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| 1 | SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir,nirmatrelvir,and the combination显示文摘Dear Editor,Since the first outbreak in late 2019,the RNA genome of SARS-CoV-2 has been undergoing constant evolution.This is largely attributed to the viral polymerase that is intrinsically error prone and the selection pressures exerted by the host immune system.Several variants of concern harboring multiple mutations in the spike protein have emerged in the past year.The currently fast-spreading Omicron variant contains many more mutations compared with the previous variants,and most of these mutations are located around the receptor binding domain of the spike protein. | Pengfei Li Yining Wang Marla Lavrijsen Mart M.Lamers Annemarie C.de Vries Robbert J.Rottier Marco J.Bruno Maikel P.Peppelenbosch Bart L.Haagmans Qiuwei Pan | 2022 | Cell Research2022，32，3： | 11 |
| 2 | Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver显示文摘AIM: To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS: Fifty-four adult male Wistar rats were randomly divided into three groups: A normal control (NC) group, a partial hepatectomized (PH) group and a sham operated (SO) group. To study the effect of liver regeneration on BMP-2 expression, rats were sacrificed before and at different time points after PH or the sham intervention (6, 12, 24 and 48 h). For each time point, six rats were used in parallel. Expression and distribution of BMP-2 protein were determined in regenerating liver tissue by Western blot analysis and immunohistochemistry. Effects of BMP-2 on cell proliferation of human Huh7 hepatoma cell line were assessed using an MTT assay.RESULTS: In the normal liver strong BMP-2 expression was observed around the central and portal veins. The expression of BMP-2 decreased rapidly as measured by both immunohistochemistry and Western blot analysis. This decrease was at a maximum of 3.22 fold after 12 h and returned to normal levels at 48 h after PH. No significant changes in BMP-2 immunoreactivity were observed in the SO group. BMP-2 inhibited serum induced Huh7 cell proliferation.CONCLUSION: BMP-2 is expressed in normal adult rat liver and negatively regulates hepatocyte proliferation. The observed down regulation of BMP-2 following partial hepatectomy suggests that such down regulation may be necessary for hepatocyte proliferation. | Cui-Ping Xu Wen-Min Ji Gijs R van den Brink Maikel P Peppelenbosch | 2006 | World Journal of Gastroenterology2006，12，47： | 10 |
| 3 | Telaprevir/boceprevir era: From bench to bed and back显示文摘Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field. | Maikel P Peppelenbosch Harry LA Janssen Robert J de Knegt | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 4 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 5 | Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function显示文摘 | Henri Braat Esther C. Jong Jan M. H. Brande Martien L. Kapsenberg Maikel P. Peppelenbosch Eric A. F. Tol Sander J. H. Deventer | 2004 | Journal of Molecular Medicine2004，，3： | 1 |
| 6 | Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon显示文摘 | James C.H. Hardwick Gijs R. Van Den Brink Sylvia A. Bleuming Isabel Ballester Jan.M.H. Van Den Brande Josbert J. Keller G.Johan A. Offerhaus Sander J.H. Van Deventer Maikel P. Peppelenbosch | 2004 | Gastroenterology2004，，： | 1 |
| 7 | Leptin Is a Growth Factor for Colonic Epithelial Cells显示文摘 | James C.H. Hardwick Gijs R. Van Den Brink G.J. Offerhaus Sander J.H. Van Deventer Maikel P. Peppelenbosch | 2001 | Gastroenterology2001，，1： | 1 |
| 8 | The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers显示文摘 | Liudmila L. Kodach Eliza Wiercinska Noel F.C.C. de Miranda Sylvia A. Bleuming Alex R. Musler Maikel P. Peppelenbosch Evelien Dekker Gijs R. van den Brink Carel J.M. van Noesel Hans Morreau Daniel W. Hommes Peter ten Dijke G. Johan A. Offerhaus James C.H. | 2008 | Gastroenterology2008，，： | 1 |
| 9 | RF magnetron sputter deposition of transparent conducting Nb-doped TiO2 films on SrTiO3 显示文摘 | MEAGEN A GILLISOIE MAIKEL F A M VAN HEST MATTHEWS DABNEY | 2007 | J Appl Phys2007，101，3： | 1 |
| 10 | Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn’s disease显示文摘 | Jan M.H Van den Brande Henri Braat Gijs R van den Brink Henri H Versteeg Christiaan A Bauer Inge Hoedemaeker Catherine van Montfrans Daan W Hommes Maikel P Peppelenbosch Sander J.H van Deventer | 2003 | Gastroenterology2003，，7： | 1 |
| 11 | Low-cost inorganic solar cells: From ink to printed device 显示文摘 | Susan E Habas Heather A S Platt Maikel F A M | 2010 | Chem Rev2010，110，： | 1 |
| 12 | Neuronal differentiation of embryonic stem cells 显示文摘 | van Maikel PP Maria WM | 1996 | Biochim Biophys Acta1996，1312，： | 1 |
| 13 | A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease显示文摘 | Henri Braat Pieter Rottiers Daniel W. Hommes Nathalie Huyghebaert Erik Remaut Jean–Paul Remon Sander J.H. van Deventer Sabine Neirynck Maikel P. Peppelenbosch Lothar Steidler | 2006 | Clinical Gastroenterology and Hepatology2006，，6： | 1 |
| 14 | Neuronal differentiation of embryonic stem cells显示文摘 | VAN MAIKEL PP MARIA WM | 1996 | Biochim Biophys Acta1996，1312，： | 1 |
| 15 | The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease显示文摘 | J. Jasper Deuring Colin de Haar Ernst J. Kuipers Maikel P. Peppelenbosch C. Janneke van der Woude | 2013 | International Journal of Biochemistry and Cell Biology2013，，4： | 1 |
| 16 | Phosphoprotein levels, MAPK activities and NFκB expression are affected by fisetin显示文摘 | Roberta R. Ruela de Sousa Karla Cristiana Souza Queiroz Ana Carolina Santos Souza Sonia A. Gurgueira Amanda Cavallari Augusto Marcio André Miranda Maikel P. Peppelenbosch Carmen Veríssima Ferreira Hiroshi Aoyama | 2007 | Journal of Enzyme Inhibition and Medicinal Chemistry2007，，4： | 1 |
| 17 | TIR-R concentrator: a new compact high-gain SMS design显示文摘 | Jose L Alvarez Maikel Hemandez Pablo Benitez | 2002 | Proceedings of SPIE2002，4446，： | 1 |
| 18 | Leptin Is a Growth Factor for Colonic Epithelial Cells显示文摘 | James C.H. Hardwick Gijs R. Van Den Brink G.J. Offerhaus Sander J.H. Van Deventer Maikel P. Peppelenbosch | 2001 | Gastroenterology2001，，1： | 1 |
| 19 | T1R-R Concentrator: a new compact high-gain SMS design 显示文摘 | JOSE L A MAIKEL H PABLO B | 2002 | SPIE2002，4446，： | 1 |
| 20 | Inhibition of nonlinear acoustic cavitation dynamics in liquid CO2显示文摘 | Maikel M van Iersel Jeroen Cornel Nieck E Benes | 2007 | The Journal of Chemical Physics2007，126，6： | 1 |
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