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| 1 | Bisphenol A exposure alters release of immune and developmental modulators and expression of estrogen receptors in human fetal lung fibroblasts显示文摘Bisphenol A(BPA) has been shown to exert biological effects through estrogen receptor(ER)-dependent and ER-independent mechanisms. Recent studies suggest that prenatal exposure to BPA may increase the risk of childhood asthma. To investigate the underlying mechanisms in the actions of BPA, human fetal lung fibroblasts(h FLFs) were exposed to varying doses of BPA in culture for 24 hr. Effects of BPA on localization and uptake of BPA,cell viability, release of immune and developmental modulators, cellular localization and expression of ERα, ERβ and G-protein coupled estrogen receptor 30(GPR30), and effects of ERs antagonists on BPA-induced changes in endothelin-1(ET-1) release were examined.BPA at 0.01–100 μmol/L caused no changes in cell viability after 24 hr of exposure. h FLFs expresses all three ERs. BPA had no effects on either cellular distribution or protein expression of ERα, however, at 100 μmol/L(or 23 μmol/L intracellular BPA) increased ERβprotein levels in the cytoplasmic fractions and GPR 30 protein levels in the nuclear fractions.These paralleled with increased release of growth differentiation factor-15, decreased phosphorylation of nuclear factor kappa B p65 at serine 536, and decreased release of ET-1,interleukin-6, and interferon gamma-induced protein 10. ERs antagonists had no effects on BPA-induced decrease in ET-1 release. These data suggest that BPA at 100 μmol/L altered the release of immune and developmental modulators in h FLFs, which may negatively influence fetal lung development, maturation, and susceptibility to environmental stressors, although the role of BPA in childhood asthma remains to be confirmed in in vivo studies. | Laziyan Mahemuti Qixuan Chen Melanie C. Coughlan Min Zhang Maria Florian Ryan J Mailloux Xu-Liang Cao Kylie A. Scoggan William G. Willmore Xiaolei Jin | 2016 | Journal of Environmental Sciences2016，28，10： | 3 |
| 2 | Hypertension in chronic renal failure and ESRD: Prevalence pathophysielogy, and outcomes显示文摘 | Mailloux LU | 2001 | Semin Nephrol2001，21，： | 1 |
| 3 | The tricarboxylic acid cycle,an ancient metabolic network with a novel twist显示文摘 | MAILLOUX R J BERIAULT R LEMIRE J | 2007 | PLoS One2007，2，8： | 1 |
| 4 | Long term exercise adherence in the elderly with chronic low back pain显示文摘 | Mailloux J Finno M Ranville J | | 0，，： | 1 |
| 5 | Grating lobe control in limitedscan array 显示文摘 | Robert J Mailloux Lore Zahn | 1979 | IEEE Transactions on Antennas and Propa-gation1979，27，1： | 1 |
| 6 | Phased Array Theory and Technology显示文摘 | Mailloux R J | 2005 | Proceed- ings of the IEEE2005，70，3： | 1 |
| 7 | Influ- ence of ground cover management on diversity and density of phytoseiid mites (Acari: Phytoseiidae) in Guadeloupean citrus orchards显示文摘 | Mailloux J Le Bellee F Kreiter S | 2010 | Experimental and Applied Acarology2010，52，3： | 1 |
| 8 | Proteomic study of human umbilical vein endothelial ceils in culture显示文摘 | BRUNEEL A LABAS V MAILLOUX A | 2003 | Proteomics2003，3，5： | 1 |
| 9 | Uncoupling proteins and the control of mitochondrial reactive oxygen species production显示文摘 | Ryan J. Mailloux Mary-Ellen Harper | 2011 | Free Radical Biology and Medicine2011，，： | 1 |
| 10 | Renal vascular disease causing end stage renal disease,incidence,clinical correlates,and outcomes:a 20 year clinical experience显示文摘 | Mailloux L Napolitano B Bellucci AG Vernace M Wilkes BM Mossey RT | 1994 | Am J Kidney Dis1994，24，： | 1 |
| 11 | Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometniosis显示文摘 | Collette T Maheux R Mailloux J | | 0，，12： | 1 |
| 12 | Covariance matrix augmentation to produce adaptive array pattern troughs显示文摘 | MAILLOUX R J | 1995 | Electroncs Letters1995，31，10： | 1 |
| 13 | Array grating lobes due to periodic phase, amplitude, and time delay quantization显示文摘 | Mailloux Robert J | 1984 | IEEE Transaction on Antennas and Propagation1984，32，12： | 1 |
| 14 | Using The Essentials of Baccalaureate Educa- tion for Professional Nursing Practice(2008) as a Framework for Curriculum Revision显示文摘 | Mailloux C G | 2011 | J Prof Nurs2011，27，6： | 1 |
| 15 | Covariance matrix augmentation to produce adaptive array pattern troughs显示文摘 | Mailloux R J | 1995 | Electronics Letters1995，31，10： | 1 |
| 16 | Predictors of survival in patients undergoing dialysis显示文摘 | Mailloux L U Bellucci A G Mossey R T | 1988 | Am J Med1988，84，： | 1 |
| 17 | Acute renal failure: Pathogenesis and prevention显示文摘 | Wilkes BM Mailloux LU | 1986 | Am J Med1986，80，： | 1 |
| 18 | Covariance matrix augmention to produce adaptive array pattern troughs显示文摘 | Mailloux R J | 1995 | Electronics Letters1995，31，10： | 1 |
| 19 | GABAB receptor stimulation decreases amphetamine - induced behavior and neuropeptide gene expression in the striatnm显示文摘 | Zhou W Mailloux AW Jung B J | 2004 | Brain Res2004，1004，12： | 1 |
| 20 | NALPI in vitiligo-associated muhiple autoimmune disease 显示文摘 | Jin Y Mailloux CM Gowan K | 2007 | N Engl J Med2007，356，12： | 1 |
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