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| 1 | Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial显示文摘 | Vincent Wai-Sun Wong Ruth Suk-Mei Chan Grace Lai-Hung Wong Bernice Ho-Ki Cheung Winnie Chiu-Wing Chu David Ka-Wai Yeung Angel Mei-Ling Chim Jennifer Wing-Yan Lai Liz Sin Li Mandy Man-Mei Sea Francis Ka-Leung Chan Joseph Jao-Yiu Sung Jean Woo Henry Lik-Yue | 2013 | Journal of Hepatology2013，，3： | 2 |
| 2 | Varioxepine A, a 3H- oxepine-containing Alkaloid with a new oxa-cage from the marine algal-derived endophytic fungus Paecilomyces variotii 显示文摘 | Zhang P Mandi A Li XM et 01 | 2014 | Org Lett2014，16，18： | 1 |
| 3 | N-N-coupled indolo-ses- quiterpene atropo-diastereomers from a marine-derived acti- nomycete显示文摘 | Zhang Q Mandi A Li S | 2012 | European J Org Chem2012，，27： | 1 |
| 4 | The Caenorhabditis elegans hunchback -like Gene lin-57/hbl-1 Controls Developmental Time and Is Regulated by MicroRNAs显示文摘 | Juan E. Abrahante Aric L. Daul Ming Li Mandy L. Volk Jason M. Tennessen Eric A. Miller Ann E. Rougvie | 2003 | Developmental Cell2003，，5： | 1 |
| 5 | Proteasome Involvement in the Repair of DNA Double-Strand Breaks显示文摘 | Nevan J. Krogan Mandy H.Y. Lam Jeffrey Fillingham Michael-Christopher Keogh Marinella Gebbia Joyce Li Nira Datta Gerard Cagney Stephen Buratowski Andrew Emili Jack F. Greenblatt | 2004 | Molecular Cell2004，，： | 1 |
| 6 | Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial<!-- Doctopic: GMD -->显示文摘 | Vincent Wai-Sun Wong Ruth Suk-Mei Chan Grace Lai-Hung Wong Bernice Ho-Ki Cheung Winnie Chiu-Wing Chu David Ka-Wai Yeung Angel Mei-Ling Chim Jennifer Wing-Yan Lai Liz Sin Li Mandy Man-Mei Sea Francis Ka-Leung Chan Joseph Jao-Yiu Sung Jean Woo Henry Lik-Yue | 2013 | Journal of Hepatology2013，，： | 1 |
| 7 | Experimental and Computational Analysis of the Solution and Solid-State Conformations of Hexadepsipeptides from Beauveria felina显示文摘Chemical investigation of Beouverio felina,a marine-derived entomopathogenic fungus,obtained two new destruxin hexadepsipeptides(1 and 2)containing an/.-Ala^(5)residue instead of the usual A/-Me-L-Ala^(5).Interestingly,the presence of the/.-Ala^(5)residue enabled two slowly-exchanging solution conformers with cis/trons(ILE^(3))-(A/-Me-Val^(4))amide bond for 1 and 2 with 1.5:1 and 1:1 cis/trans ratios,respectively,while only the conformer with c/s amide bond was found in the solid-state.The solution and solid-state conformers were studied by NMR,X-ray diffraction and solution and solid-state ECD measurements,as well as by TDDFT-ECD calculations.Structural(conformational)parameter-activity correlations suggested that the extended destruxin geometry with the preferred c/s(ILE^(3))-(A/-Me-Val^(4))bond probably resulted in improved bioactivity and reduced toxicity for the destruxin class.This was the first report on the interconversion phenomenon of cis/trans amide bonds of destruxin class,which could give insights in the development of bioactive destruxin agents with lower toxicity. | Feng-Yu Du Attila Mandi Xiao-Ming Li Ling-Hong Meng Tibor Kurtan Bin-Gui Wang | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 8 | Modelling and Dynamic Characteristics for a Non-metal Pressurized Reservoir with Variable Volume显示文摘With the increasing demand to reduce emissions and save energy,hydraulic reservoirs require new architecture to optimize their weight,space,and volume.Conventional open reservoirs are large,heavy,and easily polluted,and threaten the operation of hydraulic systems.A closed reservoir provides the advantages of small volume and light weight,compared to open reservoirs.In this study,a non-metallic pressure reservoir with variable volume is designed and manufactured for closed-circuit hydraulic systems.The reservoir housing is made of rubber,and the Mooney-Rivlin model is chosen based on the rubber strain properties.The FEA simulation for the reservoir is performed using ANSYS Workbench to obtain the structural stiffness.The major contribution is the establishment of mathematical models for this reservoir,including the volume equation changing with height,flow equation,and force balance equation,to explore the output characteristics of this reservoir.Based on these results,simulation models were built to analyze the output characteristics of the reservoir.Moreover,the test rig of a conventional hydraulic system was transformed into a closed-circuit asymmetric hydraulic system for the reservoir,and preliminary verification experiments were conducted on it.The results demonstrate that the designed reservoir can absorb and discharge oil and supercharge pump inlet to benefit system operation.The changes in the volume and pressure with displacements under different volume ratios and frequencies were obtained,which verified the accuracy of the mathematical models.Owing to its lightweight design and small volume,the reservoir can replace conventional open reservoirs,and this lays a foundation for future theoretical research on this reservoir. | Pei Wang Jing Yao Baidong Feng Mandi Li Dingyu Wang | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 0 |
| 9 | Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation显示文摘The medicinal mushroom Ganoderma lucidum(GL,Reishi or Lingzhi)exhibits an inhibitory effect on cancers.However,the underlying mechanism of the antitumor activity of GL is not fully understood.In this study,we characterized the gene networks regulated by a commercial product of GL containing a mixture of spores and fruiting bodies namely“GLSF”,in colorectal carcinoma.We found that in vitro co-administration of GLSF extract at non-toxic concentrations significantly potentiated growth inhibition and apoptosis induced by paclitaxel in CT26 and HCT-15 cells.GLSF inhibited NF-κB promoter activity in HEK-293 cells but did not affect the function of P-glycoprotein in K562/DOX cells.Furthermore,we found that when mice were fed a modified diet containing GLSF for 1 month prior to the CT26 tumor cell inoculation,GLSF alone or combined with Nab-paclitaxel markedly suppressed tumor growth and induced apoptosis.RNA-seq analysis of tumor tissues derived from GLSF-treated mice identified 53 differentially expressed genes compared to normal tissues.Many of the GLSFdown-regulated geneswere involved in NF-κB-regulated inflammation pathways,such as IL-1β,IL-11 and Cox-2.Pathway enrichment analysis suggested that several inflammatory pathways involving leukocytemigration and adhesion were most affected by the treatment.Upstream analysis predicted activation of multiple tumor suppressors such asα-catenin and TP53 and inhibition of critical inflammatory mediators.“Cancer”was the major significantly inhibited biological effect of GLSF treatment.These results demonstrate that GLSF can improve the therapeutic outcome for colorectal cancer through a mechanism involving suppression of NF-κB-regulated inflammation and carcinogenesis. | Mandy M.Liu Tiantian Liu Steven Yeung Zhijun Wang Bradley Andresen Cyrus Parsa Robert Orlando Bingsen Zhou Wei Wu Xia Li Yilong Zhang Charles Wang Ying Huang | 2021 | Precision Clinical Medicine2021，4，4： | 0 |
| 10 | 人乳头瘤病毒衣壳蛋白C末端结构臂具有免疫原性并参与病毒-宿主细胞的相互作用显示文摘宫颈癌是全球女性第二大常见恶性肿瘤,人乳头瘤病毒(HPV)是导致女性宫颈癌发生的主要原因。HPV型别众多,主要的高危型型别种类多达15种,且型别间免疫血清交叉保护能力极低,目前国际上已上市的预防性多价HPV疫苗均不能为接种者提供完全保护。 | Zhihai Li Xiaodong Yan Hai Yu Daning Wang Shuo Song Yunbing Li Maozhou He Qiyang Hong Qingbing Zheng Qinjian Zhao Ying Gu Jun Zhang Mandy E.W.Janssen Giovanni Cardone Norman H.Olson Timothy S.Baker 李少伟 Ningshao Xia | 2017 | 科学新闻2017，19，4： | 0 |
| 11 | Investigation of Movement and Deposition Behaviors of Solid Particles in Hydraulic Water Reservoir via the CFD‑DEM Coupling Method显示文摘Solid contamination existing as solid particles in power fluid transmission systems may lead to transmission performance reduction,system failures,and component damage.The hydraulic reservoir will deposit the contamination and store hydraulic fluid.To investigate its purification ability for solid contamination,experiments and simulations for the motion and deposition status of the typical hydraulic system particles are carried out to reveal the interaction of particles and fluid in hydraulic water reservoirs.The results show that the CFD-DEM coupling method could predict the accurate deposition position of iron particles and sand particles when ignoring the small-scale turbulence effect in the flow field.Besides,the particle motion traces and deposition patterns in the reservoir illustrate that the flow development on the bottom surface results in the particles turning,and particles tend to settle in the low flow energy position.The motion of particles is also linked to particles Stokes number,and the same-size sand particles are easily driven by the fluid.The contribution of this paper could provide a guide for predicting the particle motion and deposition pattern in the hydraulic reservoir. | Mandi Li Decai Kong Qi Guo Xiangyu Liu Jing Yao Jianjun Hu Lijuan Chen | 2022 | Chinese Journal of Mechanical Engineering2022，35，6： | 0 |
| 12 | 怪咖青年的圣诞礼物显示文摘一转眼,又近圣诞大节之期。自古只要是过节。就得搞气氛。于是乎,有圣诞老人,有圣诞树,有圣诞礼物,还有家庭团圆,那是一样都不能少。所以2012年圣诞节来临之际,最应景的,自然还是喜剧美剧中的圣诞集,它们多半都会给你我一个惊喜。这期,我们一起来回顾风靡整个高校的《生活大爆炸》之圣诞篇,看看里面的科学天才加怪异青年都是如何处理圣诞礼物! | Mandy Li | 2012 | 英语沙龙(高中)2012，，12： | 0 |
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