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| 1 | Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering显示文摘Vascular grafts must avoid negative inflammatory responses and thrombogenesis to prohibit fibrotic deposition immediately upon implantation and promote the regeneration of small diameter blood vessels(<6 mm inner diameter).Here,polyurethane(PU)elastomers incorporating anti-coagulative and anti-inflammatory Gastrodin were fabricated.The films had inter-connected pores with porosities equal to or greater than 86%and pore sizes ranging from 250 to 400μm.Incorporation of Gastrodin into PU films resulted in desirable mechanical properties,hydrophilicity,swelling ratios and degradation rates without collapse.The released Gastrodin maintained bioactivity over 21 days as assessed by its anti-oxidative capability.The Gastrodin/PU had better anti-coagulation response(less observable BSA,fibrinogen and platelet adhesion/activation and suppressed clotting in whole blood).Red blood cell compatibility,measured by hemolysis,was greatly improved with 2Gastrodin/PU compared to other Gastrodin/PU groups.Notably,Gastrodin/PU upregulated anti-oxidant factors Nrf2 and HO-1 expression in H2O2 treated HUVECs,correlated with decreasing pro-inflammatory cytokines TNF-αand IL-1β in RAW 264.7 cells.Upon implantation in a subcutaneous pocket,PU was encapsulated by an obvious fibrous capsule,concurrent with a large amount of inflammatory cell infiltration,while Gastrodin/PU induced a thinner fibrous capsule,especially 2Gastrodin/PU.Further,enhanced adhesion and proliferation of HUVECs seeded onto films in vitro demonstrated that 2Gastrodin/PU could help cell recruitment,as evidenced by rapid host cell infiltration and substantial blood vessel formation in vivo.These results indicate that 2Gastrodin/PU has the potential to facilitate blood vessel regeneration,thus providing new insight into the development of clinically effective vascular grafts. | Meng Zheng Jiazhi Guo Qing Li Jian Yang Yi Han Hongcai Yang Mali Yu Lianmei Zhong Di Lu Limei Li Lin Sun | 2021 | Bioactive Materials2021，6，2： | 7 |
| 2 | Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration显示文摘The development of functional materials for osteoporosis is ultimately required for bone remodeling.However,grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone formation.In this work,nano-hydroxyapatite(n-HA)/resveratrol(Res)/chitosan(CS)composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of Res.Study of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res release.Notably,microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α,IL-1βand iNOS in RAW264.7 cells in a dose dependent manner.Further,enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell growth.The ability to enhance osteo-differentiation was supported by up-regulation of Runx2,ALP,Col-1 and OCN,and substantial mineralization in osteogenic medium.When implanted into bone defects in the osteoporotic rat femoral condyles,enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture healing.The results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment. | Limei Li Mali Yu Yao Li Qing Li Hongcai Yang Meng Zheng Yi Han Di Lu Sheng Lu Li Gui | 2021 | Bioactive Materials2021，6，5： | 6 |
| 3 | 在英语课文教学中提问与回答的作用(英文)显示文摘激发性和探测性的课堂提问能加强学生的课堂学习,能使以前被动学习的学生积极投入,同时能使教师了解和把握学生的技能水平,从而做到因材施教。本文通过对医学专业研究生英语学习现状的分析,介绍本人在大学英语课文教学中所使用的方法。在课文教学课堂上,本人提出很多有关课文教学不同阶段的问题,让学生回答。它们包括:课文前热身问题,限时阅读理解问题,有关词与句的问题以及课文分析问题。这些问题能刺激学生积极思维,训练学生口语交际能力并加强学生分析,概括和推理的语言交际能力。 | Kong Mali Xinjiang Medical University Li Li Shandong Cadre Institute of Economics Management | 2002 | Chinese Journal of Applied Linguistics2002，25，1： | 4 |
| 4 | Dual-wavelength bidirectional pumped high-power Raman fiber laser显示文摘In this paper, we reported both the experimental demonstration and theoretical analysis of a Raman fiber laser based on a master oscillator–power amplifier configuration. The Raman fiber laser adopted the dual-wavelength bidirectional pumping configuration, utilizing 976 nm laser diodes and 1018 nm fiber lasers as the pump sources. A 60-m-long25/400 μm ytterbium-doped fiber was used to convert the power from 1070 to 1124 nm, realizing a maximum power output of 3.7 kW with a 3 dB spectral width of 6.8 nm. Moreover, we developed a multi-frequency model taking into consideration the Raman gain spectrum and amplified spontaneous emission. The calculated spectral broadening of both the forward and backward laser was in good agreement with the experimental results. Finally, a 1.5 kW, 1183 nm second-order Raman fiber laser was further experimentally demonstrated by the addition of a 70-m-long germaniumdoped passive fiber. | Zehui Wang Qirong Xiao Yusheng Huang Jiading Tian Dan Li Ping Yan Mali Gong | 2019 | High Power Laser Science and Engineering2019，7，1： | 4 |
| 5 | Recent advances in FIB–TEM specimen preparation techniques 显示文摘 | LI J MALIS T DIONNE S | 2006 | Materials Characterization2006，57，1： | 1 |
| 6 | Preventive superficial plexus block for postoperative cervicocephalic pain in neurosurgery显示文摘 | Nijima K Malis LI | 1993 | Neurol Med Chit1993，33，： | 1 |
| 7 | Nuances in acoustic neuroma surgery 显示文摘 | Malis LI | 2001 | Neurosurgery2001，49，2： | 1 |
| 8 | The dispersive properties of a dielectric rod loaded waveguide immersed in a magnetized annular plasma显示文摘 | LI Wei GONG Mali WEI Yanyu | 2004 | Chin Phys Lett2004，13，1： | 1 |
| 9 | Preventive superficial cervical plexus block for postoperative cervicocephalic pain in neurosurgery 显示文摘 | Niijima K Malis LI | 1993 | Neurol Med Chir (Tokyo)1993，33，6： | 1 |
| 10 | Nuances in acoustic neuroma surgery显示文摘 | | 2001 | Neurosurgery2001，49，2： | 1 |
| 11 | Nuances in acoustic neuroma surgery 显示文摘 | Malis LI | 2001 | Neurosurgery2001，49，2： | 1 |
| 12 | The myelographic examination of the foramen magnum 显示文摘 | Malis LI | 1958 | Radiology1958，70，2： | 1 |
| 13 | Preventive superficial plexus block for postoperative cervicocephalic pain in neurosurgery显示文摘 | Nijima K Malis LI | 1993 | Neurol Med Chir1993，33，： | 1 |
| 14 | Numerical modeling of transverse mode competition in strongly pumped multimode fiber lasers and amplifiers显示文摘 | Gong Mali Yuan Yanyang Li Chen | 2007 | Optics Express2007，15，6： | 1 |
| 15 | Nuances in acoustic neuroma surgery 显示文摘 | Malis LI | 2001 | Neurosurgery2001，49，2： | 1 |
| 16 | Nuances in acoustic neuroma surgery 显示文摘 | Malis LI | 2001 | Neurosurgery2001，49，2： | 1 |
| 17 | Preventive superficial plexus block for post-operative cervecocephalic pain in neurosurgery 显示文摘 | Niijima K Malis LI | 1993 | Neurol Med Chit1993，33，6： | 1 |
| 18 | Nuances in acoustic neuroma surgery显示文摘 | Malis LI | 2001 | Neurosurgery2001，49，2： | 1 |
| 19 | Recent advances in FIB- TEM specimen preparation techniques 显示文摘 | Li J Malis T Dionne S | 2006 | Materials characterization2006，57，1： | 1 |
| 20 | Human CMV transcripts: an overview显示文摘 | Ma Yanping Wang Ning Li Mali Gao Shuang Wang Lin Zheng Bo Qi Ying Ruan Qiang | 2012 | Future Microbiology2012，，5： | 1 |
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