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| 1 | Evolution of blood lipids and risk factors of dyslipidemia among people living with human immunodeficiency virus who had received first-line antiretroviral regimens for 3 years in Shenzhen显示文摘Background:Lipid abnormalities are prevalent among people living with human immunodeficiency virus(HIV)(PLWH)and contribute to increasing risk of cardiovascular events.This study aims to investigate the incidence of dyslipidemia and its risk factors in PLWH after receiving different first-line free antiretroviral regimens.Methods:PLWH who sought care at the Third People’s Hospital of Shenzhen from January 2014 to December 2018 were included,and the baseline characteristics and clinical data during the follow-up were collected,including total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C).The risk factors of dyslipidemia after antiretroviral therapy were analyzed with the generalized estimating equation model.Results:Among the 7623 PLWH included,the mean levels of TC,HDL-C and LDL-C were 4.23±0.85 mmol/L,1.27±0.29 mmol/L and 2.54±0.65 mmol/L,respectively,and the median TG was 1.17(IQR:0.85-1.68)mmol/L.Compared with that in PLWH receiving tenofovir disoproxil fumarate(TDF)+lamivudine(3TC)+ritonavir-boosted lopinavir(LPV/r),zidovudine(AZT)+3TC+efavirenz(EFV),and AZT+3TC+LPV/r,the incidence of dyslipidemia was lower in PLWH receiving TDF+3TC+EFV.In multivariate analysis,we found that the risks of elevations of TG,TC,and LDL-C were higher with TDF+3TC+LPV/r(TG:odds ratio[OR]=2.82,95%confidence interval[CI]:2.55-3.11,P<0.001;TC:OR=1.24,95%CI:1.14-1.35,P<0.001;LDL:OR=1.06,95%CI:1.00-1.12,P=0.041),AZT+3TC+EFV(TG:OR=1.41,95%CI:1.28-1.55,P<0.001;TC:OR=1.43,95%CI:1.31-1.56,P<0.001;LDL:OR=1.18,95%CI:1.12-1.25,P<0.001),and AZT+3TC+LPV/r(TG:OR=3.08,95%CI:2.65-3.59,P<0.001;TC:OR=2.40,95%CI:1.96-2.94,P<0.001;LDL:OR=1.52,95%CI:1.37-1.69,P<0.001)than with TDF+3TC+EFV,while treatment with TDF+3TC+LPV/r was less likely to restore HDL-C levels compared with TDF+3TC+EFV(OR=0.95,95%CI:0.92-0.97,P<0.001).In addition to antiretroviral regimens,antiretroviral therapy duration,older age,overweight,obesity and other traditional factors were also important risk factors for dyslipidemia.Conclusion:The incidence of dyslipidemia varies with different antiretroviral regimens,with TDF+3TC+EFV having lower risk for dyslipidemia than the other first-line free antiretroviral regimens in China. | Li-Qin Sun Jia-Ye Liu Yun He Yang Zhou Liu-Mei Xu Lu-Kun Zhang Fang Zhao Xiao-Ning Liu Ying Song Ting-Zhi Cao Yi-Mei Tian Man Rao Hui Wang | 2020 | Chinese Medical Journal2020，，23： | 9 |
| 2 | Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer显示文摘Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin(DOX) and Toll-like receptor 7 agonist imiquimod(IMQ) in low molecular weight heparin(LMWH)-D-α-tocopheryl succinate(TOS) micelles(LT). In this process, LMWH and TOS were conjugated by ester bond and they were not only served as the hydrophilic and hydrophobic segments of the carrier, but also exhibited strong anti-metastasis effect. The direct killing of tumor cells mediated by DOX-loaded micelles(LT-DOX)generated tumor-associated antigens, initiating tumor-specific immune responses in combination with IMQ-loaded micelles(LT-IMQ). Furthermore, the blockade of immune checkpoint with programmed cell death ligand 1(PD-L1) antibody further elevated the immune responses by up-regulating the maturation of DCs as well as the ratios of CD8+ CTLs/Treg and CD4+ Teff/Treg. Therefore, such a multifunctional strategy exhibited great potential for inhibiting the growth of orthotopic and metastatic breast cancer. | Jiaojie Wei Yang Long Rong Guo Xinlei Liu Xian Tang Jingdong Rao Sheng Yin Zhirong Zhang Man Li Qin He | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 3 | Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity显示文摘Dear Editor,Pancreatic cancer (PCa) is a high-grade gastrointestinal malignancy more commonly occurring in elderly populations with lower than 5% overall 5-year survival rate (Hidalgo, 2010). PCa responds poorly to most chemotherapeutic agents, and therefore it is imperative to develop novel therapeutic agents that have anti-cancer activities against PCa. | Juanjuan Feng Mingjin Rao Man Wang Lin Liang Zhi Chen Xiufeng Pang Weiqiang Lu Zhenliang Sun | 2019 | Science China(Life Sciences)2019，62，10： | 6 |
| 4 | Risk factors for de novo hepatitis B infection in pediatric living donor liver transplantation显示文摘AIM: To investigate the incidence of de novo hepatitis B virus(HBV) infection after pediatric living donor liver transplantation(LDLT) and to analyze the risk factors associated with this de novo HBV infection. METHODS: The clinical and laboratory data of children who underwent LDLT from June 2010 to September 2012 in First Center Hospital in Tianjin, China, were retrospectively included in the study. Intrahepatic HBV DNA in donors and recipients was quantified by realtime polymerase chain reaction using DNA extracted from formalin-fixed, paraffin-embedded tissues. RESULTS: Between June 2010 to September 2012, 32 consecutive pediatric patients underwent LDLT in our institute. Thirty LDLT patients(13 girls and 17 boys) were followed up for a median of 15 mo, of whom 53.3%(16/30) were hepatitis B core antibody(HBcAb) positive and 36.7%(11/30) were hepatitis B surface antibody(HBsAb)/HBcAb positive before transplantation. Sixteen of the children received HBcAb-positive allografts, and 43.7%(7/16) of the grafts were found to be intrahepatic HBV DNA positive. De novo HBV infection developed in 16.1%(5/30) of the children within a median of 11 mo after transplantation. All five of the HBV-infected children had received HBcAb-positive allografts, four of which were intrahepatic HBV DNA positive. Two of the children developed de novo HBV infection despite the preoperative presence of both HBsAb and HBcAb CONCLUSION: In pediatric recipients, positive intrahepatic HBV DNA in allografts could be a risk factor for de novo HBV infection from HBcAb-positive allografts. HBsAb/HBcAb positivity in pediatric LDLT patients before transplantation exhibited only weak effectiveness in protecting them against de novo HBV infection from HBcAb-positive allografts. | Wei Rao Man Xie Tao Yang Jian-Jun Zhang Wei Gao Yong-Lin Deng Hong Zheng Cheng Pan Yi-He Liu Zhong-Yang Shen | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 5 | Nerve growth factor-basic fibroblast growth factor poly-lactide co-glycolid sustained-release microspheres and the small gap sleeve bridging technique to repair peripheral nerve injury显示文摘We previously prepared nerve growth factor poly-lactide co-glycolid sustained-release microspheres to treat rat sciatic nerve injury using the small gap sleeve technique.Multiple growth factors play a synergistic role in promoting the repair of peripheral nerve injury;as a result,in this study,we added basic fibroblast growth factors to the microspheres to further promote nerve regeneration.First,in an in vitro biomimetic microenvironment,we developed and used a drug screening biomimetic microfluidic chip to screen the optimal combination of nerve growth factor/basic fibroblast growth factor to promote the regeneration of Schwann cells.We found that 22.56 ng/mL nerve growth factor combined with 4.29 ng/mL basic fibroblast growth factor exhibited optimal effects on the proliferation of primary rat Schwann cells.The successfully prepared nerve growth factor-basic fibroblast growth factor-poly-lactide-co-glycolid sustained-release microspheres were used to treat rat sciatic nerve transection injury using the small gap sleeve bridge technique.Compared with epithelium sutures and small gap sleeve bridging alone,the small gap sleeve bridging technique combined with drug-free sustained-release microspheres has a stronger effect on rat sciatic nerve transfection injury repair at the structural and functional level. | Ming Li Ting-Min Xu Dian-Ying Zhang Xiao-Meng Zhang Feng Rao Si-Zheng Zhan Man Ma Chen Xiong Xiao-Feng Chen Yan-Hua Wang | 2023 | Neural Regeneration Research2023，18，1： | 1 |
| 6 | Influence of ultrasound on diffusion through skin/ leather matrix 显示文摘 | VENKATASUBRAMANIAN Sivakumar GOPALARA- MAN Swaminathan PARUCHURI Gangadhar Rao | 2008 | Chemical Engineering and Processing2008，，47： | 1 |
| 7 | In hibitory effects of praeruptorin-c on cattle aortic smooth mus ele cell proliferation 显示文摘 | WEI EN HUI RAO MAN REN CHEN XIN YING | 2002 | Aeta Pharmacol Sin2002，23，2： | 1 |
| 8 | Low rate of pre-exposure prophylaxis and post-exposure prophylaxis uptake and high prevalence of transmitted drug resistance among newly diagnosed primary HIV infections in Shenzhen, China: a real-world retrospective study显示文摘Background: Understanding the characteristics of newly diagnosed primary human deficiency virus-1 (HIV-1) infection in the context of the post-antiretroviral therapy era and HIV drug prophylaxis is essential for achieving the new target of 95-95-95-95 by 2025. This study reported the characteristics of newly diagnosed primary HIV-1 infection in Shenzhen.Methods: This is a real-world retrospective study. Eighty-seven newly diagnosed primary HIV-1-infected patients were recruited from January 2021 to March 2022 at the Third People’s Hospital of Shenzhen. Demographic, epidemiological, diagnostic, drug resistance, and medical data were described and analyzed.Results: Overall, 96.6% (84/87) of the newly identified primary HIV-1-infected patients were male, including 88.5% (77/87) men have sex with men (MSM), with a median age of 29.0 years (Q_(1)-Q_(3): 24.0-34.0 years);of these, 85.1% (74/87) reported high-risk sexual behaviors with casual partners. The rate of condom usage was only 28.7% (25/87). The overall rate of pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) was 8.0% (7/87, including 4 PrEP and 3 PEP cases) around the potential exposure, although 41.4% of the patients had prior awareness of such interventions. Moreover, only 19.5% (17/87) had previously used PrEP or PEP. Of those, 58.8% (10/17) of the patients obtained drugs from the internet, and only 35.3% (6/17) reported good compliance. A total of 54.0% (47/87) of subjects were diagnosed by the HIV nucleic acid test. Acute retroviral syndrome appeared in 54.0% (47/87) of patients. The prevalence of transmitted drug resistance (TDR) mutation was 33.9% (19/56), including 6 (10.7%) against nucleoside reverse transcriptase inhibitor (NRTI) plus non-nucleoside reverse transcriptase inhibitor (NNRTI), 8 (14.3%) against NNRTI, and 5 (8.9%) against protease inhibitor (PI) only.Conclusions: Owing to the low utilization rate and incorrect usage of PrEP and PEP, massive efforts are needed to promote HIV-preventive strategies in the MSM population. The extremely high prevalence of TDR mutation in this population implies the need for future pretreatment drug resistance surveillance. | Qiaoli Peng Xiaoning Liu Xian Tang Qiuyue Zhang Jin Zhao Chenli Zheng Fang Zhao Yang Zhou Lukun Zhang Liqin Sun Haitao Zhang Xinyun Jia Ying Song Tingzhi Cao Siyuan Wang Man Rao Zhiwei Chen Hui Wang Yun He | 2022 | Chinese Medical Journal2022，135，22： | 1 |
| 9 | Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor显示文摘 | Rao CV Indranie C Simi B Manning PT | 2002 | Cancer Res2002，62，1： | 1 |
| 10 | Successful withdrawal of antiviral treatment in two HBV-related liver transplant recipients after hepatitis B vaccination with long-term follow-up显示文摘To the Editor:Hepatitis B immunoglobulin(HBIG)combined with nucleos(t)ide analogues(NAs)has become the standard regimen for preventing recurrence of hepatitis B virus(HBV)infection in HBV-related liver transplant(LT)recipients. | Man Xie Yun-Jin Zang Bei Zhang Wei Rao | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，6： | 0 |
| 11 | Both APRI and FIB‐4 could effectively evaluate liver fibrosis in liver transplantation recipients显示文摘To the Editor,Liver transplantation(LT)is the only curative therapy for patients with end‐stage liver disease.1 Due to the high incidence of metabolic syndrome after LT,nonalcoholic fatty liver disease(NAFLD)has gradually become an essential cause of post‐LT fibrosis.2 Liver fibrosis can progress to liver cirrhosis and carries the risk of developing hepatocellular carcinoma(HCC),which adversely affects long‐term survival after LT.3,4 Early detection and active intervention for liver fibrosis after LT are crucial in LT recipients.Previous studies have confirmed that transient elastography(TE)could accurately detect liver fibrosis in LT recipients by comparing TE with liver biopsy. | Xiao‐han Fang Man Xie Youwei Zhao Qun Zhang Qiu‐ju Tian Liu Zhao Hong Liu Wei Rao Xinjuan Kong | 2022 | Portal Hypertension & Cirrhosis2022，1，3： | 0 |
| 12 | De novo multiple primary carcinomas in a patient after liver transplantation:A case report显示文摘BACKGROUND Liver transplantation(LT)is the most effective treatment strategy for advanced liver diseases.With the increasing survival rate and prolonged survival time,the postoperative long-term complications of LT recipients are becoming an important concern.Among them,the newly developed cancer after LT is the second complication and cause of LT-related death after cardiovascular disease.At present,few papers have reported multiple primary carcinomas(MPCs)after LT.Herein,we retrospectively analyzed an MPC case with gastric cancer and lung cancer after LT.CASE SUMMARY Herein,we retrospectively analyzed an MPC case with de novo gastric cancer and lung cancer after LT with no obvious complaints.Forty-one months after LT,the patient underwent radical distal gastrectomy(Billroth II)for intramucosal signet ring cell carcinoma,and then thoracoscopic wedge resection of the right lower lobe of the right lung and localized lymph node dissection 2 mo later.Therefore,paying attention to follow-up in LT recipients with early detection and intervention of de novo MPCs is the key to improving the survival rate and quality of life of LT recipients.CONCLUSION De novo MPCs after LT are rare,and the prognosis is poorer.However,early detection and related intervention can significantly improve the prognosis of patients.Therefore,we recommend that liver transplant recipients should be followed and screened for newly developed malignant tumors to improve the survival rate and quality of life. | Wei Rao Fu-Guo Liu Yue-Ping Jiang Man Xie | 2021 | World Journal of Clinical Cases2021，9，15： | 0 |
| 13 | Intracellular adenosine-tri-phosphate levels are lower in pediatric liver transplant recipients with infection显示文摘目的对儿童肝移植受者中CD4+T淋巴细胞内三磷酸腺苷(iATP)含量(ImmuKnow法)进行分析,并探讨其与受者临床状态的关系。方法本研究共纳入63例儿童肝移植受者,将其分为临床稳定组和感染组,分析CD4+T淋巴细胞内iATP含量与感染的关系。结果 63例患儿中,共有35例(55.6%)患儿进行了iATP的系统检测,共计120例次。其中,39例临床稳定组患儿的64例次iATP的平均值为(372±225)μg/L,且个体差异性较大。与临床稳定组患儿相比,24例感染组儿童受者的iATP更低,差异具有统计学意义(P<0.001)。系统监测显示,随着感染进展,iATP水平均值显著下降(P<0.001),且随着感染好转,其水平又有所升高(P=0.036)。另外,12例iATP水平偏低(iATP<225μg/L)的临床稳定组患儿中,并未发现活动性感染,而8例感染组患儿中,其iATP水平却偏高(iATP>225μg/L)。结论与临床稳定组的患儿相比,感染组患者的iATP水平更低,且随着感染好转,其水平逐渐升高。本研究发现,iATP水平的个体差异性较大,提示iATP水平检测可能只是反映患儿免疫状态的一个指标。iATP水平的系统监测将更有助于提示儿童肝移植受者免疫状态变化。 | Rao Wei Xie Man Sun Xiaoye Yang Tao Gao Wei Zhang Jianjun Liu Yihe Deng Yonglin Shen Zhongyang | 2014 | 实用器官移植电子杂志2014，2，4： | 0 |
| 14 | An Efficient and Green Approach to Synthesizing Enamines by Intermolecular Hydroamination of Activated Alkynes显示文摘 | ZENG Ruijie SHENG Hongting RAO Bo FENG Yan WANG Hao SUN Yehua CHEN Man ZHU Manzhou | 2015 | Chemical Research in Chinese Universities2015，31，2： | 0 |
| 15 | Safety and immunogenicity of COVID-19 vaccination among liver transplant recipients in China显示文摘To the Editor:During the ongoing coronavirus disease 2019(COVID-19)pan-demic globally,patients with chronic liver diseases(CLD),par-ticularly cirrhosis,hepatobiliary malignancies,candidates for liver transplantation(LT),and immunosuppressed LT recipients appear to be at increased risk of infections,which leads to an increase in mortality[1-6].Apart from physical distancing,quarantine and isolation,vaccination is crucial for the restraining of the epidemic and the protection from severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2)infection and aggravation of COVID-19[7,8].A recent prospective,multicenter,open-label study in China has demonstrated the safety of inactivated whole-virion SARS-CoV-2 vaccines in patients with CLD. | Qiu-Ju Tian Man Xie Ji-Tao Wang Yi Wang Bei Zhang Jin-Zhen Cai Xiao-Long Qi Wei Rao | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，6： | 0 |
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