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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Optimization of actinomycin V production by Streptomyces triostinicus using artificial neural network and genetic algorithm 显示文摘 | Vineeta S Mahvish K Saif K | 2009 | Applied Microbiology and Biotechnology2009，82，2： | 1 |
| 3 | Structured condition numbers and statistical condition estimation for the LDU factorization显示文摘In this article, we consider the structured condition numbers for LDU, factorization by using the modified matrix-vector approach and the differential calculus, which can be represented by sets of parameters. By setting the specific norms and weight parameters, we present the expressions of the structured normwise, mixed, componentwise condition numbers and the corresponding results for unstructured ones. In addition, we investigate the statistical estimation of condition numbers of LDU factorization using the probabilistic spectral norm estimator and the small-sample statistical condition estimation method, and devise three algorithms. Finally, we compare the structured condition numbers with the corresponding unstructured ones in numerical experiments. | Mahvish Samar Aamir Farooq MU Chun-lai | 2020 | Applied Mathematics(A Journal of Chinese Universities)2020，35，3： | 1 |
| 4 | Optimization of actinomycin V production by Streptomyces triostinicus using artificial neural network and genetic algorithm显示文摘 | Vineeta Singh Mahvish Khan Saif Khan C. K. M. Tripathi | 2009 | Applied Microbiology and Biotechnology2009，，2： | 1 |
| 5 | Epidemiology of Polio virus infection in Pakistan and possible risk factors for its transmission显示文摘End Polio Pakistan program still has to overcome many hurdles;unfortunately on 8th February2016 first polio case of the year has surfaced in Karachi.It seems that battle against polio demands little bit more conviction and motivation.WHO has set a goal of polio eradication in Pakistan till 2018,in order to evaluate the success of this target;polio eradication campaign in Pakistan has been analyzed in different perspectives.Our analysis indicated that major obstacles in eradication are low literacy rate,poor health infrastructure,lack of planning,natural disaster,economic crisis,counter insurgencies and almost no protection for polio health workers.WHO has allocated new funds to tackle this problem,now there is a need to spend this money more effectively with proper planning and honest deployment of funds. | Mahvish Kabir Muhammad Sohail Afzal | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，11： | 1 |
| 6 | Epidemiology and Control of Congo Fever in Sacrificial Animals of Pakistan显示文摘The cases and deaths due to Crimean-Congo haemorrhagic fever(CCHF)virus commonly known as Congo virus(fatality rate 15%)have been reported throughout Pakistan from the last few years especially during religious occasion,Eid-ul-Azha.The annual increase in death rates due to CCHF demonstrate the importance of awareness of Congo fever at academia as well as public level.The symptoms of Congo fever which appear one to nine days after tick bite,include sudden high fever,muscle aches,abdominal pain,headache,dizziness,sore eyes,jaundice,mood swings,confusion,aggression,and sensitivity to light.The other signs include sore throat,joint pain,vomiting,diarrhea,hemorrhages,and bleeding from skin and large intestine.The Infection has been reported in many species of wild as well as domestic animals including hares,cattle,sheep,goats,dogs,mice and hedgehogs.At least 31 species of Hyalomma,Boophilus,Rhipicephalus,Dermacentor(Ixodidae:hard ticks)act as vector of CCHF in which transovarial,transstadial and venereal transmission occurs.The virus attacks the immune system of the host and influences the immune cells.The Congo fever virus can be isolated from blood,plasma and many body tissues(kidneys,liver,spleen,lungs,brain and bone marrow).Mice inoculation,enzyme-linked immunosorbent assay(ELISA),reverse transcription polymerase chain reaction(RT-PCR)can be used for detection of the infection.Furthermore,IgM and IgG antibodies against CCHFV can also be detected and quantified.Education of general public,tick control with acaricides,use of anti-CCHFV immunoglobulin,usage of approved repellents to prevent tick bites,wearing neutral-coloured garments,application of a permethrin spray to the clothing,avoiding tall grasses and shrubs,applying sunscreen,avoiding direct contact with the blood or tissues of animals are the factors for successful prevention of the infection. | Hafiz Muhammad Rizwan Muhammad Sohail Sajid Haider Abbas Muhammad Fiaz Qamar Qaiser Akram Mahvish Maqbool | 2019 | Veterinary Science Research2019，1，2： | 0 |
| 7 | Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma显示文摘BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of ICI.Deaths are reported in<5%of patients treated with ICI.There are,however,no reliable markers to predict the onset and severity of IrAEs.We tested the association between neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with ICI.AIM To test the association between NLR and PLR at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with ICI.METHODS Data was extracted from an international database from a consortium of 11 tertiary-care referral centers.NLR=absolute neutrophil count/absolute lymphocyte count(ALC)and PLR=platelet count/ALC.Cutoff of 5 was used for NLR and 300 for PLR based on literature.We also tested the association between RESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).Most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)patients.In a univariable regression model PLR>300 was significantly associated with a lower incidence of grade≥2 IrAEs(OR=0.40;P=0.044).Similarly,a trend was observed between NLR>5 and lower incidence of grade≥2 IrAEs(OR=0.58;P=0.097).Multivariate analyses confirmed PLR>300 as an independent predictive marker of grade≥2 IrAEs(OR=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(OR=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(OR=3.39;P=0.01)combinations.Antibiotic use was not associated with IrAE incidence(OR=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of grade≥2 IrAEs(OR=2.74;P<0.001),although 74%were prescribed steroids for the treatment of IrAEs.CONCLUSION Given that high baseline NLR and PLR are associated with a decreased incidence of IrAEs,lower baseline NLR and PLR may be predictive biomarkers for the appearance of IrAEs in HCC treated with ICI.This finding is in keeping with several studies in solid tumors that have shown that baseline NLR and PLR appear predictive of IrAEs. | Sirish Dharmapuri UmutÖzbek Hiren Jethra Tomi Jun Thomas U Marron Anwaar Saeed Yi-Hsiang Huang Mahvish Muzaffar Matthias Pinter Lorenz Balcar Claudia Fulgenzi Suneetha Amara Arndt Weinmann Nicola Personeni Bernhard Scheiner Tiziana Pressiani Musharraf Navaid Bertram Bengsch Sonal Paul Uqba Khan Dominik Bettinger Naoshi Nishida Yehia Ibrahim Mohamed Arndt Vogel Anuhya Gampa James Korolewicz Antonella Cammarota Ahmed Kaseb Peter R Galle Anjana Pillai Ying-Hong Wan Alessio Cortellini Masatoshi Kudo Antonio D’Alessio Lorenza Rimassa David James Pinato Celina Ang | 2023 | World Journal of Gastrointestinal Oncology2023，15，11： | 0 |
| 8 | Re ned rigorous perturbation bounds for the SR decomposition显示文摘In this article,some new rigorous perturbation bounds for the SR decomposition un-der normwise or componentwise perturbations for a given matrix are derived.Also,the explicit expressions for the mixed and componentwise condition numbers are presented by utilizing the block matrix-vector equation approach.Hypothetical and trial results demonstrate that these new bounds are constantly more tightly than the comparing ones in the literature. | Mahvish Samar Aamir Farooq | 2021 | Applied Mathematics(A Journal of Chinese Universities)2021，36，4： | 0 |
| 9 | How old is too old? In vivo engraftment of human peripheral blood stem cells cryopreserved for up to 18 years-implications for clinical transplantation and stability programs显示文摘BACKGROUND Peripheral blood stem cells(PBSC)are commonly cryopreserved awaiting clinical use for hematopoietic stem cell transplant.Long term cryopreservation is commonly defined as five years or longer,and limited data exists regarding how long PBSC can be cryopreserved and retain the ability to successfully engraft.Clinical programs,stem cell banks,and regulatory and accrediting agencies interested in product stability would benefit from such data.Thus,we assessed recovery and colony forming ability of PBSC following long-term cryopreservation as well as their ability to engraft in NOD/SCID/IL-2 Rγnull(NSG)mice.AIM To investigate the in vivo engraftment potential of long-term cryopreserved PBSC units.METHODS PBSC units which were collected and frozen using validated clinical protocols were obtained for research use from the Cellular Therapy Laboratory at Indiana University Health.These units were thawed in the Cellular Therapy Laboratory using clinical standards of practice,and the pre-freeze and post-thaw characteristics of the units were compared.Progenitor function was assessed using standard colony-forming assays.CD34-selected cells were transplanted into immunodeficient mice to assess stem cell function.RESULTS Ten PBSC units with mean of 17 years in cryopreservation(range 13.6-18.3 years)demonstrated a mean total cell recovery of 88%±12%(range 68%-110%)and post-thaw viability of 69%±17%(range 34%-86%).BFU-E growth was shown in 9 of 10 units and CFU-GM growth in 7 of 10 units post-thaw.Immunodeficient mice were transplanted with CD34-selected cells from four randomly chosen PBSC units.All mice demonstrated long-term engraftment at 12 wk with mean34%±24%human CD45+cells,and differentiation with presence of human CD19+,CD3+and CD33+cells.Harvested bone marrow from all mice demonstrated growth of erythroid and myeloid colonies.CONCLUSION We demonstrated engraftment of clinically-collected and thawed PBSC following cryopreservation up to 18 years in NSG mice,signifying likely successful clinical transplantation of PBSC following long-term cryopreservation. | John Underwood Mahvish Rahim Carijo West Rebecca Britton Elaine Skipworth Vicki Graves Steven Sexton Hillary Harris Dave Schwering Anthony Sinn Karen E Pollok Kent A Robertson W Scott Goebel Kerry M Hege | 2020 | World Journal of Stem Cells2020，12，5： | 0 |
| 10 | Double Series Identity and Some Laurent Type Hypergeometric Generating Relations显示文摘The main aim of this article is to obtain certain Laurent type hypergeometric generating relations. Using a general double series identity, Laurent type generating functions(in terms of Kampede Feriet double hypergeometric function) are derived. Some known results obtained by the method of Lie groups and Lie algebras, are also modified here as special cases. | Mohammad Idris QURESHI Mahvish ALI Dilshad AHAMAD | 2020 | Journal of Mathematical Research with Applications2020，40，5： | 0 |
| 11 | Indefinite Least Squares Problem with Quadratic Constraint and Its Condition Numbers显示文摘In this paper,we consider the indefinite least squares problem with quadratic constraint and its condition numbers.The conditions under which the problem has the unique solution are first presented.Then,the normwise,mixed,and componentwise condition numbers for solution and residual of this problem are derived.Numerical example is also provided to illustrate these results. | Mahvish SAMAR Aamir FAROOQ Chunlai MU Iram MUSHTAQ | 2020 | Journal of Mathematical Research with Applications2020，40，1： | 0 |
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