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160篇 您的检索式:作者名="Mal A"
    题名 作者 年代 出处 被引量
1Efficacy of bevacizumab-containing chemotherapy in metastatic colorectal cancer and CXCL5 expression: Six case reports显示文摘BACKGROUND In metastatic colorectal cancer(mCRC),the anti-vascular endothelial growth factor drug bevacizumab(BVZ)plus chemotherapy significantly improves progression-free survival compared to chemotherapy(CT)alone.This benefit is not,however,observed in all patients.While increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker,few studies have examined its relationship with drug efficacy.This study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to treatment.CASE SUMMARY We report six cases of stage IV KRAS-mutated mCRC.Patients were given first line treatment with BVZ-containing chemotherapy in University Hospital of Fuenlabrada.The six patients differed in terms of primary tumor location(right/left side),tumor burden(mostly hepatic and peritoneal disease)and clinical disease course.Before treatment onset,total RNA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR procedures.Our main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival(under 6 mo)from the start of treatment.CONCLUSION A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment.Apolonia Novillo María Gaibar Alicia Romero-Lorca María Fuencisla Gilsanz Laura Beltrán Miguel Galán Beatriz Antón Diego Malón Amalia Moreno Ana Fernández-Santander 2020World Journal of Gastroenterology2020,26,16:2
2Characterization of composite laminates using combined LLW and PBS methods 显示文摘Bar-Cohen Y Mal A K 1991Springer US1991,,:1
3Identification of critical erosion prone areas in the small agricultural watershed using USLE, GIS and remote sensing 显示文摘A PANDEY V M CHOWDARY B C MAL 2007Water Resources Management2007,21,4:1
4Runoffand sediment yield modeling from a small agriculturalwatershed in India using the WEPP model显示文摘PANDEY A CHOWDARY V M MAL B C 2008Journal ofHydrology2008,348,34:1
5查看详情显示文摘Sasidharan M Mal N K Bhaumik A 0,,03:1
6Immediate loading of implants placed in patients with untreated periodontal disease: A 5-year prospective cohort study显示文摘Mal 6 P Nobre Mde A Lopes A 2014Eur J Oral Implantol2014,7,3:1
7Monoeyte ehemotactic protein-3 is amyocardial mesenchymal stem eell homing faetor 显示文摘Sehenk S Mal N Finan A 2007Stem Cells2007,25,1:1
8Monocyte chemotactic protein- 3 is a myocardial mesenchymal stem cell homing factor 显示文摘Schenk S Mal N Finan A 2007Stem Cells2007,25,1:1
9Effect of copper on growth of an aquatic macrophyte, Elodea canadensis 显示文摘MAL T K ADORJAN P CORBETT A L 2002Environ Pollut2002,120,2:1
10Response of okra to dripirrigation under mulch and non-mulch conditions显示文摘Tiwari K N Mal P K Singh R M Chattopadhyay A 1998Agricultural Water Management1998,38,2:1
11A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD:inhibition of the myogenic program显示文摘Mal A Stumiolo M Schiltz L 2001EMBO J2001,20,7:1
12Inactivation of p27 kip 1 by the viral E1A oncoprotein in TGF β-treated cells 显示文摘 Poon RY Howe PH 1996Nature1996,380,6571:1
13On the gelation rates of thermoreversible poly (vinylidene fluoride) gels 显示文摘Mal S Maiti P Nandi A K 1995Macromolccules1995,28,7:1
14Microporous niobium phosphates and catalytic properties prepared by a supramolecular templating mechanism显示文摘Mal N K Bhaumik A Kumar P 2003Chem Commun2003,,7:1
15Remote sensing and GIS for identification of suitable sites for soil and water conservation structures 显示文摘Pandey A Chowdary V M Mal B C 2011Land Degradation & Development2011,22,3:1
16Catheter associated urinary tract infections in neurology and neurosurgical units显示文摘Puri J Mishra B Mal A 2002J Infect2002,44,3:1
17Application of the WEPP model for prioritization andevaluation of best management practices in an Indianwatershed显示文摘PANDEY A CHOWDAY V M MAL B C 2009Hydrological Processes2009,23,21:1
18Catheter associated urinary tract infec tion inneurology and neurosurgicalunits显示文摘Puri J Mishra B Mal A 2002J Infect2002,44,3:1
19Non-isothermal simulation of the resin transfer moulding process显示文摘Mal O Couniot A Dupret F 1998Composites: Part A1998,29,12:1
20Yield and quality of bush processing tomatoes fertilized with dried organic and organomineral fertilizers显示文摘BO(C)EK S MAL(Y) I PATO(C)KOV(A) (S) 0,,02:1
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