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| 1 | New level-3 opioids of the world health organization显示文摘 | Lanai G Sang B Mallaret M | 2002 | Rev Med lnterte2002，，： | 1 |
| 2 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 3 | New Level Ⅲ opioids of the World Health Organization显示文摘 | Laval G Sang B Mallaret M | | 0，，1： | 1 |
| 4 | Nefopam abuse显示文摘 | Villier C Mallaret MP | 2002 | Ann Pharmacother2002，36，10： | 1 |
| 5 | New Level lII opioids of the World Health Organization显示文摘 | Laval G Sang B Mallaret M | 2002 | Rev Med Interne2002，23，1： | 1 |
| 6 | A neonatal specialist with recur- rent methicillinresistant Staphylococcus aureus (MRSA) carriage implicated in the transmission of MRSA to newborns 显示文摘 | Mean M Mallaret MR Andrini P | 2007 | Infect Control Hosp Epidemiol2007，28，5： | 1 |
| 7 | New Level - 3 opioids of the world health organization显示文摘 | Laval G Sang B Mallaret M | 2002 | Rev Med Interne2002，23，1： | 1 |
| 8 | New Level IH opioids ofthe World Health Organization显示文摘 | Laval G Sang B Mallaret M | 2002 | Rev Med Interne2002，23，1： | 1 |
| 9 | 自动内镜洗涤器/消毒器出现故障后在无清洁剂的情况下胃肠内镜尚清洁 | Méan M. Mallaret M.R. Bichard P. 纪泛扑 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，11： | 0 |
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