4篇
您的检索式：作者名="Mahmoud TA"
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| 1 | Genetic dissection of memory for associative and non‐associative learning in Caenorhabditis elegans显示文摘 | Lau HL Timbers TA Mahmoud R | 2013 | Genes Brain Behav2013，12，： | 1 |
| 2 | Power generation using spinel manganese cobalt oxide as a cathode catalyst for microbial fuel cell applications显示文摘 | Mahmoud M Gad-Allah TA E1-Khatib KM | 2011 | Biores Techn ol2011，102，10： | 1 |
| 3 | Adaptive regulariza- tion-based super resolution reconstruction technique for multi- focus low-resolution images 显示文摘 | Bahy RM Salama GI Mahmoud TA | 2014 | Signal Processing2014，103，10： | 1 |
| 4 | A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme显示文摘The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy exists.Ionizing radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing osteoclast.We demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic bone.At reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic activities.These properties make cerium oxide nanomaterials fascinating.We show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and strength.These investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in vivo.Further,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in vitro.These findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials. | Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup | 2023 | Bioactive Materials2023，，3： | 0 |
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