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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath显示文摘钙绑定酷氨酸调整 phosphorylation 的蛋白质(CABYR ) 是高度多态的钙绑定 tyrosine-/threonine-phosphorylated 和 serine-/threonine-phosphorylated 涉及 capacitation 的含纤维的鞘(FS ) 蛋白质。一个通常认为的领域(氨基酸 12 鈥 ? 8 ) 对类型 II 营地依赖者蛋白质 kinase A (RII ) dimerisation 和抛锚 kinase 蛋白质(AKAP ) 的规章的子单元相应在 N 终点的蛋白质 kinase A 的有约束力的领域建议那 CABYR 可以自我装配并且绑在 AKAP。而且,有证据, CABYR 与 AKAP 限制了相互作用。然而,推进在 CABYR 之间的证据和新关系,包括 AKAP,另外的 FS 蛋白质将在理解 FS 的基本生理学是有用的。在这研究,为不可溶解的蛋白质的 co-immunoprecipitation 的新策略,以及在有集体 spectrometry 和西方的污点的联合的标准 co-immunoprecipitation 方法,被采用探索在 CABYR, AKAP3 和 Ropporin 之间的关系。结果证明 AKAP3 是有由 anti-CABYR-A polyclonal 抗体的 CABYR 的 co-immunoprecipitated,并且,相反地, CABYR 也是有由 anti-AKAP3 polyclonal 抗体的 AKAP3 的 co-immunoprecipitated。包含蛋白质的另一象 RII 一样域, Ropporin,也是有 CABYR 的 co-immunoprecipitated,显示 Ropporin 是 CABYR 的绑定之一合伙。在 CABYR, AKAP3 和 Ropporin 之间的相互作用被酵母证实二混血儿的试金。进一步的分析显示出那 CABYR 不仅由它的 RII 领域绑在 AKAP3 而且除象 RII 一样领域以外通过另外的区域绑在 Ropporin。这是 CABYR 变体形成的第一示范不仅有 scaffolding 蛋白质 AKAP3 而且与在人的精子 FS 的另一象 RII 一样包含域的蛋白质的建筑群。 | Yan-Feng Li Wei He Arabinda Mandal Young-Hwan Kim Laura Digilio Ken Klotz Charles J Flickinger John C Herr | 2011 | Asian Journal of Andrology2011，13，2： | 5 |
| 3 | Microwave-assisted extraction of total bioactive saponin fraction from Gymnema sylvestre with reference to gynmemagenin: a potential biomarker显示文摘 | MANDAL V DEWANJEE S MANDAL S C | 2009 | Phytoehem Anal2009，20，6： | 1 |
| 4 | Glutamate and cyclic AMP regulate the expression of gdactokinase in Mycobacterium smegmatis 显示文摘 | Raychaudhuri S Basu M Mandal N C | 1998 | Microbiology1998，144，8： | 1 |
| 5 | Process optimization for synthesis of CL-20显示文摘 | Mandal A K Pant C S Kasar S M | 2009 | Journal of Energetic Materials2009，27，4： | 1 |
| 6 | Xylans from Scinaia hatei: Structural features, sulfation and anti-HSV activity显示文摘 | Mandal P Pujol C A Damonte E B | 2010 | Int J Biol Macromol2010，46，： | 1 |
| 7 | Nutrient management effects on light interception, photosynthesis, growth, dry-matter production and yield of Indian mustard ( Brassica juncea) 显示文摘 | Mandal K J Sinha A C | 2004 | J Agron Crop Sci2004，190，： | 1 |
| 8 | Treatment of pterygium with corneal limbal stem cell autograft and mitomycin-a comparative study 显示文摘 | Biswas MC Shaw C Mandal R | 2007 | Indian Med Assoc2007，105，4： | 1 |
| 9 | A new relationship between the stress multipliers of Garo- falo equation for constitutive analysis of hot deform- ation in modified 9Cr-lMo (P91) steel显示文摘 | Phaniraj C Samantaray D Mandal S | 2011 | Mater Sci Eng A2011，528，18： | 1 |
| 10 | Regulation of matrix metalloprot einases, an overview显示文摘 | C hakraborti S Mandal M Das | 2003 | Mol Cell Biochem2003，253，12： | 1 |
| 11 | Genetic diversity analysis of Sclerotinia sclerotiorum causing stem rot in chickpea using RAPD, ITS- RFLP, ITS sequencing and mycelial compatibility grouping显示文摘 | Mandal A K Dubey S C | 2012 | World J Microbiol Biotechnol2012，28，4： | 1 |
| 12 | Development of a landquality index for Sorghumin In Dian Semiaridtropics (SAT) 显示文摘 | Mandal D K Mandal C Velayutham M | 2001 | Agricultual Systems2001，70，： | 1 |
| 13 | Current practice in surveillance strategy for patients with Barrett's esophagus in the UK显示文摘 | Mandal A Playford R J Wieks A C | 2003 | Aliment Pharmacol Ther2003，17，10： | 1 |
| 14 | Anti-inflammatory action ofSwertia chirata 显示文摘 | Mandal S Dos P C Joshi P C | 1992 | Fitoterapia1992，63，2： | 1 |
| 15 | Short Jute Fiber-Reinforced Polypropylene Composites:Compatibilizer显示文摘 | Rana A K Mandal A Mitra B C | 1998 | Journal of Applied Polymer Science1998，69，2： | 1 |
| 16 | Complexity of fragmentable object bin packing and an application显示文摘 | Mandal C A Chakrabarti P P Ghose S | 1998 | Computers and Mathematics with Applications1998，35，11： | 1 |
| 17 | Evolution of microstructure in spray formed Al-18%Si alloy显示文摘 | SRIVASTAVA V C MANDAL R K OJHA S N | 2004 | Materials Science and Engineering2004，383，1： | 1 |
| 18 | Experimental and CFD estimation of heat transfer in helically coiled heat exchangers显示文摘 | JAYAKUMAR J S MAHAJANI S M MANDAL J C | | 0，，： | 1 |
| 19 | Numerical modeling of heterogeneous flow fields around rigid objects with special reference to particle paths,strain shadows and foliation drag显示文摘 | Mandal N Samanta S K Chakraborty C | 2001 | Tectonophysics2001，330，： | 1 |
| 20 | Experimental amt CFD estimation of heat transhr in helieally coiled heat exchangers 显示文摘 | Jayakumar J S Mahajani S M Mandal J C el al | 2008 | Chemical Engineering Research and Design2008，86，3： | 1 |
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