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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 3 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Modeling of resin transfer molding of composite materials with oriented unidirectional plies显示文摘 | CAIRNS D S HUMBERT D R MANDELL J F | 1999 | Composites Part A:Applied Science and Manufacturing1999，30，3： | 1 |
| 5 | Autism显示文摘 | Susan E Levy David S Mandell Robert T Schultz | 2009 | The Lancet2009，，9701： | 1 |
| 6 | An error analysis of failure prediction techniques derived from fracture mechanics 显示文摘 | Wiederhom S M Fuller E R Mandel J | 1976 | Journal of the American Ceramic Society1976，59，910： | 1 |
| 7 | Measurement of saccharifying cellulase显示文摘 | MANDEL S M | 1976 | Biotechnol Bioeng1976，6，： | 1 |
| 8 | Effects of carcass weight class and postmortem aging on carcass characteristics and sensory at- tributes in grain-fed veal显示文摘 | Mandell I B Maclaurin T Buttenhan S | 2001 | Food Sci2001，66，5： | 1 |
| 9 | Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice:effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate显示文摘 | Mandel S Maor G Youdim MB | | 0，，： | 1 |
| 10 | The rele- vance of iron in the pathogenesis of Parkinson's disease显示文摘 | Sian-Htilsmann J Mandel S Youdim MB | 2011 | J Neurochem2011，118，6： | 1 |
| 11 | Radioactive iodine and the salivary glands显示文摘 | Mandel S J Mandel L | 2003 | Thyroid2003，13，3： | 1 |
| 12 | Certain special features of the formation of welds made at high speeds显示文摘 | PATON E O MANDEL' BERG S L Sidorenko B G | 1971 | Autom Weld1971，24，8： | 1 |
| 13 | The role of intraoperative rapid parathyroid hormone monitoring for predicting thyroidectomy-related hypocalcemia显示文摘 | Higgins KM Mandell DL Govindaraj S | 2004 | Arch Otolaryngol Head Neck Surg2004，130，1： | 1 |
| 14 | Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate:implications for neurodegenerative diseases显示文摘 | Mandel S Weinreb O Amit T Youdim MB | | 0，，： | 1 |
| 15 | Designing marketplaces of the artificial with consumers in mind: Four ap proaches to understanding consumer behavior in electronic environments显示文摘 | Bellman S Johnson E Lohse G and Mandel N | 2006 | Journal of Interactive Marketing2006，20，1： | 1 |
| 16 | Enzymatic hydrolysis of cellulose: Evaluation of cellulose culture filtrates under use condition 显示文摘 | MANDEL S M | 1981 | Biotechnol Bioeng1981，23，： | 1 |
| 17 | Neuroprotective strategies in Parkinson's disease: an update on progress显示文摘 | Mandel S Grunblatt E Riederer P | 2003 | CNS Drugs2003，17，10： | 1 |
| 18 | Multigrid Methods for Nearly Singular Linear Equations and Eigenvalue Problems显示文摘 | CAI Z MANDEL J MCCORMICK S | 1997 | SIAM1997，34，： | 1 |
| 19 | A decade of experience using roTor inhibitors in liver transplanta- tion显示文摘 | Campsen J Zimmerman MA Mandell S | 2011 | J Transplant2011，2011，91： | 1 |
| 20 | Conversion of perianth into reproductive organs by ectopic expression of tobacco floral homeotic gene NAGI显示文摘 | KEMPIN S A MANDEL M A YANSOSKY M F | 1993 | Plant Physion1993，103，： | 1 |
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