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| 1 | Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis显示文摘AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome(DIOS) in Israeli cystic fibrosis(CF) patients.METHODS: This is a multi-center,comparative,retrospective study in which we reviewed the medical records of all CF patients from three major CF centers in Israel who were treated in the period from 1980 to 2012.Patients diagnosed with DIOS were defined as the study group.The patients were diagnosed with DIOS based on their clinical presentation and typical findings on either abdominal X-ray or computerized tomography scan.For the control group,CF patients with no DIOS were matched to the patients in the study group for age,sex,and cystic fibrosis transmembrane conductance regulator(CFTR) mutations.For both groups,the collected data included age,sex,CFTR genotype,weight,height,and body mass index.Clinical data included respiratory function tests in the last five years prior to the study,respiratory function test immediately before and after the DIOS event,number of hospitalizations,sputum culture results,and CFrelated conditions diagnosed according to the CF clinical practice guidelines.In the study group,data on the DIOS treatment and tendency for DIOS recurrence were also analyzed.RESULTS: The medical charts for a total of 350 CF patients were reviewed.Of the 350 CF patients,26(7.4%) were diagnosed with DIOS.The control group included 31 CF patients with no DIOS diagnosis.The mean follow-up period was 21.6 ± 8.2 years.The total of DIOS episodes in the follow-up period was 60.The distribution of DIOS episodes was as follows: 6/26(23.1%) study patients had one episode of DIOS intheir lifetime,7/26(26.9%) had two episodes,7/26(26.9%) had three episodes,and 6/26(23.1%) had four or more episodes.Compared to the control group,DIOS patients had a significantly higher incidence of meconium ileus in the past(65.4% vs 0%,respectively,P < 0.02),more Aspergillus spp.colonization(34.6% vs 3.2%,respectively,P < 0.02),and a higher number of hospitalizations due to respiratory exacerbations(8.6 vs 6.2 mean total hospitalizations per follow-up period,respectively,P < 0.02).No other significant differences were found between the control and study groups.The conservative treatment of DIOS,which mainly includes hydration and stool softeners,was successful in 82% of the episodes.The survival rate was similar for both groups.CONCLUSION: CF patients with DIOS suffer from recurrent hospitalizations and airway pathogen acquisition.Although recurrence of DIOS is common,conservative treatment is successful in most patients. | Moran Lavie Tzipora Manovitz Daphna Vilozni Sarina Levy-Mendelovich Ifat Sarouk Ilana Weintraubv David Shoseyov Malena Cohen-Cymberknoh Joseph Rivlin Ori Efrati | 2015 | World Journal of Gastroenterology2015，21，1： | 10 |
| 2 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 3 | Meta-analysis of diagnostic procedures for Pneumocystis cariniipneumonia in HIV-l-infected patients显示文摘 | Cruciani M Marcati P Malena M | 2002 | Eur Respir J2002，20，4： | 1 |
| 4 | 新生儿肺动静脉畸形的早期神经系统并发症:手术切除的一项指征显示文摘A case report of a neonate with pulmonary arteriovenous malformation is described. The anomaly was prenatally diagnosed,and family history was positive for Rendu-Osler-Weber syndrome. Because neurologic symptoms developed during the second week of life,surgical resection was deemed the best curative option to avoid further embolic events and reoccurrence of the lesion. Previous reports detailing coil embolization therapy for pulmonary arteriovenous malformation are discussed. | Borsellino A. Giorlandino C. Malena S. 刘凯 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，9： | 1 |
| 5 | Antifungal prophylaxis in liver transplant patients:a systematic review and meta-analysis显示文摘 | Cruciani M Mengoli C Malena M | 2006 | Liver Transpl2006，12，5： | 1 |
| 6 | 18 F-Fluorodeoxyglucose-PET/CT Imaging of Lungs in Patients With Cystic Fibrosis显示文摘 | Martine Klein Malena Cohen-Cymberknoh Shoshana Armoni David Shoseyov Roland Chisin Marina Orevi Nanette Freedman Eitan Kerem | 2009 | Chest2009，，： | 1 |
| 7 | Inhibition of mitochondrial fi ssion favours mutant over wild-type mitochondrial DNA 显示文摘 | Malena A Loro E Di RM | 2009 | Hum Mol Genet2009，18，18： | 1 |
| 8 | The logic of innovation in construc- tion显示文摘 | LENA E B MALENA I | 2014 | Industrial Marketing Management2014，43，3： | 1 |
| 9 | Motor function following multilevel botulinum toxin type A treatment in children with cerebral palsy 显示文摘 | Desloovere K Malenaers G De Cat J | 2007 | Dev Med Child Neurol2007，49，1： | 1 |
| 10 | Meta-analysis of diagnos- tic procedures for Pneumocystis carinii pneumonia in HIV-Ⅰ-in- fected patients显示文摘 | Cruciani M Marcati P Malena M | 2002 | Eur Respir J2002，20，4： | 1 |
| 11 | Obesity and excessMort ality among the elderly in the United States and Mexico显示文摘 | Malena Monteverde Kenya Noronha Alberto Pallon | 2010 | Demography2010，，： | 1 |
| 12 | Fuel emulsions and microemulsions based on Fischer–Tropsch diesel显示文摘 | Anna Lif Malena Stark Magnus Nydén Krister Holmberg | 2009 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2009，，1： | 1 |
| 13 | IGS sequence variation,group-I introns and complete nuclear ribosomal DNA of the entomopathogenic fungus Metarhizium excellent tools for isolate detection and phylogenetic analysis显示文摘 | MALENA P P AMMOULA M MILTON A T | 2003 | Fungal Genetics and Biology2003，38，2： | 1 |
| 14 | Meta-analysis of BACTEC MGIT 960 and BACTEC 460 TB, with or without solid media, for detection of mycobacteria显示文摘 | Cruciani M Scarparo C Malena M | 2004 | J Clin Microbi- ol2004，42，5： | 1 |
| 15 | Meta-analysis of BACTECMGIT 960and BACTEC 460TB,with or without solid media,for detection og mycobacteria显示文摘 | Cruciani M Scarparo C Malena M | 2004 | J Clin Microbiol2004，42，5： | 1 |
| 16 | Global impoverishment, sustainable development and the environment-A conceptual approach 显示文摘 | Gallopin G C Gutman P Malena H | 1989 | International Social Science Journal1989，121，： | 1 |
| 17 | Obesity and excess mortality among the elderly in the United States and Mexico显示文摘 | Malena Monteverde Kenya Noronha Alberto Palloni | 2010 | Demography2010，47，1： | 1 |
| 18 | Meta analysis of BACTEC MGIT 960 and BACTEC 460 TB,with or without sol- id media, for detection of mycobacteria 显示文摘 | Cruciani M Scarparo C Malena M | 2004 | J Clin Microbiol2004，42，： | 1 |
| 19 | Meta-analysis of BACTEC MGIT 960 and BACTEC 460 TB, with or without sol id media, for detection of mycobacteria 显示文摘 | Cruciani M Scarparo C Malena M | 2004 | J Clinical Microbiol ogy2004，42，5： | 1 |
| 20 | Antifungal prophylaxis in liver transplant patients:a systematic review and meta-analysis显示文摘 | Cruciani M Mengoli C Malena M | 2006 | Liver Transpl2006，12，5： | 1 |
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