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| 1 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 2 | Hypoxia-inducible factor-1 ( HIF-113 )is upregulated in a HIF-1 t-dependent manner in 518A2 human melanoma cells under hypoxic conditions显示文摘 | Mandl M KapeUer B Lieber R | 2013 | Biochem Biophys Res Commun2013，434，1： | 1 |
| 3 | High glucose increases prostaglandin E2 synthesis in human peritoneal mesothelial cells: role of hyperosmolarity显示文摘 | Sitter T Haslinger B Mandl S | 1997 | Kindey Int1997，51，1： | 1 |
| 4 | Absorption of carbon dioxide into aqueous blends of 2 amino-2-methyl-1-propanol and mono - ethanolamine显示文摘 | Mandl B P Bandyopadhyay S S | 2006 | Chemical Engineering Science2006，61，16： | 1 |
| 5 | Measuring Outbreak-Detection Performance By Using Controlled Feature Set Simulations 显示文摘 | Kenneth D Mandl B Reis C | 2004 | MMWR2004，，： | 1 |
| 6 | HealthMap: global infectious disease monitoring through automated classifica- tion and visualization of internet media reports显示文摘 | Freifeld C C Mandl K D Reis B Y | 2008 | Journal of the American Medical Informatics Association2008，，15： | 1 |
| 7 | Endoplasmic reticulum: nutrient sensor in physiology and pathology显示文摘 | József Mandl Tamás Mészáros Gábor Bánhegyi László Hunyady Miklós Csala | 2009 | Trends in Endocrinology & Metabolism2009，，4： | 1 |
| 8 | Stress on redox显示文摘 | Gábor Bánhegyi Angelo Benedetti Miklós Csala József Mandl | 2007 | FEBS Letters2007，，19： | 1 |
| 9 | Effect of high glucose concentration on the synthesis of monocyte chemoattractant protein - 1 in human peritoneal mesothelial cells: involvement of protein kinase C 显示文摘 | Haslinger B Mandl - Weber S Sellmayer A | 2001 | Nephron2001，87，4： | 1 |
| 10 | Orientation dependent sputter yield of aluminum 显示文摘 | Manova D Schreck M Mandl S Stritzker B Rauschenbach B | 2002 | Surface and Coatings Technology2002，7275，： | 1 |
| 11 | Hypoxia-inducible factor-1β(HIF-1β)is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions显示文摘 | MANDL M KAPELLER B LIEBER R | 2013 | Biochem Biophys Res Commun2013，434，1： | 1 |
| 12 | Time series modeling for syndromic surveillance显示文摘 | REIS B Y MANDL K D | 2003 | BMC Med Infor and Decision MaKing2003，3，： | 1 |
| 13 | High temperature plasma immersion ion implantation into Molybdenum显示文摘 | Mariova D Mandl S Rauschenbach B | 2004 | Surface and Coatings Technology2004，181，： | 1 |
| 14 | Reservoir host immune responses to emerging Zoonotic viruses 显示文摘 | Mandl J N Ahmed R Barreiro L B | 2015 | Cell2015，160，12： | 1 |
| 15 | HealthMap: global infectious disease monitoring through automated classifica- tion and visualization of internet media reports显示文摘 | Freifeld C C Mandl K D Reis B Y | 2008 | Journal of the American Medical Informaties Association2008，15，2： | 1 |
| 16 | Measuring Outbreak - Detection Performance By Using Controlled Feature Set Simulations 显示文摘 | Kenneth D Mandl B Reis C | 2004 | MMWR2004，，： | 1 |
| 17 | Concentration dependent nitrogen diffusion coefficient in expanded austenite formed by ion implantation显示文摘 | MANDL S RAUSCHENBACH B | 2002 | Journal of Applied Physics2002，91，： | 1 |
| 18 | Textured titanium oxide thin films produced by vacuum arc deposition显示文摘 | Mandl S Thorwarth G Rauschenbach B | 2000 | Surface and Coatings Technology2000，134，： | 1 |
| 19 | RNA: the new revolution in nucleic acid vaccines显示文摘 | Geall A J Mandl C W Ulmer J B | 2013 | Semin Immunol2013，25，2： | 1 |
| 20 | Anisotropic strain in nitrided austenitic stainless steel 显示文摘 | Rauschenbach B | 2000 | Journal of Applied Physics2000，88，： | 1 |
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