depressive symptoms(OR=0.88,95%CI:0.85-0.93)regardless of gender.Countrywide meta-analysis demonstrated that having AST versus not having AST was associated with 12%lower odds for depressive symptoms(OR=0.88;95%CI:0.82-0.94)but with a moderate between-country heterogeneity(I^(2)=59.0%).Based on large samples of adolescents from LMICs,it would be expected that AST may play a critical role in preventing adolescent depression worldwide.However,it is necessary to consider more country-specific factors when implementing AST-related mental health interventions.Future studies should adopt the solid study design to confirm or negate our researchfindings. | Shuan Liu Sitong Chen Xiaohong Zhu Brendon Stubbs Qian Yu Mark D.Griffiths Can Jiao Aiguo Chen Md Mahbub Hossain Zsolt Demetrovics Albert S.Yeung Jinming Li Xingyu Zhang Liye Zou | 2021 | International Journal of Mental Health Promotion2021，23，2： | 0 |
| 5 | Meeting 24-h Movement Guidelines is Related to Better Academic Achievement:Findings from the YRBS 2019 Cycle显示文摘This research is designed to investigate the relationship between the 24-h movement guidelines(24-HMG)and self-reported academic achievement(AA)using nationally representative data derived from the 2019 U.S.National Youth Risk Behaviour Survey.A multiple-stage cluster sampling procedure has been adopted to ensure a representative sample(N=9127 adolescents;mean age=15.7 years old;male%=49.8%).Logistic regression has been adopted to obtain the odds ratio(OR)regarding the associations between adherence to 24-HMG and AA while controlling for ethnicity,body mass index,sex and age.The prevalence of meeting the 24-h movement guidelines in isolation and combination varied greatly(physical activity=23.3%,screen time=32.5%,sleep=22.3%,and 24-HMG=2.8%),while the percentage of highest-class AA was 42.5%.Compared with the situation when none of 24-HMG is met,the achievement of any of the combined guidelines(except for meeting the physical activity guidelines)was significantly associated with higher odds of achieving first-class AA.Meeting the sleep guideline had 1.42 times increased likelihood to achieve highest-class AA as compared with not meeting the sleep guideline.Meeting screen time guidelines and physical activity guidelines,respectively,were 1.32 and 1.13 times more likely to report first-class AA;but meeting the guidelines of physical activity was not significantly related to AA.Meeting the 24-HMG had the highest odds of achieving first-class AA(OR=2.01,95%CI:1.47-2.73).In both sexes,adolescents who met 24-HMG self-reported better AA(boys OR=2.05,95%CI:1.34-3.15;girls OR=2.26,95%CI:1.36-3.76).Significant relationships were observed in adolescents from 9-10th grade,but not higher grades.Our research findings suggest that optimal movement behaviours can be seen as an important element to better academic achievement among U.S.adolescents.Future studies can adopt our discoveries to promote adolescents’academic achievement through implementing optimal 24-h movement behaviour patterns. | Shaoying Liu Qian Yu Md Mahbub Hossain Scott Doig Ran Bao Yaping Zhao Jin Yan Xun Luo Jiaxuan Yang Arthur F.Kramer Liye Zou | 2022 | International Journal of Mental Health Promotion2022，24，1： | 0 |
| 6 | Analysis of Immune Responses and Serological Cross Reactivities among Vibrio cholerae O1,Shigella flexneri 2a and Haemophilus influenzae b显示文摘Antigenic determinants expressed on the bacterial cell surface are of importance in the serological characterization and microbiological diagnosis. The bacterial strains carrying these identical or similar antigenic epitopes might react with antibodies produced against other strains. In this study, strong immunogenicity and antigenic cross reactivity were demonstrated among V. cholerae O1, S. flexnerii 2a and H. influenzae b surface components. The enzyme linked immunosorbent assay (ELISA) results were supported by Western blot analysis, where at least 20 antigenic bands, were obtained in each of the reactions, when the surface components were reacted with the homologous antisera. The indirect ELISA results also demonstrated high degree of antigenic relatedness between the surface components of these species, where each surface component was reacted with the heterologous antisera. Western blot analysis also revealed cross reactions between the surface components suggesting common distribution of antigens/epitopes in these bacterial species. This study, thus, gave a clear idea of the level of antigenic sharing and variations among the pathogenic V. cholerae O1, S. flexneri 2a and H. influenzae b strains, which in future, may help in selecting a proper candidate for vaccines and immunodiagnostics development. | Fazle Rabbi Nasreen Sultana Tasmina Rahman H. M. Al-Emran M. Nizam Uddin Mahbub Hossain Kazi Selim Anwar Mahmuda Yasmin Jamalun Nessa Chowdhury R. Ahsan | 2008 | Cellular & Molecular Immunology2008，5，5： | 0 |
| 7 | Rural-urban differences in distributions and determinants of facility delivery among women in Bangladesh显示文摘Introduction:The utilization of facility delivery is crucial to achieve sustainable development goals by reducing maternal and neonatal deaths.This study aimed to compare the distributions and determinants of childbirth in health facilities in urban and rural regions of Bangladesh.Methods:Cross-sectional data from the 2017-2018 Bangladesh Demographic and Health Survey were analyzed.Multilevel logistic regression was applied.Results:A total of 4751 women were included in the analyses.Only 50%of childbirths took place in health facilities,63.4%and 44.6%in urban and rural regions,respectively.Overall,the odds of the association between facility delivery and the studied factors were similar.Multiparous women had significantly lower odds of facility delivery in both rural(adjusted odds ratio[AOR]=0.3,95%confidence interval[CI]:0.2 to 0.5)and urban(AOR=0.2,95%CI:0.1 to 0.5)regions.In both regions,women with higher education levels,highly educated husbands,antenatal care(ANC),and higher wealth indexes had significantly higher odds of facility delivery.Conclusion:Several common associated factors were identified.However,differences were observed regarding distributions of these factors.The differences in facility delivery utilization could result from lower ANC utilization,socioeconomic status,and transportation facilities in rural regions than urban regions;therefore,improving these conditions could increase facility delivery in these regions. | Jannatun Nayeem Christina Stennett Atia Sharmeen Md Mahbub Hossain Gulam Muhammed Al Kibria | 2023 | Global Health Journal2023，7，4： | 0 |
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